The associations between serum high-density lipoprotein cholesterol levels and malignant behavior in pancreatic neuroendocrine neoplasms

Quan, Li; Liu, Yongkang; Cui, Wenjing; Wang, Xinru; Zhang, Weixiao; Wang, Zhongqiu; Guo, Chuangen; Lu, Chin‐Song; Hu, Feixiang; Chen, Xiao

doi:10.1186/s12944-022-01669-z

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…A recent study showed that triglycerides (TG)/high-density lipoprotein (HDL) ratio may have potential in identifying bladder cancer [4]. Low serum HDL levels are also associated with malignant behavior of pancreatic neuroendocrine neoplasms [14]. In addition, studies also showed that oxidized low-density lipoprotein-cholesterol (LDL-c), or high total serum cholesterol (TC) and HDLcholesterol (HDL-c) was associated with more aggressive cancer [15,16].…”

Section: Introductionmentioning

confidence: 99%

The association between serum lipid levels and histological type of breast cancer

Wang

et al. 2022

Eur J Med Res

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Background Studies have investigated the association between serum lipids level or apolipoprotein levels and breast cancer (BC) risk. However, the relationship between serum lipids level and apolipoprotein levels and histological type of breast cancer remains unclear. This study was aimed to explore the association between serum lipids level and the histological type of BC, particularly to estrogen receptor (ER) and progesterone receptor (PR) positive BC. Materials and methods 220 cases of pathology-confirmed BC were retrospectively collected in this study. Patients’ demographic information, clinical data, and pathological features were obtained from medical records. Serum levels including high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein-cholesterol (LDL-c), total cholesterol (TC), triglyceride (TG), apolipoprotein A (ApoA), ApoB, ApoE and lipoprotein a(LP(a)) were collected before treatment. Logistic regression analyses were used to show the association between serum lipids and subtypes of BC. Receiver operating characteristic (ROC) curves were generated to analyze the predictive performance. Results There were 70 ER-negative and 73 PR-negative BC. Patients with ER-negative BC had higher HDL-c, higher LDL-c, and higher LP(a) than those in ER-positive one (p < 0.05). Patients with PR-negative BC were more likely to have high LDL-c and high LP(a) levels than patients with PR-positive one (p < 0.05). Multivariate logistic regression analysis showed that serum HDL-c (odds ratio (OR): 0.27, 95% confidence interval (CI) 0.10–0.76), LDL-c (OR: 0.19, 95%CI 0.04–0.93) and LP(a) (OR: 0.23,95%CI 0.07–0.80) levels were negatively associated with ER-positive BC, and serum HDL-c and LDL-c levels were significantly negatively associated with PR-positive BC (OR: 0.32, 95%CI 0.12–0.82; OR: 0.14, 95%CI 0.03–0.77). In addition, ER and PR positive BC was negatively associated with serum HDL-c and LDL-c levels (OR = 0.39, 95% CI 0.17–0.91; OR = 0.22, 95% CI 0.06–0.85) after adjusting with confounders. Serum HDL-c level (OR = 0.13, 95% CI 0.02–0.87) was still independently associated with ER and PR positive BC in postmenopausal women. The area under the curves (AUCs) of HDL-c to identify ER-positive BC, PR-positive BC, and ER and PR positive BC were 0.65 (95%CI 0.58–0.73, P < 0.01), 0.62 (95%CI 0.54–0.69, P < 0.01) and 0.64 (95%CI 0.56–0.72, P < 0.01), respectively. Conclusions Serum HDL-c and LDL-c levels were related to ER or PR positive BC. Lipid levels may also have acceptable performance in identifying BC histological type.

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Section: Introductionmentioning

confidence: 99%

The association between serum lipid levels and histological type of breast cancer

Wang

et al. 2022

Eur J Med Res

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The association between non-HDL cholesterol and high-grade pancreatic neuroendocrine neoplasms

Zhou,

Zhu,

Qin

et al. 2024

Endocrine

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The characteristics of serum lipid spectrum in PanNENs and its correlation with clinicopathological features and prognosis

et al. 2023

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BackgroundThe role of dyslipidemia in pancreatic neuroendocrine tumors (PanNENs) is unclear. The aim of this study is to analyze the characteristics of serum lipid spectrum in PanNENs, and the effect of the variation in lipid profile on the development of PanNENs clinicopathological features and prognosis.MethodsAll PanNENs patients between November 2012 and September 2020 in the authors’ research center were identified from patient medical records and databases. A total of 185 with PanNENs patients were ultimately included in this study, including 100 nonfunctional PanNENs and 85 insulinomas. Clinicopathologic features, serum lipid level and overall survival results were retrospectively analyzed using statistical methods.ResultsIn 185 PanNENs, 95 (51.4%) patients appear to have dyslipidemia. Patients with insulinoma had a lower proportion of abnormal HDL than those with nonfunctional PanNENs (10.6% vs 23%, P=0.026). The mean serum HDL levels of insulinomas were 0.131 mmol/L higher than the NF-PanNENs (1.306 ± 0.324 vs 1.175 ± 0.315, P=0.006). In multivariate logistic analysis, high levels of HDL are negatively correlated to tumor size (OR 0.233, 95% CI: 0.069-0.790, P=0.019), but HDL was not associated with pathological grade or metastasis. And a correlation has been found between hypercholesterolemia and the original location of the tumor (OR:0.224, 95%CI: 0.066-0.753, P =0.016). In addition, the outcome of the survival analysis revealed that dyslipidemia did not influence the prognosis of PanNENs patients (P>0.05).ConclusionsHDL was negatively correlated with the tumor size of PanNENs. The serum HDL level of insulinoma patients is higher than nonfunctional PanNENs.

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The associations between serum high-density lipoprotein cholesterol levels and malignant behavior in pancreatic neuroendocrine neoplasms

Cited by 3 publications

References 41 publications

The association between serum lipid levels and histological type of breast cancer

The association between serum lipid levels and histological type of breast cancer

The association between non-HDL cholesterol and high-grade pancreatic neuroendocrine neoplasms

The characteristics of serum lipid spectrum in PanNENs and its correlation with clinicopathological features and prognosis

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