The association of polymorphisms in BMP2/MYO1H and skeletal Class II div.1 maxillary and mandibular dimensions. A preliminary ‘report

Hussein, Ali S.; Porntaveetus, .Thantrira; Abid, .Mushriq

doi:10.1016/j.sjbs.2022.103405

Cited by 2 publications

(2 citation statements)

References 48 publications

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“…What do exist are studies showing that SNPs in genes involved in the aforesaid molecular processes are related to mandibular size and position phenotypes ( i.e. , jaw sagittal and vertical relationships, mandibular retrognathism, mandibular length) 18 – 20 . Considering that condylar dimensions could influence mandibular traits 21 , 22 , it is reasonable to hypothesize that SNPs in endochondral development-related genes might primarily affect the configuration of the mandibular condyle.…”

Section: Introductionmentioning

confidence: 99%

BMP2 rs1005464 is associated with mandibular condyle size variation

Marañón-Vásquez,

de Souza Araújo,

de Oliveira Ruellas

et al. 2024

Sci Rep

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This study aimed to evaluate the association between single nucleotide polymorphisms (SNPs) in endochondral development-related genes and mandibular condyle shape, size, volume, and symmetry traits. Cone-beam Computed Tomographies and genomic DNA from 118 individuals were evaluated (age range: 15–66 years). Data from twelve 3D landmarks on mandibular condyles were submitted to morphometric analyses including Procrustes fit, principal component analysis, and estimation of centroid sizes and fluctuating asymmetry scores. Condylar volumes were additionally measured. Seven SNPs across BMP2, BMP4, RUNX2 and SMAD6 were genotyped. Linear models were fit to evaluate the effect of the SNPs on the mandibular condyles’ quantitative traits. Only the association between BMP2 rs1005464 and centroid size remained significant after adjusting to account for the false discovery rate due to multiple testing. Individuals carrying at least one A allele for this SNP showed larger condylar size than common homozygotes GG (β = 0.043; 95% CI: 0.014—0.071; P value = 0.028). The model including BMP2 rs1005464, age and sex of the participants explained 17% of the variation in condylar size. Shape, volume, and symmetry were not associated with the evaluated SNPs. These results suggest that BMP2 rs1005464 might be associated with variation in the mandibular condyles size.

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Section: Introductionmentioning

confidence: 99%

BMP2 rs1005464 is associated with mandibular condyle size variation

Marañón-Vásquez,

de Souza Araújo,

de Oliveira Ruellas

et al. 2024

Sci Rep

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“…Skeletal Class III malocclusion has a substantial hereditary component phenotypic, which has long been recognized (8) . Hereditary variables are implicated in the development of skeletal malocclusions, according to twin and family genetic investigations (9) . By reviewing a person's full genome or doing a candidate gene study, one may compare phenotypes versus genetics.…”

Section: Introductionmentioning

confidence: 99%

Gene polymorphisms for patients with Class III malocclusion. A pilot study

Bahya,

Abid,

Alsahafi

2024

J Bagh Coll Dent

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Background: The interactions of genetic and environmental factors may account for the variability in the expression of malocclusion. The study of malocclusion etiology is fundamental to understand the biology underlying craniofacial growth and dental relations. Understanding biology will improve progress toward effective treatment and prevention, thereby decreasing the burden of this condition. Aims: The present study was set out to investigate the association of the single nucleotide polymorphisms (SNPs) in different genes (rs2249492 in COLA1A, rs4434184 in SOX2, rs2162540 in FGFR2, rs11696257 in MAFB, and rs881301 in FGFR1) with Class III malocclusion. Materials and Methods: A total of 10 patients, comprising 5 with Skeletal Class I and 5 with Skeletal Class III malocclusion, were included in the present study. Salivary DNA samples were collected and analyzed using Sanger sequencing. Digital tracing was performed on lateral cephalometric radiographs by using AutoCAD software for digitization to assess the anterio-posterior and vertical relationship of the maxillary and mandibular arch. Results: Out of five genes polymorphisms only two genes polymorphisms (SOX2 and FGFR1) showed an association with Cl.III malocclusion. Conclusion: This study reveals that SOX2 and FGFR1 genetic polymorphisms may be responsible for Class III malocclusion. However, more study with a larger participant pool is required to confirm these findings.

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The association of polymorphisms in BMP2/MYO1H and skeletal Class II div.1 maxillary and mandibular dimensions. A preliminary ‘report

Cited by 2 publications

References 48 publications

BMP2 rs1005464 is associated with mandibular condyle size variation

BMP2 rs1005464 is associated with mandibular condyle size variation

Gene polymorphisms for patients with Class III malocclusion. A pilot study

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