2024
DOI: 10.3390/ctn8010011
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The Bidirectional Relationship between Sleep and Neurodegeneration: Actionability to Improve Brain Health

Abubaker Ibrahim,
Birgit Högl,
Ambra Stefani

Abstract: Recently, it has become increasingly clear that there is a bidirectional relationship between sleep/circadian rhythms and neurodegeneration. Knowledge about this topic further improved after the description of the glymphatic system, which is mainly active during sleep. Changes in sleep and circadian rhythms are present not only in overt neurodegenerative diseases but also in their early, prodromal, and preclinical phases, supporting that they precede (and contribute to) the development of neurodegeneration. Th… Show more

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“…Disturbances in rhythmicity correlate with disease risk and severity ( Fishbein et al, 2021 ) in a bidirectional manner. This has been validated for numerous pathologies, including immune ( Liu et al, 2017 ; Shivshankar et al, 2020 ; Awuah et al, 2023 ), cardiovascular ( Gottlieb et al, 2019 ; Hayter et al, 2021 ), psychiatric ( Wehr et al, 1987 ; Meyer et al, 2024 ; Scheer and Chellappa, 2024 ), and neurodegenerative disorders ( Fernández-Arcos et al, 2019 ; Sharma et al, 2020 ; Ibrahim et al, 2024 ). Given this wide reach, investigating the circadian dimension of disease is imperative.…”
Section: Research Needsmentioning
confidence: 99%
“…Disturbances in rhythmicity correlate with disease risk and severity ( Fishbein et al, 2021 ) in a bidirectional manner. This has been validated for numerous pathologies, including immune ( Liu et al, 2017 ; Shivshankar et al, 2020 ; Awuah et al, 2023 ), cardiovascular ( Gottlieb et al, 2019 ; Hayter et al, 2021 ), psychiatric ( Wehr et al, 1987 ; Meyer et al, 2024 ; Scheer and Chellappa, 2024 ), and neurodegenerative disorders ( Fernández-Arcos et al, 2019 ; Sharma et al, 2020 ; Ibrahim et al, 2024 ). Given this wide reach, investigating the circadian dimension of disease is imperative.…”
Section: Research Needsmentioning
confidence: 99%