The bacterial association with oral cavity and intra-abdominal abscess after gastrectomy

Abstract

Background Perioperative oral management has been reported to be effective for preventing postoperative infectious complications. In addition, severe periodontal disease was identified as the significant risk factor for complications after gastrointestinal surgery. We investigated the bacteriological association between the periodontal pocket, stomach mucosa and drainage fluid to determine whether oral bacteria directly cause intra-abdominal infection after gastrectomy. Methods Patients who were scheduled to undergo surgery for gastric cancer were prospectively enrolled. We evaluated the similarity of bacterial strains in periodontal pocket, stomach mucosa and fluid from drainage tube. Gingival crevicular fluid and dental plaque were collected from the periodontal pocket and cultured to detect bacteria. Specimens from the resected stomach were collected and used for bacterial culturing. Drainage fluid from the abdominal cavity was also cultured. Results All of 52 patients were enrolled. In the periodontal pocket, α-Streptococcus spp., Neisseria sp., and Prevotella sp. were mainly detected. Bacterial cultures in the stomach mucosa were positive in 26 cases. In 20 cases (76.9%), the detected strains were the same as those in the periodontal pocket. Six patients had the postoperative intra-abdominal infection after gastrectomy, and the same bacterial strains was detected in both of drainage fluid and periodontal pocket in two patients with severe periodontal disease. Conclusions We found the bacteriological association that same strain detected in periodontal pocket, stomach and in intra-abdominal drainage fluid after gastrectomy in patients with periodontal disease.

Nomogram of intra-abdominal infection after surgery in patients with gastric cancer: A retrospective study

“…The most common microorganism was Streptococcus anginosus , Enterococcus faecalis , and Klebsiella pneumoniae . Streptococcus anginosus is one of the common colonized bacteria of the oropharynx, which can migrate to the digestive tract and become a pathogenic bacteria of postoperative intra-abdominal infection ( 25 , 26 ). Previously, Xiao et al.…”

Multi-omic Profiling Reveals that Intra-abdominal-Hypertension-Induced Intestinal Damage Can Be Prevented by Microbiome and Metabolic Modulations with 5-Hydroxyindoleacetic Acid as a Diagnostic Marker

“…For example, IAH-enriched B. fragilis , Bacteroides eggerthii , and B. ovatus were previously reported to be involved in inflammatory responses in inflammatory bowel disease (IBD) ( 20 – 22 ). Many species of Prevotella and Clostridium enriched in IAH were responsible for intestinal/abdominal infections ( 23 – 28 ). On the other hand, L92-enriched Flavonifractor plautii is beneficial in inhibiting the Th2 immune response to alleviate ovalbumin-induced allergy ( 29 ).…”

Exploring the link between poor oral hygiene and mesh infection after hernia repair: a systematic review and proposed best practices

“…A further study demonstrated the link between the severity of periodontal disease and surgical outcomes of patients undergoing total gastrectomy [14]. Twenty-six out of 52 patients had the same bacteria in their gastric mucosa as in their oral cavity despite prophylactic antibiotic administration.…”