The Basolateral Nucleus in the System of Reproductive Centers in the Amygdaloid Body of the Brain

Akhmadeev, A. V.; Galieva, L. F.; Kalimullina, L. B.

doi:10.1007/s11055-016-0292-z

Cited by 1 publication

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“…While morphometric differences have been shown in sections of the basal forebrain just anterior to our findings (Dorr et al, 2008; Spring et al, 2007), sex differences have not previously been shown in the more lateral amygdalar regions in mice. This region has been associated with sexually dimorphic behaviors such as pheromone processing, anxiety, and aggression (Akhmadeev et al, 2016). Developing female rats have been shown to display increased rates of cell proliferation (Krebs-Kraft et al, 2010) in the amygdala, but not much is known about the origin of this difference.…”

Section: Discussionmentioning

confidence: 99%

In vivo magnetic resonance images reveal neuroanatomical sex differences through the application of voxel-based morphometry in C57BL/6 mice

et al. 2017

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Behaviorally relevant sex differences are often associated with structural differences in the brain and many diseases are sexually dimorphic in prevalence and progression. Characterizing sex differences is imperative to gaining a complete understanding of behavior and disease which will, in turn, allow for a balanced approach to scientific research and the development of therapies. In this study, we generated novel tissue probability maps (TPMs) based on 30 male and 30 female in vivo C57BL/6 mouse brain magnetic resonance images and used voxel-based morphometry (VBM) to analyze sex differences. Females displayed larger anterior hippocampus, basolateral amygdala, and lateral cerebellar cortex volumes, while males exhibited larger cerebral cortex, medial amygdala, and medial cerebellar cortex volumes. Atlas-based morphometry (ABM) revealed a statistically significant sex difference in cortical volume and no difference in whole cerebellar volume. This validated our VBM findings that showed a larger cerebral cortex in male mice and a pattern of dimorphism in the cerebellum where the lateral portion was larger in females and the medial portion was larger in males. These results are consonant with previous ex vivo studies examining sex differences, but also suggest further regions of interest.

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