The biochemistry of organo-tin compounds. Diethyltin dichloride and triethyltin sulphate

Aldridge, W. N.; Cremer, Jill E.

doi:10.1042/bj0610406

Cited by 176 publications

(78 citation statements)

References 28 publications

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“…Already in the first investigation on the biochemical effects of organotin compounds, diethyltin dichloride and triethyltin sulphate were recognized as powerful metabolic inhibitors, each with a different mode of acton (Aldridge and Cremer, 1955).…”

Section: Effects On Mitochondrial Respirationmentioning

confidence: 99%

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Biological activity of organotin compounds—An overview

Snoeij

Penninks

Seinen

1987

Environmental Research

348

131

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As a consequence of the rapid expansion of the uses and applications of the organotin compounds, the concern about their environmental and health effects is increasing. The main subject of this overview is the current understanding of the mammalian toxicity of the organotin compounds. Four different types of target organ toxicity, namely neurotoxicity, hepatotoxicity, immunotoxicity, and cutaneous toxicity, are discussed in more detail. The effects of the organotin compounds on the mitochondfial and cellular level are summarized and discussed in relation to the mode of action of these compounds on the central nervous system, the liver and bile duct, the immune system, and the skin. © 1987 Academic Press, Inc. ORGANOTIN COMPOUNDS: APPLICATIONS AND TOXICITY Organotin CompoundsTin can be present as an element in a wide variety of both inorganic and organometallic compounds. Organometallic tin compounds or organotins are characterized by the presence of at least one covalent carbon-tin bond. Although tin may exist either in the Sn 2+ or in the Sn 4+ oxidation state, almost all organotins have a tetravalent structure. Depending on the number of organic moieties, the organotin compounds are classified as mono-, di-, tri-, and tetraorganotins. In compounds of industrial importance, methyl, butyl, octyl, and phenyl groups form the organic substituents, while the anion is usually chloride, fluoride, oxide, hydroxide, carboxylate, or thiolate. All alkyltin compounds refered to in this article contain unbranched saturated hydrocarbon side chains (n-alkyltins).

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Section: Effects On Mitochondrial Respirationmentioning

confidence: 99%

“…The effects of the triorganotin compounds on mitochondria have been studied intensively (Aldridge and Cremer, 1955;Aldridge, 1958Aldridge, , 1976Aldridge and Street, 1964;Selwyn et al, 1970;Selwyn, 1976). Three different types of interaction with the mitochondrial respiration could be distinguished.…”

Section: Effects On Mitochondrial Respirationmentioning

confidence: 99%

Biological activity of organotin compounds—An overview

Snoeij

Penninks

Seinen

1987

Environmental Research

348

131

View full text Add to dashboard Cite

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“…The properties of trialkyltin compounds to interfere with mitochondrial energy production have been intensively studied [6][7][8][9]. Three different mechanisms for disturbing mitochondrial ATP synthesis were distinguished: (i) by mediating the exchange of halide for hydroxyl ions across the mitochondrial membranes; (ii) by binding to a component of the mitochondrial Mg2+-ATPase to produce an oligomycin-like effect; and (iii) by causing gross mitochondrial swelling.…”

Section: Introductionmentioning

confidence: 99%

Effects of tri-n-butyltin chloride on energy metabolism, macromolecular synthesis, precursor uptake and cyclic AMP production in isolated rat thymocytes

Snoeij

Punt

Penninks

et al. 1986

Biochimica et Biophysica Acta (BBA) - Bioenergetics

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The inhibitor of oxidative phosphorylation tri-n-butyltin chloride (TBTC) causes membrane damage and disintegration of isolated rat thymocytes at concentrations higher than 1 ixM. From a concentration of 0.1 I~M, TBTC disturbs energy metabolism as indicated by an increase in methylglucose uptake, glucose consumption and lactate production and by a decrease in cellular ATP levels. Over the same TBTC concentration range, the incorporation of DNA, RNA and protein precursors are markedly reduced. Moreover the production of cyclic AMP upon stimulation of the cells with prostaglandin E 1 is effectively inhibited. These effects cannot be explained by an inhibition of nucleoside kinase activity, amino acid uptake or adenylate cyclase activity. The effects of TBTC on macromolecular synthesis and cyclic AMP production are possibly due to a disturbance of the cellular energy state.

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“…Diethyltin dichloride has been shown to decrease oxygen uptake in rat brain in vitro by binding to sulfhydral groups in a -keto acid oxidases with the resultant inhibition of these enzymes (Aldridge and Cremer, 1955).…”

Section: Histopathologymentioning

confidence: 99%

“…Trialkyltin compounds have been shown to produce interstitial edema of the white matter of the brain in rats (Magee et al, 1957) and inhibit oxidative phosphorylation in vitro (Aldridge and Cremer, 1955;Aldridge and Street, 1964. Inhibition of muscular contractility in vitro associated with disruption of mitochondria, disorganization of muscle fibers and depletion of neuromicrotubules has also been observed (Tan and Ng, 1977).…”

mentioning

confidence: 99%