The associations between multisensory temporal processing and symptoms of schizophrenia

Stevenson, Ryan A.; Park, Sohee; Cochran, Channing; McIntosh, Lindsey Gilling; Noel, Jean‐Paul; Barense, Morgan D.; Ferber, Susanne; Wallace, Mark T.

doi:10.1016/j.schres.2016.09.035

Cited by 126 publications

(97 citation statements)

References 47 publications

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“…The CognitivePerceptual component concerns the disposition to unusual perceptual experiences, such as hallucinations, which are associated with impaired multisensory integration and TBW in patients. 7,79 Hence, we specifically focused on this subscale in our analysis. While its distribution was slightly positively skewed, its skewness and kurtosis were within the acceptable range (skewness < 1, kurtosis < 2.5).…”

Section: Schizotypal Personality Questionnairementioning

confidence: 99%

A Neural “Tuning Curve” for Multisensory Experience and Cognitive-Perceptual Schizotypy

Ferri

Nikolova

Perrucci

et al. 2017

Schizophrenia Bulletin

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Our coherent perception of external events is enabled by the integration of inputs from different senses occurring within a range of temporal offsets known as the temporal binding window (TBW), which varies from person to person. A relatively wide TBW may increase the likelihood that stimuli originating from different environmental events are erroneously integrated and abnormally large TBW has been found in psychiatric disorders characterized by unusual perceptual experiences. Despite strong evidence of inter-individual differences in TBW, both within clinical and nonclinical populations, the neurobiological underpinnings of this variability remain unclear. We adopted an integrated strategy linking TBW to temporal dynamics in functional magnetic resonance imaging (fMRI)-resting-state activity and cortical excitation/inhibition (E/I) balance. E/I balance was indexed by glutamate/Gamma-AminoButyric Acid (GABA) concentrations and common variation in glutamate and GABA genes in a healthy sample. Stronger resting-state longrange temporal correlations, indicated by larger power law exponent (PLE), in the auditory cortex, robustly predicted narrower audio-tactile TBW, which was in turn associated with lower cognitive-perceptual schizotypy. Furthermore, PLE was highest and TBW narrowest for individuals with intermediate levels of E/I balance, with shifts towards either extreme resulting in reduced multisensory temporal precision and increased schizotypy, effectively forming a neural "tuning curve" for multisensory experience and schizophrenia risk. Our findings shed light on the neurobiological underpinnings of multisensory integration and its potentially clinically relevant inter-individual variability.

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Section: Schizotypal Personality Questionnairementioning

confidence: 99%

A Neural “Tuning Curve” for Multisensory Experience and Cognitive-Perceptual Schizotypy

Ferri

Nikolova

Perrucci

et al. 2017

Schizophrenia Bulletin

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“…In addition to findings of unisensory processing deficits, there is also some evidence for aberrant multisensory processing in SCZ (Foucher et al, 2007; Stekelenburg et al, 2013; Roa Romero et al, 2016a,b; Stevenson et al, 2016; for a review see Tseng et al, 2015). One study examined simultaneity judgments in unisensory and multisensory stimuli and found that SCZ have a lengthened window of simultaneity for unisensory visual, unisensory auditory, and bisensory audiovisual stimuli (Foucher et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Beta/Gamma Oscillations and Event-Related Potentials Indicate Aberrant Multisensory Processing in Schizophrenia

et al. 2016

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Recent behavioral and neuroimaging studies have suggested multisensory processing deficits in patients with schizophrenia (SCZ). Thus far, the neural mechanisms underlying these deficits are not well understood. Previous studies with unisensory stimulation have shown altered neural oscillations in SCZ. As such, altered oscillations could contribute to aberrant multisensory processing in this patient group. To test this assumption, we conducted an electroencephalography (EEG) study in 15 SCZ and 15 control participants in whom we examined neural oscillations and event-related potentials (ERPs) in the sound-induced flash illusion (SIFI). In the SIFI multiple auditory stimuli that are presented alongside a single visual stimulus can induce the illusory percept of multiple visual stimuli. In SCZ and control participants we compared ERPs and neural oscillations between trials that induced an illusion and trials that did not induce an illusion. On the behavioral level, SCZ (55.7%) and control participants (55.4%) did not significantly differ in illusion rates. The analysis of ERPs revealed diminished amplitudes and altered multisensory processing in SCZ compared to controls around 135 ms after stimulus onset. Moreover, the analysis of neural oscillations revealed altered 25–35 Hz power after 100 to 150 ms over occipital scalp for SCZ compared to controls. Our findings extend previous observations of aberrant neural oscillations in unisensory perception paradigms. They suggest that altered ERPs and altered occipital beta/gamma band power reflect aberrant multisensory processing in SCZ.

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“…One possible way this could be done is through dynamically changing the timing over which stimuli are bound and integrated (i.e., an alteration in the size of temporal-binding windows, TBW; Stevenson et al 2016; Noel et al 2015a, 2016a, b, 2017a, b; De Niear et al 2017). Alternatively, compensation for the changing spatiotemporal characteristics of the stimuli may be accomplished by shifting the temporal asynchrony that is considered most synchronous (i.e., an alteration in the point of subjective simultaneity, PSS).…”

Section: Introductionmentioning

confidence: 99%

Audiovisual integration in depth: multisensory binding and gain as a function of distance

et al. 2018

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The integration of information across sensory modalities is dependent on the spatiotemporal characteristics of the stimuli that are paired. Despite large variation in the distance over which events occur in our environment, relatively little is known regarding how stimulus-observer distance affects multisensory integration. Prior work has suggested that exteroceptive stimuli are integrated over larger temporal intervals in near relative to far space, and that larger multisensory facilitations are evident in far relative to near space. Here, we sought to examine the interrelationship between these previously established distance-related features of multisensory processing. Participants performed an audiovisual simultaneity judgment and redundant target task in near and far space, while audiovisual stimuli were presented at a range of temporal delays (i.e., stimulus onset asynchronies). In line with the previous findings, temporal acuity was poorer in near relative to far space. Furthermore, reaction time to asynchronously presented audiovisual targets suggested a temporal window for fast detection—a range of stimuli asynchronies that was also larger in near as compared to far space. However, the range of reaction times over which multisensory response enhancement was observed was limited to a restricted range of relatively small (i.e., 150 ms) asynchronies, and did not differ significantly between near and far space. Furthermore, for synchronous presentations, these distance-related (i.e., near vs. far) modulations in temporal acuity and multisensory gain correlated negatively at an individual subject level. Thus, the findings support the conclusion that multisensory temporal binding and gain are asymmetrically modulated as a function of distance from the observer, and specifies that this relationship is specific for temporally synchronous audiovisual stimulus presentations.Electronic supplementary materialThe online version of this article (10.1007/s00221-018-5274-7) contains supplementary material, which is available to authorized users.

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The associations between multisensory temporal processing and symptoms of schizophrenia

Cited by 126 publications

References 47 publications

A Neural “Tuning Curve” for Multisensory Experience and Cognitive-Perceptual Schizotypy

A Neural “Tuning Curve” for Multisensory Experience and Cognitive-Perceptual Schizotypy

Beta/Gamma Oscillations and Event-Related Potentials Indicate Aberrant Multisensory Processing in Schizophrenia

Audiovisual integration in depth: multisensory binding and gain as a function of distance

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