The associations between serum 25-hydroxyvitamin D level and the risk of total fracture and hip fracture

Feng, Yu; Cheng, Guangqi; Wang, H.; Chen, B.

doi:10.1007/s00198-017-3955-x

Cited by 50 publications

(34 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Feng et al . reported that 25OHD was obviously associated with hip fractures in the elderly patients. For each reduction in standard deviation, major osteoporotic fractures increased by 40%.…”

Section: Discussionmentioning

confidence: 94%

“…Annweiler and Beauchet found that the number of elderly patients who experienced falls and tumbles with a serum 25OHD below 20 ng/mL significantly increased the risk of fracture 19 . Feng et al reported that 25OHD was obviously associated with hip fractures in the elderly patients 20 . For each reduction in standard deviation, major osteoporotic fractures increased by 40%.…”

Section: Relationship Between Serum 25ohd Level and Brittlementioning

confidence: 99%

See 1 more Smart Citation

Analysis of Related Factors of Brittle Hip Fracture in Postmenopausal Women with Osteoporosis

Zhuang

Wang

et al. 2020

Orthopaedic Surgery

View full text Add to dashboard Cite

Objective To investigate the effects of age, body mass index (BMI), bone mineral density (BMD), and levels of serum 25‐hydroxyvitamin D (25OHD) on hip fracture on the condition of the bone density of femoral neck having reached the threshold of osteoporosis. Methods A total of 252 postmenopausal women patients, whose bone density had reached the threshold of osteoporosis and age ≥50 years (50–98 years), collected from the Second Affiliated Hospital of Fujian Medical University from January 2015 to December 2018, were performed by retrospective analysis. According to whether or not they had a hip fracture, including femoral neck fracture or intertrochanteric fracture, the patients were divided into two groups, including 117 cases (50–84 years old) in the non‐hip fracture group and 135 cases (57–98 years old) in the hip fracture group. BMD was measured by Hologic Discovery A DXA bone mineral densitometer. Levels of serum 25OHD were detected by ROCHE detection instrument. Comparisons of age, BMI, bone density of femoral neck, and levels of serum 25OHD between the two groups were performed by using the Student's t‐test. Furthermore, the statistically significant factors were analyzed by multiple regression analysis to investigate the independent risk factors of hip fracture. Results The group without hip fracture: 117 cases; average age: 67.4 ± 8.5 years; BMI: 22.3 ± 3.2 kg/m2; bone density of femoral neck: (0.504 ± 0.067) g/cm2; T‐value of femoral neck: −3.1 ± 0.6; levels of serum 25OHD: (24.9 ± 8.5) ng/mL. The group with brittle hip fracture: 135 cases; average age: 80.7 ± 7.6 years; BMI: 20.3 ± 3.5 kg/m2; bone density of femoral neck: (0.426 ± 0.077) g/cm2; T‐value of femoral neck: −3.8 ± 0.7; levels of serum 25OHD: (15.9 ± 8.9) ng/mL. Age, BMI, bone density of femoral neck, and 25OHD level of the group without hip fracture were markedly lower than hip fracture group (P < 0.05). The results of logistic regression analysis suggested that age, bone density of femoral neck, and levels of serum 25OHD were independent risk factors for fragile hip fracture on the condition of the bone density of femoral neck having reached the threshold of osteoporosis. Conclusion Higher age, lower levels of bone density and 25OHD are the main risk factors of hip fracture on the condition of the bone density of femoral neck having reached the threshold of osteoporosis.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Relationship Between Serum 25ohd Level and Brittlementioning

confidence: 99%

Analysis of Related Factors of Brittle Hip Fracture in Postmenopausal Women with Osteoporosis

Zhuang

Wang

et al. 2020

Orthopaedic Surgery

View full text Add to dashboard Cite

show abstract

“…Hepatic encephalopathy is also associated with an increased risk of fall, which will increase the fracture risk. In addition, the limited ability to make 25‐hydroxy (OH) D in cirrhotic patients may increase fracture risks …”

Section: Discussionmentioning

confidence: 99%

“…In addition, the limited ability to make 25-hydroxy (OH) D in cirrhotic patients may increase fracture risks. 23,24 This study has several limitations which should be noted.…”

Section: Sensitivity and Subgroup Analysesmentioning

confidence: 94%

The association between liver cirrhosis and fracture risk: A systematic review and meta‐analysis

Liang

Meng

Yang

et al. 2018

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

“…However, Ginsberg et al [11] showed that there is no association between serum 25(OH)D and hip fractures, and that by Barbour et al [12] showed that serum 25(OH)D is unrelated with the occurrence of any non-spine fractures. In a 2017 metaanalysis on the relationship between serum 25(OH)D and the risk of total fractures, it was found that serum 25(OH)D is inversely proportionate to the incidence of total fractures [13].…”

Section: Introductionmentioning

confidence: 99%

The relationship between serum vitamin D and fracture risk in the elderly: a meta-analysis

Wang

Chen

et al. 2020

J Orthop Surg Res

View full text Add to dashboard Cite

Background: The incidence of osteoporotic fractures has increased rapidly, and because of the poor prognosis and high mortality associated with osteoporotic fractures, they remain a prospective research area globally. One way to reduce their incidence is to investigate their intervention risk factors in the elderly. Hence, this study explores the correlation between serum 25-hydroxyvitamin D [25(OH)D] levels and osteoporotic fractures in elderly patients through a meta-analysis. Methods: We conducted our literature search mainly in PubMed and Embase for identifying studies that investigated the relationship between serum 25(OH)D levels and the risk for osteoporotic fractures. We performed categorical analysis, heterogeneity checks, publication bias analysis, and subgroup analyses. Results: In total, 20 studies were included, of which 4 were case-cohort studies and 16 were cohort studies. A total of 41,738 patients from 20 studies were included in the meta-analysis, of which 5916 had fractures, including 3237 hip fractures. By combining the lowest and highest categories of relative risks (RRs) and 95% confidence intervals (CIs), it was suggested that lower serum 25-hydroxyvitamin D levels may be a risk factor for fractures. RR (95% CI) for total and hip fractures were 1.11 (0.99, 1.24) and 0.89 (0.80, 0.98) after adjustments. Conclusions: Our study showed that compared to low serum 25(OH)D levels, high serum 25(OH)D levels reduce the risk of hip fractures in the patients aged 60 years or older. In contrast, serum 25(OH)D has no significant relationship with total fracture risk.

show abstract

The associations between serum 25-hydroxyvitamin D level and the risk of total fracture and hip fracture

Abstract: Our study suggests that low serum 25(OH) vitamin D level is associated with increased risks of total and hip fractures. In the analyzed studies, the per SD decrease in serum 25(OH) vitamin D level was associated with the hip fracture risk but not with the total fracture risk.

Cited by 50 publications

References 58 publications

Analysis of Related Factors of Brittle Hip Fracture in Postmenopausal Women with Osteoporosis

Analysis of Related Factors of Brittle Hip Fracture in Postmenopausal Women with Osteoporosis

The association between liver cirrhosis and fracture risk: A systematic review and meta‐analysis

The relationship between serum vitamin D and fracture risk in the elderly: a meta-analysis

Contact Info

Product

Resources

About