The Astrocytic Contribution in ALS: Inflammation and Excitotoxicity

Introductory Chapter: Introduction to Update in Amyotrophic Lateral Sclerosis and Review of this Condition in Sportsmen

“…New genes have been recently linked with ALS including TDP43 and FUS, suggesting a possible role for RNA metabolism in disease pathogenesis and special efforts are underway to test therapies aimed at modifying the glial cell population in hopes of slowing ALS disease progression and extending patient survival [86]. Astrocytes clearly contribute to ALS decrease progression in both neuroinflammation and excitotoxicity [87].…”