The associations between thyroid-related hormones and the risk of thyroid cancer: An overall and dose-response meta-analysis

Wang, Zheng; Lin, Yiguang; Jiang, Yixian; Fu, Rong; Wang, Yabing; Zhang, Qian

doi:10.3389/fendo.2022.992566

Cited by 9 publications

(4 citation statements)

References 61 publications

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“…Many studies have shown the association of thyroid dysfunction with thyroid carcinoma as well as other cancer risks. [22][23][24] Although previous studies like a cohort study showed a link between subclinical hypothyroidism with an increased risk of thyroid cancer incidence. 25 On the other hand, previous results also revealed that untreated subclinical hypothyroidism may be associated with an increased risk of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Navigating Thyroid Dysfunction and Comorbidities Among University Students in Abbottabad, Pakistan – A Cross-Sectional Evaluation of Screening Tool for Thyroid Dysfunction

Iqbal,

Azhar,

Murtaza

et al. 2023

IJGM

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Background Thyroid dysfunction has a direct role in diagnosing, and assessment and indicates the development of thyroid carcinoma. This study aimed to assess thyroid dysfunction through medical camps in different age and sex groups in students of Comsats University Abbottabad Pakistan. Methods In this study, a cross-sectional survey design was used. For data collection, a two-day medical camp was set in the Comsats University Abbottabad campus. The students were examined physically for symptoms of thyroid dysfunction using the survey questionnaire specifically designed for this study. Results The current research revealed that 78 out of 1032 students, or 7.6% of the population, had thyroid disease. Although 39.3% (=406) were found to have low risk, followed by 36.7% (n=379) had moderate risk and 23.9% (n=247) had high risk of thyroid dysfunction. Altogether, 6.1% (n=63) of the students had high blood pressure (BP), 3.2% (n=33) had high cholesterolemia, 3.4% (n=33) had angina, and 0.9% (n=9) had diabetes mellitus (DM). In relation, students who exhibit signs and symptoms that last longer than five weeks include 42.2% (n=435) who felt the need for excessive sleep, 35.3% (n=364) who felt tired, 36.8% (n=380) who had trouble concentrating and 30.1% (n=311) who had palpitations. The high risk of thyroid being seen predominantly in students between the ages of 15–20 years (31.2%, n=148), as opposed to other age groups ( p =0.001). Similar to this, women having a higher risk of thyroid disease (26.5%) than men (22.8%) ( p =0.001). Conclusion In conclusion, few students suffer with thyroid found to have high risk of thyroid disease. This method of questionnaire-based screening for thyroid dysfunction is cost-effective, with no additive risk of adverse effects from excessive screening, and could help in the early detection of thyroid and help avoid excess costs related to thyroid dysfunction and cancer screening.

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Section: Discussionmentioning

confidence: 99%

Navigating Thyroid Dysfunction and Comorbidities Among University Students in Abbottabad, Pakistan – A Cross-Sectional Evaluation of Screening Tool for Thyroid Dysfunction

Iqbal,

Azhar,

Murtaza

et al. 2023

IJGM

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“…A growing number of studies have reported the association between thyroid hormones and PTC, 29–33 but no clear conclusions have been drawn. Higher FT4 levels were reported to be positively associated with thyroid cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Various Ultrasound-Based Malignant Risk Stratification Systems on an Occasion for Assessing Thyroid Nodules in Hashimoto’s Thyroiditis

Zhao¹,

Zhang²,

Xu³

2023

IJGM

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Purpose To compare the diagnostic performance and unnecessary ultrasound-guided fine-needle aspiration (US-FNA) biopsy rate of the 2015 American Thyroid Association (ATA), 2016 Korean Society of Thyroid Radiology (KSThR), and 2017 American College of Radiology (ACR) guidelines for patients with and without Hashimoto’s thyroiditis (HT). Patients and Methods This retrospective study included 716 nodules from 696 consecutive patients, which were classified using the categories defined by the three guidelines: ATA, KSThR, and ACR. The malignancy risk in each category was calculated and the diagnostic performance and unnecessary fine-needle aspiration (FNA) rates of the three guidelines were compared. Results In total, 426 malignant and 290 benign nodules were identified. Patients with malignant nodules had lower total thyroxine levels and higher thyroid-stimulating hormone, thyroid peroxidase antibody, and thyroglobulin antibody levels than those without malignant nodules (all P <0.01). The margin difference was significant in non-HT patients ( P <0.01), but comparable in HT patients ( P =0.55). The calculated malignancy risks of high and intermediate suspicion nodules in the ATA and KSThR guidelines and moderately suspicious nodules in the ACR guidelines were significantly lower in non-HT patients compared with HT patients ( P <0.05). The ACR guidelines showed the lowest sensitivity, highest specificity, and lowest unnecessary FNA rates in patients with and without HT. Compared to non-HT patients, HT patients had significantly lower unnecessary FNA rates ( P <0.01). Conclusion HT was associated with a higher malignancy rate of thyroid nodules with intermediate suspicion according to the ATA, KSThR, and ACR guidelines. The three guidelines, especially ACR, were likely to be more effective and could allow a greater reduction in the percentage of benign nodules biopsied in patients with HT.

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“…Classical TSH actions are mainly mediated through the Gαs-adenylyl cyclase-protein kinase A-cyclic adenosine monophosphate pathway, which is associated with T4 and T3 production and thyrocyte proliferation. In this sense, several meta-analyses had associated higher serum TSH concentration with higher odds of TC [ 69 - 71 ].…”

Section: Probable Molecular Mechanisms Associated Between Ht and Dtcmentioning

confidence: 99%

Autoimmune Thyroid Disease and Differentiated Thyroid Carcinoma: A Review of the Mechanisms That Explain an Intriguing and Exciting Relationship

Vargas-Uricoechea

2024

World J Oncol

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Autoimmune thyroid disease is a complex and highly frequent disease, where a wide variety of genetic, epigenetic and environmental factors (among others) come together and interact, and is characterized by the presence of two clinical outcomes: hypothyroidism (in Hashimoto’s thyroiditis) and hyperthyroidism (in Graves-Basedow disease). For its part, differentiated thyroid carcinoma (mainly papillary carcinoma) is the most common type of cancer affecting the thyroid (and one of the most prevalent worldwide). An important co-occurrence between autoimmune thyroid disease and differentiated thyroid carcinoma has been documented. In this article, studies that have evaluated possible associations and relationships between autoimmune thyroid disease and differentiated thyroid cancer are systematically described and summarized. To date, the underlying mechanism that explains this association is inflammation; however, the characteristics and designs of the studies evaluated do not yet allow a causal relationship between the two entities to be established. These aspects have made it difficult to establish “causality” in the continuum of the pathogenesis between both conditions.

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The associations between thyroid-related hormones and the risk of thyroid cancer: An overall and dose-response meta-analysis

Cited by 9 publications

References 61 publications

Navigating Thyroid Dysfunction and Comorbidities Among University Students in Abbottabad, Pakistan – A Cross-Sectional Evaluation of Screening Tool for Thyroid Dysfunction

Navigating Thyroid Dysfunction and Comorbidities Among University Students in Abbottabad, Pakistan – A Cross-Sectional Evaluation of Screening Tool for Thyroid Dysfunction

Comparison of Various Ultrasound-Based Malignant Risk Stratification Systems on an Occasion for Assessing Thyroid Nodules in Hashimoto’s Thyroiditis

Autoimmune Thyroid Disease and Differentiated Thyroid Carcinoma: A Review of the Mechanisms That Explain an Intriguing and Exciting Relationship

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