The Asthma COPD Overlap Syndrome (ACOS)

Bujarski, Stephen; Parulekar, Amit; Sharafkhaneh, Amir; Hanania, Nicola A.

doi:10.1007/s11882-014-0509-6

Cited by 64 publications

(52 citation statements)

References 82 publications

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“…Az irodalomban elérhető adatok alapján számos kritéri-umrendszert használnak az ACOS definíciójának meghatározásához [54]. A GINA-GOLD dokumentumokban megfogalmazott új definíció alapján az ACOS olyan változó karakterisztikájú légúti áramláskorlátozottsággal jellemzett kórkép, amelynek tulajdonságai általában az asthma és a COPD jellemzőivel párosulnak.…”

Section: Definíció éS Diagnosztikai Megfontolásokunclassified

Asthma-COPD overlap szindróma

Odler

Müller

2016

Orvosi Hetilap

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Az obstruktív tüdőbetegségek világszerte jelentős népegészségügyi problémát jelentenek, magas prevalenciájuk és a társadalmat érintő nagy szocioökonómiai költségeik miatt. Az asthma bronchiale és a krónikus obstruktív tüdőbeteg-ség krónikus légúti gyulladással járó betegségek, amelyeket légúti obstrukció jellemez, azonban külön nozológiai entitások, figyelembe véve kialakulásukat, diagnosztikájukat, a terápiás megfontolásokat és prognosztikai jellemzői-ket. A két betegség együttesen is előfordulhat, vagy az egyik állapot képes a másik jellemzőit felvéve, abba átalakulni. Ezt a kevert asthma-COPD fenotípust nevezzük asthma-COPD overlap szindrómának, amelyet úgy jellemeznek, hogy olyan perzisztáló légúti áramláskorlátozottsággal járó betegség, amely rendelkezik mind az asthma, mind a krónikus obstruktív tüdőbetegség egyes jellemzőivel. A szindróma az elmúlt években jelentős figyelmet kapott, azonban a betegek nagy része mostanáig kizárásra került a klinikai és légúti gyógyszer-hatásossági vizsgálatokból, így a jól meghatározott klinikai jellemzők és a megfelelő terápia továbbra sem ismertek. Az összefoglaló közlemény elsődleges célja az elmúlt években leírt patofiziológiai és klinikai jellemzők, terápiás megfontolások és irodalmi újdonságok bemutatása. Orv. Hetil., 2016, 157(33), 1304-1313. Kulcsszavak: ACOS overlap szindróma, COPD, asthma bronchiale, obstruktív, terápia Asthma-COPD overlap syndromeObstructive lung diseases represent a major health problem worldwide due to their high prevalence associated with elevated socioeconomic costs. Bronchial asthma and chronic obstructive pulmonary disease are chronic obstructive ventilatory disorders with airway inflammation, however they are separate nosological entities based on thedifferent development, diagnostic and therapeutic approaches, and prognostic features. However, these diseases may coexist and can be defined as the coexistence of increased variability of airflow in a patient with incompletely reversible airway obstruction. This phenotype is called asthma -chronic obstructive pulmonary disease overlap syndrome. The syndrome is a clinical and scientific challenge as the majority of these patients have been excluded from the clinical and pharmacological trials, thus well-defined clinical characteristics and therapeutic approaches are lacking. The aim of this review is to summarize the currently available literature focusing on pathophysiological and clinical features, and discuss possible therapeutic approaches of patients with asthma -chronic obstructive pulmonary disease overlap syndrome. -nél kisebb erek átmérőjének százalékos ará-nya; AA = afroamerikai; ACOS = asthma-COPD overlap szindróma; ACT = asthmakontrollteszt; BHR = fokozott válaszadó készség; BMI = testtömegindex; BODE-index = body mass index (testtömegindex), airflow obstruction (légúti obstrukció), dyspnea and exercise capacity (légszomj és terhelési kapacitás); BOLD = Burden of Obstructive Lung Diseases; CAT = COPD Assessment Test; COPD = krónikus obstruktív tüdőbe-tegség; CRP = C reaktív protei...

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Section: Definíció éS Diagnosztikai Megfontolásokunclassified

Asthma-COPD overlap szindróma

Odler

Müller

2016

Orvosi Hetilap

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“…It is difficult to clinically distinguish COPD from asthma, and therefore these diagnoses often overlap (asthma-COPD overlap syndrome). In previous research showed the prevalence of asthma-COPD overlap syndrome was 1.8-56.0% [25][26][27][28]. Therefore, we did not remove patients with asthma from the study population.…”

Section: Comparison With Similar Studiesmentioning

confidence: 99%

Development of a chronic obstructive pulmonary disease severity classification system using a Japanese health insurance claims database

Konomura

Nagai

Akazawa

2014

JARH

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“…Recently, a combination of these two diseases, the so-called asthma-COPD intersection (ACP), characterized by more expressed symptoms, frequent exacerbations and worse prognosis in comparison with two pathologies separately [1,2].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Functional Condition of Respiratory Muscles of Patients With a Complicated Bronchial Asthma Pathology and Chronic Obstructive Pulmonary Diseases

Feschenko

Nazarenko

2017

EUREKA: Health Sciences

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The aim of the research was to study the functional state of respiratory muscles and neuro-respiratory drive in patients with a combined pathology of bronchial asthma and chronic obstructive pulmonary disease. The functional condition of the respiratory muscles and the tone of the respiratory centre were determined with the help of a device for occlusion spirometry. Also, the patient was observed with a spirometry, a general plethysmography of the body. Materials and methods. 140 patients with combined broncho-obstructive pathology, 34 patients with asthma and 17 patients with COPD were examined. Spirometry, general plethysmography of the body and occlusion spirometry were provided for all patients. Results show a decrease in muscle strength of breath in all categories of patients with broncho-obstructive diseases, especially expressed in patients with bronchial asthma and asthma-COPD intersection. The muscle strength of breath was maintained with a significant increase in COPD patients compared with those with bronchial asthma. With increasing broncho-obstruction in patients with asthma-COPD intersection, there was a progressive and reliable decrease in muscle strength for breath and expiration, as well as a tendency to increase neuron respiratory drive. In patients with asthma-COPD intersection with more expressed symptoms revealed a significant and reliable weakening of muscle strength for breath and increased neuro-respiratory drive. During the work were obtained reliable links of the parameters of respiratory muscle strength not only with the parameters of pulmonary volume and bronchial patency, but also with the degree of neutrophilic inflammation in this category of patients. Conclusions The obtained data on failure of the functional state of the respiratory muscles and the neuro-respiratory drive can be used in the development of rehabilitation programs for the management of patients with combined broncho-obstructive pathology.

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The Asthma COPD Overlap Syndrome (ACOS)

Cited by 64 publications

References 82 publications

Asthma-COPD overlap szindróma

Asthma-COPD overlap szindróma

Development of a chronic obstructive pulmonary disease severity classification system using a Japanese health insurance claims database

Evaluation of Functional Condition of Respiratory Muscles of Patients With a Complicated Bronchial Asthma Pathology and Chronic Obstructive Pulmonary Diseases

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