The bioactivity of plant extracts against representative bacterial pathogens of the lower respiratory tract

Abstract

BackgroundLower respiratory tract infections are a major cause of illness and death. Such infections are common in intensive care units (ICU) and their lethality persists despite advances in diagnosis, treatment and prevention. In Mexico, some plants are used in traditional medicine to treat respiratory diseases or ailments such as cough, bronchitis, tuberculosis and other infections. Medical knowledge derived from traditional societies has motivated searches for new bioactive molecules derived from plants that show potent activity against bacterial pathogens. Therefore, the aim of this study was to evaluate the effect of hexanic, chloroformic (CLO), methanolic (MET) and aqueous extracts from various plants used in Mexican traditional medicine on various microorganisms associated with respiratory disease.Methodsthirty-five extracts prepared from nine plants used in Mexican traditional medicine for the treatment of respiratory infections were evaluated against 15 control bacterial species and clinical isolates.ResultsBoth chloroformic (CLO) and methanolic (MET) extracts of Larrea tridentata were active against Methicillin-resistant S. aureus, B. subtilis and L. monocytogenes. A MET extract of L. tridentata was also active against S. aureus, S. pneumoniae, S. maltophilia, E. faecalis and H. influenzae and the CLO extract was active against A. baumannii. An Aqueous extract of M. acumitata and a MET extract of N. officinale were active against S. pneumoniae. CLO and MET extracts of L. tridentata were active against clinical isolates of S. aureus, S. pneumoniae and E. faecalis.ConclusionOverall, our results support the potential use of L. tridentata as a source of antibacterial compounds.

Antibacterial and Antimycobacterial Lignans and Flavonoids from Larrea tridentata

“…Antibacterial and antimycobacterial assays were determined as previously described in the literature (Camacho‐Corona et al ., ; Bocanegra‐García et al ., ). An institutional ethical committee has approved this work.…”

“…In previous studies we carried out a screening of 36 extracts obtained from nine plants used in Mexican traditional medicine to treat respiratory infections including tuberculosis. The results of those studies showed that the chloroformic extract of Larrea tridentata had activity against methicillin resistant (MR) Staphylococcus aureus BAA‐44 (MIC 250 µg/mL), Bacillus subtilis (MIC 62.25 µg/mL), Lysteria monocytogenes (MIC 125 µg/mL), Acinetobacter baumannii (MIC 125 µg/mL) (Bocanegra‐García et al ., ) and a sensitive (MIC 200 µg/mL) and four monoresistant strains of M. tuberculosis H37Rv (MIC 100–200 µg/mL) (Camacho‐Corona et al ., ). Thus, we carried out the isolation and characterization of active compounds from L. tridentata .…”

Efficiency of Egyptian Plant Extracts on the Antibiotic Susceptibleand Resistant Pathogenic bacterial Isolates

“…Although, new generations of antibiotics were produced by pharmacological companies,the drug resistance has been increased (Tenover, 2006 andChovanová et al, 2013). This situation has forced the scientists attention towards natural and herbal products to develop better quality drugs with improved antibacterial activities (Bako et al,2005;Sibanda & Okoh, 2007;Bocanegra-Garcia et al, 2009 andSaranraj, 2014 ). Djeussi et al (2013), provided useful baseline information for the potential use of some edible plants in the fight against both sensitive and multidrug-resistant (MDR) phenotypes.…”

Estimation of cytotoxic potency by brine shrimp lethality bioassay application of Clerodendrum infortunatum Linn.

“…The antimicrobial potential of different medicinal plants is being extensively studied all over the world, but only a few studies have been carried out in a systematic manner [2]. Medical knowledge derived from traditional societies has motivated searches for new bioactive molecules derived from plants that show potent activity against bacterial pathogens [3]. Nowadays, some researchers are providing laboratory trials to justify for the use of the plants in folk medicine to treat various infectious diseases [4].…”