The benefits of clustering in TNF receptor superfamily signaling

Abstract

The tumor necrosis factor (TNF) receptor superfamily is a structurally and functionally related group of cell surface receptors that play crucial roles in various cellular processes, including apoptosis, cell survival, and immune regulation. This review paper synthesizes key findings from recent studies, highlighting the importance of clustering in TNF receptor superfamily signaling. We discuss the underlying molecular mechanisms of signaling, the functional consequences of receptor clustering, and potential therapeutic implications of targeting surface structures of receptor complexes.

Magneto-controlled electrochemical immunosensing platform to assess the senescence-associated GDF-15 marker in colorectal cancer

“…A hypothesis that may justify this result is the tendency of TNFα to form clusters that can somehow trap the target protein, preventing its recognition. 52 As expected, an appropriate dilution of these four nontarget proteins (10 times for hIgG and Hb, and 100 times for HSA and TNFα) provoked minimization of their interference.…”

“…A hypothesis that may justify this result is the tendency of TNFα to form clusters that can somehow trap the target protein, preventing its recognition. 52…”

TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling

“…Organization and arrangement of TNFRSF in homo- and heteromeric complexes into higher-order complexes has profound effect on their signalling capabilities [ 15 , 136 , 137 ] and is often required for efficient apoptosis triggering, as demonstrated with DR5 [ 138 , 139 , 140 ]. Likewise, it has been proposed that, upon cognate ligand binding, DR4, DR5 and Fas form, first of all, trimer complexes whose multimerization or crosslinking with neighbouring trimers occurs via the dimerization between receptor interfaces, either located opposite the ligand-binding interfaces, resulting in a hexameric honeycomb-like structure [ 141 ].…”

Redundancy and absurd names in immunology

“…They regulate immune responses, cell proliferation and survival, and their defects contribute to many human diseases (Vanamee & Faustman, 2023). Members of these two families are so numerous that I will give only four examples here: 1.7.…”

“…From the multiplicity of names, I propose selecting the most informative and most frequently used ones, accompanied by the cluster of differentiation terms.Another family of proteins possessing many names each are those from the tumour necrosis factor receptor superfamily, as well as from the tumour necrosis factor ligand superfamily (1.7–1.10). They regulate immune responses, cell proliferation and survival, and their defects contribute to many human diseases (Vanamee & Faustman, 2023). Members of these two families are so numerous that I will give only four examples here:…”