The Binding Mechanism Between Inositol Phosphate (InsP) and the Jasmonate Receptor Complex: A Computational Study

Cui, Mengqi; Du, Juan; Yao, Xiaojun

doi:10.3389/fpls.2018.00963

Cited by 10 publications

(5 citation statements)

References 55 publications

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“…We presume that this mechanism is followed in other stress conditions where other molecule plays a similar role. Similar analysis has been performed in the InsP interaction with the Jasmonate receptor [29]. In this study, it was observed that the binding of InsP with COI1 stabilises the conformation of COI1 and promotes the binding between JAZ1 and COI1.…”

Section: Discussionsupporting

confidence: 72%

Genome-wide identification and interactome analysis of members of two-component system in Banana

et al. 2019

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Background Ethylene signal transduction in plants is conducted by the two-component system (TCS) which consists of histidine kinase (HK), histidine phosphotransferase (HPT) and response regulators (RRs). This system plays an important role in signal transduction during various cellular processes, including fruit ripening and response to multiple environmental cues. Though members of TCS have been identified in a few plants, no detailed analysis has been carried out in banana. Results Through genome-wide analysis, we identified a total of 80 (25 HK, 10 HPT and 45 RR) and 72 (25 HK, 5 HPT and 42 RR) TCS genes in Musa acuminata and Musa balbisiana respectively. The analysis of identified genes revealed that most of the genes are highly conserved however; there are subtle divergences among various members. Comparative expression analysis revealed an involvement of a set of TCS members during banana fruit ripening. Co-expression network analysis identified a working TCS module with direct interactions of HK-HPT and RR members. The molecular dynamics analysis of TCS module showed a significant change in structural trajectories of TCS proteins in the presence of ethylene. Analysis suggests possible interactions between the HK-HPTs and RRs as well as other members leading to banana fruit ripening. Conclusions In this study, we identified and compared the members of TCS gene family in two banana species and showed their diversity, within groups on the basis of whole-genome duplication events. Our analysis showed that during banana fruit ripening TCS module plays a crucial role. We also demonstrated a possible interaction mechanism of TCS proteins in the presence and absence of ethylene by molecular dynamics simulations. These findings will help in understanding the functional mechanism of TCS proteins in plants in different conditions. Electronic supplementary material The online version of this article (10.1186/s12864-019-6050-1) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 72%

Genome-wide identification and interactome analysis of members of two-component system in Banana

et al. 2019

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“…JA is a phytohormone critical for environmental and pathogen defense signaling as well as plant physiology [68]. Similar to auxin signaling with TIR1, JA is also perceived by interactions between F-box protein, coronatine-insensitive 1 (COI1), and the JA zim domain (JAZ) transcriptional repressors [69][70][71]. JA gene regulation is modulated by JA-hormone binding to COI1 and the degradation of JAZ repressors, freeing repressed transcription factors to upregulate JA genes [67].…”

Section: How Do Pp-insps Function In Plants?mentioning

confidence: 99%

Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?

Freed

Adepoju

Gillaspy

2020

Plants

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Inositol pyrophosphates (PP-InsPs) are an emerging class of “high-energy” intracellular signaling molecules, containing one or two diphosphate groups attached to an inositol ring, that are connected with phosphate sensing, jasmonate signaling, and inositol hexakisphosphate (InsP6) storage in plants. While information regarding this new class of signaling molecules in plants is scarce, the enzymes responsible for their synthesis have recently been elucidated. This review focuses on InsP6 synthesis and its conversion into PP-InsPs, containing seven and eight phosphate groups (InsP7 and InsP8). These steps involve two types of enzymes: the ITPKs that phosphorylate InsP6 to InsP7, and the PPIP5Ks that phosphorylate InsP7 to InsP8. This review also considers the potential roles of PP-InsPs in plant hormone and inorganic phosphate (Pi) signaling, along with an emerging role in bioenergetic homeostasis. PP-InsP synthesis and signaling are important for plant breeders to consider when developing strategies that reduce InsP6 in plants, as this will likely also reduce PP-InsPs. Thus, this review is primarily intended to bridge the gap between the basic science aspects of PP-InsP synthesis/signaling and breeding/engineering strategies to fortify foods by reducing InsP6.

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“…7 ). In this MD simulation, we used inositol octakisphosphate (InsP 8 ) instead of inositol pentakisphosphate (InsP 5 ) because previous reports showed that InsP 8 also formed stable complex with COI1- 2 -JAZ instead of phosphates (PO 4 ) 37 , 38 . In planta At JAZ9-selectivity of 2e was tested by using a GUS reporter assay using A. thaliana reporter lines, 35S: JAZ1-GUS , 35S: JAZ9-GUS , 35S: JAZ10-GUS , and 35S: JAZ12-GUS (Fig.…”

Section: Resultsmentioning

confidence: 99%

Subtype-selective agonists of plant hormone co-receptor COI1-JAZs identified from the stereoisomers of coronatine

et al. 2023

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Severe genetic redundancy is particularly clear in gene families encoding plant hormone receptors, each subtype sharing redundant and specific functions. Genetic redundancy of receptor family members represents a major challenge for the functional dissection of each receptor subtype. A paradigmatic example is the perception of the hormone (+)-7-iso-jasmonoyl-L-isoleucine, perceived by several COI1-JAZ complexes; the specific role of each receptor subtype still remains elusive. Subtype-selective agonists of the receptor are valuable tools for analyzing the responses regulated by individual receptor subtypes. We constructed a stereoisomer library consisting of all stereochemical isomers of coronatine (COR), a mimic of the plant hormone (+)-7-iso-jasmonoyl-L-isoleucine, to identify subtype-selective agonists for COI1-JAZ co-receptors in Arabidopsis thaliana and Solanum lycopersicum. An agonist selective for the Arabidopsis COI1-JAZ9 co-receptor efficiently revealed that JAZ9 is not involved in most of the gene downregulation caused by COR, and the degradation of JAZ9-induced defense without inhibiting growth.

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The Binding Mechanism Between Inositol Phosphate (InsP) and the Jasmonate Receptor Complex: A Computational Study

Cited by 10 publications

References 55 publications

Genome-wide identification and interactome analysis of members of two-component system in Banana

Genome-wide identification and interactome analysis of members of two-component system in Banana

Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?

Subtype-selective agonists of plant hormone co-receptor COI1-JAZs identified from the stereoisomers of coronatine

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