The biochemical and clinical consequences of lead poisoning

Al‐Saleh, Iman

doi:10.1002/med.2610140404

Cited by 32 publications

(9 citation statements)

References 687 publications

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“…Lead has been known to be an environmental pollutant and its toxicity has also been associated with health hazards [8]. The liver acts as chief player in detoxification process and is one of the target organs affected by lead toxicity owing to its storage in the liver.…”

Section: Discussionmentioning

confidence: 99%

“…Lead induced oxidative damage in the kidney as evidenced by enhancement of lipid peroxidation [6, 7]. Lead is a highly poisonous environmental pollutant and is known to affect organs like liver, kidney, blood, and central nervous system of mammals [8, 9]. Several reports have indicated that lead can cause neurological, hematological, gastrointestinal, reproductive, circulatory, and immunological pathologies [10, 11].…”

Section: Introductionmentioning

confidence: 99%

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Protective Role of Omega-3 Polyunsaturated Fatty Acid against Lead Acetate-Induced Toxicity in Liver and Kidney of Female Rats

Abdou

Hassan

2014

BioMed Research International

113

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The present study was conducted to investigate the protective role of Omega-3 polyunsaturated fatty acids against lead acetate-induced toxicity in liver and kidney of female rats. Animals were divided into four equal groups; group 1 served as control while groups 2 and 3 were treated orally with Omega-3 fatty acids at doses of 125 and 260 mg/kg body weight, respectively, for 10 days. These groups were also injected with lead acetate (25 mg/kg body weight) during the last 5 days. Group 4 was treated only with lead acetate for 5 days and served as positive control group. Lead acetate increased oxidative stress through an elevation in MDA associated with depletion in antioxidant enzymes activities in the tissues. Moreover, the elevation of serum enzymes activities (ALT, AST, ALP, and LDH) and the levels of urea and creatinine were estimated but total proteins were decreased. Also, lead acetate-treatment induced hyperlipidemia via increasing of lipid profiles associated with decline in HDL-c level. Significant changes of Hb, PCV, RBCs, PLT, and WBCs in group 4 were recorded. The biochemical alterations of lead acetate were confirmed by histopathological changes and DNA damage. The administration of Omega-3 provided significant protection against lead acetate toxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective Role of Omega-3 Polyunsaturated Fatty Acid against Lead Acetate-Induced Toxicity in Liver and Kidney of Female Rats

Abdou

Hassan

2014

BioMed Research International

113

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“…It has been proposed that the toxicity of lead may be due, at least in part, to the inhibition of the sulfhydryl-containing enzyme aminolevulinate dehydratase (ALA-D). ALA-D activity in erythrocytes is currently the most sensitive indicator of human exposure to lead (Al-Saleh 1994).…”

Section: Resultsmentioning

confidence: 99%

Disposition of lead (Pb) in blood of rats following oral exposure to lipstick

Hashemi‐Moghaddam

Shiravi

Shadab-Shamsabad

et al. 2013

E3S Web of Conferences

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Abstract. Information about the health risks that might be associated with lipstick consumption effects is scarce in the literature. The present work investigated the bioaccumulation of lead (Pb) in blood of rats originated from lipstick sample. First, Lead contents were determined in 12 different brands of lipsticks. Lead was detected in all the studied samples. The average lead content in 14 lipsticks samples was 12.2 PPM wet wt. Then, one brand was selected for feeding to the rats and amount of oral exposing in the three doses was calculated. Sixty rats were used for the experiment. Animals were divided into 4 groups of 15 animals each. While 1group served as control group, the remaining 3 groups were exposed to lipstick through oral gavage for 12 weeks. Results show that, exposure to the lipstick cause significantly disposition of lead in the blood of rats.

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“…The cognitive and motor deficits in children have been associated with low levels of lead exposure (Al-Saleh, 1994;Bressler et al, 1999). Lead affects the bones and teeth, the kidneys, the nervous, cardiovascular, immune and reproductive systems (Freitag, 2007).…”

Section: Introductionmentioning

confidence: 99%

Chemical speciation of binary complexes of Pb(II), Cd(II) and Hg(II) with L-glutamic acid in dioxan-water mixtures

Naik

Raju

Kumar

et al. 2012

Chemical Speciation & Bioavailability

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Binary complexes of L-glutamic acid with toxic metal ions such as Pb(II), Cd(II) and Hg(II) in 0.0-60.0% v/v 1,4 dioxan-water media at 303.0 K and an ionic strength of 0.16 mol dm -3 of sodium nitrate has been studied pH-metrically. The active forms of ligand are LH 3 , LH 2 and LH. The best fit chemical models are chosen based on statistical parameters like crystallographic R-factor, χ 2 , skewness and kurtosis. The predominant species detected are ML 2 H 4, ML 2 H 3, ML 2 H 2, ML 2 and ML. Models containing different numbers of species were refined by using the computer program MINIQUAD75. The trend in variation of complex stability constants with changes in the dielectric constant of the medium is explained on the basis of electrostatic and non-electrostatic forces. The species distribution with pH at different compositions of dioxan-water mixture and plausible equilibria for the formation of species are also presented.

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The biochemical and clinical consequences of lead poisoning

Cited by 32 publications

References 687 publications

Protective Role of Omega-3 Polyunsaturated Fatty Acid against Lead Acetate-Induced Toxicity in Liver and Kidney of Female Rats

Protective Role of Omega-3 Polyunsaturated Fatty Acid against Lead Acetate-Induced Toxicity in Liver and Kidney of Female Rats

Disposition of lead (Pb) in blood of rats following oral exposure to lipstick

Chemical speciation of binary complexes of Pb(II), Cd(II) and Hg(II) with L-glutamic acid in dioxan-water mixtures

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