The Association of Thyroid Hormones with Coronary Atherosclerotic Severity in Euthyroid Patients

Abstract

The aim of the work was to explore the correlation between thyroid hormones and coronary atherosclerotic severity. This cross-sectional study included 340 euthyroid patients who underwent diagnostic coronary artery angiography (CAG). Gensini Score (GS) was applied to assess the severity of coronary atherosclerosis. Thyroid hormones and routine biochemical parameters were measured. The associations between thyroid hormones and coronary atherosclerosis severity were analyzed. Thyroid hormones levels or parameters were taken as both continuous variables and tertiles into analysis, and the lowest tertile was usually used as the reference (OR=1) for medium and highest tertiles. Free triiodothyronine (FT3) level was associated with GS≥22 (Median GS) in Model I adjusted for age and sex [Continuous: OR=0.46, 95% CI (0.23, 0.92), p=0.029; Tertile 3: OR=0.54, 95% CI (0.30, 0.97), p=0.038], and Model II adjusted for all known risk factors of coronary artery disease (CAD) [Continuous: OR=0.44, 95% CI (0.20, 0.95), p=0.036; Tertile 3: OR=0.49, 95% CI (0.25, 0.96), p=0.039]. Subjects with highest tertile of FT3 to free thyroxine (FT4) ratio (FT3/FT4 ratio) appeared to have the remarkably decreased risk of CAD in both Non-adjusted Model [OR=0.49, 95% CI (0.24, 0.98), p=0.044] and Model I [OR=0.45, 95% CI (0.22, 0.93), p=0.031]. Higher FT3 level within normal range was independently and negatively associated with severity of coronary atherosclerosis. Besides, FT3/FT4 ratio was remarkably correlated with the prevalence of CAD in euthyroid population.

Impaired sensitivity to thyroid hormones and carotid plaque in patients with coronary heart disease: A RCSCD-TCM study in China

“…Interestingly, our study also found that when used as a reference in the Q1 group, peripheral thyroid hormone sensitivity index FT3/FT4 was negatively associated with carotid plaque in the Q4 group, and the sensitivity was the strongest in the Q4 group. As many studies confirmed the positive effects of elevated FT3/FT4 on cardiovascular risk and arterial stiffness markers (39)(40)(41). However, studies have reported conflicting views.…”

Association between sensitivity to thyroid hormone indices and the risk of osteoarthritis: an NHANES study

“…Its biologic function is considered to be related to the inhibition of bone matrix mineralization [35,36]. In addition, multiple cross-sectional studies have found that FT3/FT4, TSHI, and TT4RI are significantly correlated with chronic kidney disease (CKD), non-alcoholic fatty liver disease (NAFLD), and coronary artery disease (CAD) [37][38][39]. As described in this article, we found that FT3/FT4 levels decreased with increasing risk of OA, whereas TSHI and TT4RI levels increased with increasing OA prevalence in the subjects.…”

Association Between Sensitivity to Thyroid Hormone Indices and Diabetic Retinopathy in Euthyroid Patients with Type 2 Diabetes Mellitus

“…19 These new comprehensive indicators can systematically reflect the regulation of TH homeostasis. They may be less biased than single indicators with a better explanation for the various associations between TH changes and the risk of DR. TSHI and TT4RI are significantly linked to the prevalence of coronary heart disease (CAD), 27 NAFLD, 28 and chronic kidney disease. 29 A strong link was discovered between TFQI and obesity, metabolic syndrome, and diabetes-related mortality.…”