The Association of Oxidative and Antioxidant Potential with Cardiometabolic Risk Profile in the Group of 60- to 65-Year-Old Seniors from Central Poland

Abstract

Pathogenesis of cardiovascular diseases is caused by, inter alia, oxidative stress. On the other hand, cardiovascular risk factors may cause redox imbalance. The pathological pathways between those components are to be determined. In the group comprised of 300 sex-matched subjects, we evaluated a number of cardiovascular risk factors: blood pressure, body mass, lipids, glucose, homocysteine, uric acid, von Willebrand factor (vWF), VCAM-1 and ICAM-1. The presence of cardiovascular diseases and drugs for their treatment were examined. Secondly, we assessed total antioxidative status (TAS), total oxidative status (TOS) and other markers of oxidative stress. TAS was inversely related to LDL cholesterol. TOS was positively associated with BMI and female sex, but negatively associated with the use of angiotensin II receptor antagonists. Plasma lipid peroxides concentration was positively related to ICAM-1 and presence of stroke, whereas platelet lipid peroxides were positively associated with vWF. Platelets proteins thiol groups were in a positive relationship with vWF, but in a negative relationship with uric acid and diagnosed lipid disorders. Both free thiol and amino groups were positively associated with plasma glucose. Platelets free amino groups were related to platelets count. Superoxide generation by blood platelets (both with and without homocysteine) was positively connected to glucose level. Among women, oxidative markers appear to be more related to glucose level, whereas among men they are related to body mass indices. TAS, TOS and oxidative markers are largely related to modifiable cardiovascular risk factors such as body mass, and intake of drugs such as angiotensin II receptor blockers. Plasma and platelet oxidation markers appear to be especially associated with glucose concentration. The presented analyses unanimously indicate strong connections between cardiovascular risk factors and redox potential and specify how cardiometabolic interventions may counter-balance oxidative stress.

Contribution of Physical Activity to the Oxidative and Antioxidant Potential in 60–65-Year-Old Seniors

“…The inclusion criteria were age within the range of 60 to 65 years and the consent to participate in the study. The study was approved by the Committee on the Ethics of Research in Human Experimentation at the Medical University of Lodz (RNN/648/14/KB dated 23 September 2014), and was performed according to the guidelines of the Helsinki Declaration for human research [ 33 , 34 ].…”

“…In previous studies, we have reported the complex associations between oxidative/antioxidative potential and cardiometabolic risk profile, as well as between PA and cardiovascular risk factors in the population of 60–65-year-old subjects [ 33 , 34 ]. In this study, we estimate how the PA (assessed both through the profile of health behaviors and overall energy expenditure) may relate to the TAS, TOS and the variety of plasma and platelets markers of an oxidation in the population of younger seniors.…”

The Moderating Effect of Physical Activity on the Relationship Between Neutrophils and Depression: A Cross-sectional Analysis Based on the NHANES Database

“…Furthermore, studies have con rmed that appropriate PA has anti-in ammatory effects [19] . It can not only reduce the circulating count of white blood cells [20] but also enhance antioxidant capacity, mitigating oxidative stress [21][22] , thereby reducing the risk factor for depression.…”

Oxidative Stress in Cardiovascular Disease and Comorbidities

“…In a population study, Sołtysik and collaborators [ 8 ] investigate the circulating oxidant and antioxidant potential and its association with the cardiometabolic risk in ageing patients. The authors assess multiple cardiovascular risk factors as well as the total antioxidative status (TAS) and total oxidative status (TOS), identifying that TAS and TOS are largely related to modifiable cardiovascular risk factors such as body mass and are affected by drugs such as angiotensin II receptor blockers.…”