The associations between the environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer risk and progression

Liu, Sijin; Zhang, Shuping; Qu, Chen; Liu, Wei; Du, Yuguo

doi:10.1007/s11426-010-0149-1

Cited by 10 publications

(3 citation statements)

References 44 publications

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“…However, these very characteristics make them resistant to natural degradation and persistent in the environment, and therefore they have been classified as persistent organic pollutants (POPs), along with several other compounds . Their natural propensity to bioaccumulate and biomagnify, combined with their toxicity, leads them to cause cancer and other adverse health effects on the immune system, reproductive system, nervous system, and endocrine system . Even though production was banned more than two decades ago in several countries (76/403/EEC which refers to the directive of the council of the European community), trace levels of PCBs are still present in the environment, continuing to pose a major threat to public health .…”

mentioning

confidence: 99%

Selection and Characterization of PCB-Binding DNA Aptamers

Mehta

Rouah-Martin²,

Dorst³

et al. 2012

Anal. Chem.

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Polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) that resist natural degradation and bioaccumulate in nature. Combined with their toxicity, this leads them to cause cancer and other health hazards. Thus, there is a vital need for rapid and sensitive methods to detect PCB residues in food and in the environment. In this study, PCB-binding DNA aptamers were developed using PCB72 and PCB106 as targets for aptamer selection. Aptamers are synthetic DNA recognition elements which form unique conformations that enable them to bind specifically to their targets. Using in vitro selection techniques and fluorometry, an aptamer that binds with nanomolar affinity to both the PCBs has been developed. It displayed high selectivity to the original target congeners and limited affinity toward other PCB congeners (105, 118, 153, and 169), suggesting general specificity for the basic PCB skeleton with varying affinities for different congeners. This aptamer provides a basis for constructing an affordable, sensitive, and high-throughput assay for the detection of PCBs in food and environmental samples and offers a promising alternative to existing methods of PCB quantitation. This study therefore advances aptamer technology by targeting one of the highly sought-after POPs, for the first time ever recorded.

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confidence: 99%

Selection and Characterization of PCB-Binding DNA Aptamers

Mehta

Rouah-Martin²,

Dorst³

et al. 2012

Anal. Chem.

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“…Several earlier studies suggested a positive association [38][39][40][41][42][43][44], other studies showed no increased breast cancer risk [45][46][47][48][49][50]. More recent data suggested that the CYP1A1 m2 polymorphisms might add an increased risk to the etiology of breast cancer in women with environmental exposure to PCBs [51]. PCBs enhance the metastatic propensity of breast cancer cells by activating the Rho associated protein kinase (ROCK) signalling that is dependent on ROS induced by PCBs.…”

Section: Polychlorinated Biphenylsmentioning

confidence: 99%

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Kráľová

Jampílek

2015

Ecological Chemistry and Engineering S

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Breast cancer is the most frequent cancer in women. It is believed that among the causes of breast cancer, hereditary factors account for only 5-10% of risk and the environmental exposures to environmental contaminants account for an additional 30-50% of risk. This paper summarizes findings related to the risk of breast cancer due to exposure to following environmental contaminants: polycyclic aromatic hydrocarbons, polychlorinated biphenyls and dioxins, organochlorine pesticides, organophosphorous pesticides, bisphenol A, phthalates, parabens, organic solvents, atmospheric pollutants, alkylphenols, metals, ionizing radiation, electromagnetic field and light pollution. Results obtained in in vitro experiments with breast cancer cell lines and in vivo with model rodents as well as in population based case-control studies are presented and the mode of action of individual environmental contaminants on mammary gland is discussed. Attention is also devoted to the effects of the timing of exposure to environmental contaminants (mainly exposition during development of the mammary gland) on breast cancer risk. Outcomes of professional exposure to some environmental contaminants on breast cancer risk are analysed as well.

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“…[1][2][3][4] However, concentration levels of PCBs in contaminated environment are typically low in complex matrices. 5,6 Proper sampling and enrichment methods have to be employed to recover sufficient targeted compounds from suspended particulate matter or water phase.…”

Section: Introductionmentioning

confidence: 99%

Determination of polychlorinated biphenyls in seawater using headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry with the aid of experimental design

Song

Chen

et al. 2012

J. Braz. Chem. Soc.

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Uma abordagem de pré-tratamento simples e confiável em cromatografia gasosa acoplada à espectrometria de massa (GC-MS) foi desenvolvida para a limpeza simultânea da água do mar e concentração de bifenilas policloradas (PCBs), com 1 a 8 átomos de cloro, baseada na combinação da oxidação de KMnO 4 com amostragem de headspace e microextração em fase sólida (SPME). Os fatores que afetam o processo de extração foram estudados usando uma abordagem multivariada. Sob condições ótimas, tais como fibra de PDMS com 7 μm, 78 °C de temperatura de extração, 33 min de tempo de extração e 8 mL de volume, os limites de detecção do método variaram entre 0,3 e 7,5 ng L -1 e os valores de precisão variaram entre 3,9 e 9,9%, para um nível de fortificação de 0,05 μg L -1 de PCBs. Ácidos húmicos da água do mar exibiram efeitos negativos marcantes; as recuperações de PCBs foram significativamente melhoradas, especialmente para os mais lipofílicos, CB171 e CB201, de 35% e 49% para 78% e 89%, respectivamente, após o pré-tratamento das amostras da água do mar com KMnO 4 em pH 6. O método desenvolvido mostrou-se simples, rápido, confiável e aplicável para a determinação de diferentes PCBs em água do mar contendo grandes quantidades de substâncias húmicas.A simple and reliable pretreatment approach in gas chromatography-mass spectrometry (GC-MS) was developed for concurrent clean-up of seawater and the concentration of lipophilic polychlorinated biphenyls (PCBs) with 1-8 chlorine atoms based on the combination of KMnO 4 oxidation with headspace sampling and solid-phase microextraction (SPME). Factors affecting the extraction process were studied using a multivariable approach. Under optimum conditions such as PDMS 7 μm of fiber, 78 °C of extraction temperature, 33 min of extraction time, 8 mL of volume, the limits of detection ranged from 0.3 to 7.5 ng L -1 and precisions were between 3.9 and 9.9% at spiked 0.05 μg L -1 PCBs. Humic acids in seawater exhibited remarkably negative effects; recoveries of PCBs were significantly improved, especially for more lipophilic CB171 and CB201 from 35% and 49% to 78% and 89%, respectively, after KMnO 4 pretreating seawater samples at pH 6. The developed method was demonstrated to be simple, rapid, reliable and applicable for determining different PCBs in seawater containing large amounts of humic substances.

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The associations between the environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer risk and progression

Cited by 10 publications

References 44 publications

Selection and Characterization of PCB-Binding DNA Aptamers

Selection and Characterization of PCB-Binding DNA Aptamers

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Determination of polychlorinated biphenyls in seawater using headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry with the aid of experimental design

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