The behavioral effect of human mesenchymal stem cell transplantation in cold brain injured rats

Cho, Y. H.; Kim, H. S.; Lee, K. H.; Lee, Y. E.; Chang, Jin Woo

doi:10.1007/978-3-211-35205-2_24

Cited by 10 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Adult stem cells are under intense investigation as a potential therapeutic source of neurons to replace damaged or lost cells in various neurologic diseases. For example, administration of bone marrow-derived mesenchymal stem cells (BM-MSCs) has led to beneficial effects in animal models for several neurodegenerative diseases such as Parkinson's disease, experimental autoimmune encephalomyelitis, and amyotrophic lateral sclerosis [5,6]. Although BM-MSC transplantation has been suggested as a potential therapeutic approach for these and other neurologic disorders [5][6][7][8], the actual therapeutic impact of BM-MSCs on AD pathology and their mechanism of action have not yet been ascertained.…”

Section: Introductionmentioning

confidence: 99%

Intracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer's Disease Mice by Modulation of Immune Responses

et al. 2009

View full text Add to dashboard Cite

Alzheimer's disease (AD) is characterized by the deposition of amyloid-b peptide (Ab) and the formation of neurofibrillary tangles. Transplantation of bone marrow-derived mesenchymal stem cells (BM-MSCs) has been suggested as a potential therapeutic approach to prevent various neurodegenerative disorders, including AD. However, the actual therapeutic impact of BM-MSCs and their mechanism of action in AD have not yet been ascertained. The aim of this study was therefore to evaluate the therapeutic effect of BM-MSC transplantation on the neuropathology and memory deficits in amyloid precursor protein (APP) and presenilin one (PS1) double-transgenic mice. Here we show that intracerebral transplantation of BM-MSCs into APP/PS1 mice significantly reduced amyloid b-peptide (Ab) deposition. Interestingly, these effects were associated with restoration of defective microglial function, as evidenced by increased Ab-degrading factors, decreased inflammatory responses, and elevation of alternatively activated microglial markers. Furthermore, APP/PS1 mice treated with BM-MSCs had decreased tau hyperphosphorylation and improved cognitive function. In conclusion, BM-MSCs can modulate immune/inflammatory responses in AD mice, ameliorate their pathophysiology, and improve the cognitive decline associated with Ab deposits. These results demonstrate that BM-MSCs are a potential new therapeutic agent for AD. STEM CELLS 2010;28:329-343 Disclosure of potential conflicts of interest is found at the end of this article.

show abstract

Section: Introductionmentioning

confidence: 99%

Intracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer's Disease Mice by Modulation of Immune Responses

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Одним из общих признаков МСК является их мультипотентность. Как МСК костного мозга и жировой ткани, так и клетки пуповинной крови (UC-MSCs) обладают потенциалом для дифференцировки в различные типы клеток [21]. Доклинические и клинические испытания указывают на безопасность и восстановление неврологического статуса при терапии МСК.…”

Section: Discussionunclassified

Influence of mesenchymal stem therapy on the behavior of the process of sam-rats with brain injury

Avaliani

Варламовна²,

Fedotova

et al. 2020

Medical academic journal

View full text Add to dashboard Cite

Current research suggests the potential use of mesenchymal stem cells (MSCs) in the treatment of brain injuries. Intravenous administration of MSCs to adult rats with brain injury leads to the restoration of behavioral and neurological status and helps to normalize maternal behavior. In this work, it was shown that a single transplantation of syngeneic mesenchymal stem cells (5 mln) into the bloodstream of female rats with motor deficiency has a corrective effect on the behavior of their offspring: it prevents the development of violations of research and locomotor behavior in the Open Field test and reduces emotional disorders.

show abstract

“…Previous studies have suggested that genetically engineered cells, including brain tissue, embryonic stem cells, adult stem cells and neural stem cells, are capable of integrating and differentiating to restore brain function (9–12). More recently, neural stem cells have been investigated and the results demonstrated that these cells survived and grafted into the host architecture following transplantation into newborn or adult mice or rat brains, and were capable of differentiating into neurons and glia lineages, replacing lost neural cells, improving clinical outcomes after experimental TBI and providing a platform for gene-based therapies (13–19). …”

Section: Introductionmentioning

confidence: 99%

Comparative effect of immature neuronal or glial cell transplantation on motor functional recovery following experimental traumatic brain injury in rats

Quan

Chen

Zhong

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

The present study evaluated the comparative effect of stereotaxically transplanted immature neuronal or glial cells in brain on motor functional recovery and cytokine expression after cold-induced traumatic brain injury (TBI) in adult rats. A total of 60 rats were divided into four groups (n=15/group): Sham group; TBI only group; TBI plus neuronal cells-transplanted group (NC-G); and TBI plus glial cells-transplanted group (GC-G). Cortical lesions were induced by a touching metal stamp, frozen with liquid nitrogen, to the dura mater over the motor cortex of adult rats. Neuronal and glial cells were isolated from rat embryonic and newborn cortices, respectively, and cultured in culture flasks. Rats received neurons or glia grafts (~1×106 cells) 5 days after TBI was induced. Motor functional evaluation was performed with the rotarod test prior to and following glial and neural cell grafts. Five rats from each group were sacrificed at 2, 4 and 6 weeks post-cell transplantation. Immunofluorescence staining was performed on brain section to identify the transplanted neuronal or glial cells using neural and astrocytic markers. The expression levels of cytokines, including transforming growth factor-β, glial cell-derived neurotrophic factor and vascular endothelial growth factor, which have key roles in the proliferation, differentiation and survival of neural cells, were analyzed by immunohistochemistry and western blotting. A localized cortical lesion was evoked in all injured rats, resulting in significant motor deficits. Transplanted cells successfully migrated and survived in the injured brain lesion, and the expression of neuronal and astrocyte markers were detected in the NC-G and GC-G groups, respectively. Rats in the NC-G and GC-G cell-transplanted groups exhibited significant motor functional recovery and reduced histopathologic lesions, as compared with the TBI-G rats that did not receive neural cells (P<0.05, respectively). Furthermore, GC-G treatment induced significantly improved motor functional recovery, as compared with the NC-G group (P<0.05). Increased cytokine expression levels were detected in the NC-G and GC-G groups, as compared with the TBI-G; however, no differences were found between the two groups. These data suggested that transplanted immature neural cells may promote the survival of neural cells in cortical lesion and motor functional recovery. Furthermore, transplanted glial cells may be used as an effective therapeutic tool for TBI patients with abnormalities in motor functional recovery and cytokine expression.

show abstract

The behavioral effect of human mesenchymal stem cell transplantation in cold brain injured rats

Cited by 10 publications

References 35 publications

Intracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer's Disease Mice by Modulation of Immune Responses

Intracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer's Disease Mice by Modulation of Immune Responses

Influence of mesenchymal stem therapy on the behavior of the process of sam-rats with brain injury

Comparative effect of immature neuronal or glial cell transplantation on motor functional recovery following experimental traumatic brain injury in rats

Contact Info

Product

Resources

About