2016
DOI: 10.1186/s12890-016-0324-z
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The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia

Abstract: BackgroundTo identify markers for earlier diagnosis of severe pneumonia, we assess the correlation between serum cytokine profile of children with different pneumonia severity.MethodsIn 25 hospitalized children, 7 with mild pneumonia and 18 with severe pneumonia, the serum concentration of 11 cytokines in three sampling times were dosed. Statistical analysis included parametric and non-parametric tests, Pearson correlation and ROC curve for cut-off definition of cytokines.ResultsAt admission, IL-6 serum levels… Show more

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Cited by 87 publications
(66 citation statements)
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“…When we merge two bacterial groups ( Table 9), we found that one can distinguish between healthy, influenza and bacterial categories with very high accuracy of In several studies IL-6 levels in the serum have been found to correlate with either bacterial infections or disease severity in patients with CAP. [44][45][46][47] Our results also detected increased IL-6 in the urine which was elevated in all pneumonias compared to healthy controls. However, based on the predictive modeling, IL-15 and IL-18 in combination with the metabolome and microbiome data may be more useful for distinguishing bacterial vs viral pneumonias.…”
Section: Predictive Modelingsupporting
confidence: 70%
“…When we merge two bacterial groups ( Table 9), we found that one can distinguish between healthy, influenza and bacterial categories with very high accuracy of In several studies IL-6 levels in the serum have been found to correlate with either bacterial infections or disease severity in patients with CAP. [44][45][46][47] Our results also detected increased IL-6 in the urine which was elevated in all pneumonias compared to healthy controls. However, based on the predictive modeling, IL-15 and IL-18 in combination with the metabolome and microbiome data may be more useful for distinguishing bacterial vs viral pneumonias.…”
Section: Predictive Modelingsupporting
confidence: 70%
“…As the ratio of serum concentrations of IL-6 and IL-10 has been identified as a potential prognostic marker of the severity of different inflammatory conditions, we further investigated the kinetics of these cytokines (de Brito et al, 2016;Nagaki et al, 2000;Stensballe et al, 2009;Taniguchi et al, 1999). We also monitored the serum concentration of TNF, which will be of mixed endogenous and exogenous origin, but in turn can also stimulate secretion of the aforementioned cytokines (Libert, Brouckaert, Shaw, & Fiers, 1990;van Der Poll, Marchant, & van Deventer, 1997).…”
Section: Kinetics Of Tvx-induced Organ Changes Indicates That Liver Imentioning
confidence: 99%
“…Circulating levels of cytokines have been found to be elevated in patients with community acquired pneumonia 13 15 , aid in determining pneumonia severity 16 , and may be able to differentiate causative organisms 17 . However, findings in patients with VAP have been more equivocal 18 20 .…”
Section: Introductionmentioning
confidence: 99%