The Biological Activities of Hypericum Perforatuml

Ökmen, Gülten; Balpinar, Neslihan

doi:10.21010/ajtcam.v14i1.23

Cited by 25 publications

(12 citation statements)

References 26 publications

(24 reference statements)

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“…Additionally, as expected, Hypericum extracts were quite potent against S. aureus , with MICs on a multidrug-resistant (MDR) strain of 4 mg/L for H. brasiliense [ 87 ]. In some cases though, the MeOH extract from H. perforatum could give MICs against S. aureus and staphylococci isolated from cow mastitis as high as 813 mg/L [ 88 ]. The best activity against Gram-negative bacteria that we know of was the MIC of 7.8 mg/L against Helicobacter pylori that belonged to a fraction from the MeOH extract of H. perforatum [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

Outstanding Antibacterial Activity of Hypericum rochelii—Comparison of the Antimicrobial Effects of Extracts and Fractions from Four Hypericum Species Growing in Bulgaria with a Focus on Prenylated Phloroglucinols

Ilieva

Marinov

Trayanov

et al. 2023

Life

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Microbial infections are by no means a health problem from a past era due to the increasing antimicrobial resistance of infectious strains. Medicine is in constant need of new drugs and, recently, plant products have had a deserved renaissance and garnered scientific recognition. The aim of this work was to assess the antimicrobial activity of ten active ingredients from four Hypericum species growing in Bulgaria, as well as to obtain preliminary data on the phytochemical composition of the most promising samples. Extracts and fractions from H. rochelii Griseb. ex Schenk, H. hirsutum L., H. barbatum Jacq. and H. rumeliacum Boiss. obtained with conventional or supercritical CO2 extraction were tested on a panel of pathogenic microorganisms using broth microdilution, agar plates, dehydrogenase activity and biofilm assays. The panel of samples showed from weak to extraordinary antibacterial effects. Three of them (from H. rochelii and H. hirsutum) had minimum inhibitory concentrations as low as 0.625–78 mg/L and minimum bactericidal concentrations of 19.5–625 mg/L against Staphylococcus aureus and other Gram-positive bacteria. These values placed these samples among the best antibacterial extracts from the Hypericum genus. Some of the agents also demonstrated very high antibiofilm activity against methicillin-resistant S. aureus. Ultra-high-performance liquid chromatography–high-resolution mass spectrometry revealed the three most potent samples as rich sources of biologically active phloroglucinols. They were shown to be good drug or nutraceutical candidates, presumably without some of the side effects of conventional antibiotics.

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Section: Discussionmentioning

confidence: 99%

Outstanding Antibacterial Activity of Hypericum rochelii—Comparison of the Antimicrobial Effects of Extracts and Fractions from Four Hypericum Species Growing in Bulgaria with a Focus on Prenylated Phloroglucinols

Ilieva

Marinov

Trayanov

et al. 2023

Life

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“…St. John's Wort is a well-known mood stabilizer and therapy for moderate depression. 80 However; it may be especially beneficial to women going through menopause. St. John's Wort has been shown to enhance mood and calm mood fluctuations associated with menopause, especially when coupled with black cohosh.…”

Section: Hypericum Perforatum (St John's Wort)mentioning

confidence: 99%

Promising Herbs as Alternatives for Women with Symptoms of Menopause: A Review

Manipriya¹,

Mallika²,

Dixit³

et al. 2021

JDVAT

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Hot flashes, sleep issues, bipolar disorder, decreased libido, weight gain, and impairments in cognitive performance are all common symptoms of menopause. Herbs and alternative therapies are often of great value to people in the management and treatment of the signs and complications of menopause, due to the adverse effects of hormone therapy. The practices and effects of medicinal plants used in the management of menopausal symptoms are thoroughly reviewed in this article. Clinical investigations have recently demonstrated the efficacy of using many plants and herbs to alleviate menopausal symptoms. Some herbs' traditional uses also have been noted. Medicinal herbs have the potential to exhibit an important role in the treatment of menopausal symptoms; however, further research is needed to back up their efficacy in this domain.

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“…Предполагается, что бактериостатическая И ГЕНИТАЛЬНАЯ ХИРУРГИЯ ТОМ 18 / VOL. 18 2 0 1 7 ANDROLOGY AND GENITAL SURGERY О р и г и н а л ь н а я с т а т ь я активность препарата обусловлена комбинацией эффектов, которые имеют входящие в него растительные компоненты [21][22][23][24][25].…”

Section: материалы и методыunclassified

Antimicrobial Activity of Prostanorm® Against the Uropathogens Isolated From Patients With Chronic Prostatitis

Русанова¹,

Василенко²,

Гурьев³

et al. 2017

Androl. genit. hir.

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Лекарственный препарат ПростаНорм ® (таблетки 0,2 г № 10; экстракт жидкий для приема внутрь 50 и 100 мл), представляющий собой комплексный экстракт (сухой или жидкий), получаемый из смеси лекарственного растительного сырья (травы зверобоя и золотарника канадского, корни солодки, корневище с корнями эхинацеи пурпурной), почти 20 лет с успехом применяется для лечения хронического простатита (ХП), и прежде всего абактериального, бесплодия (патозооспермии) вследствие ХП (в комплексной терапии) и для нормализации мочеиспускания. Проведенные ранее исследования свидетельствовали об антимикробных свойствах ПростаНорма ® , что в сочетании с его другими известными свойствами (противовоспалительным, анальгезирующим, улучшающим микроциркуляцию тканей предстательной железы и показатели эякулята) дает предпосылки к применению препарата у больных хроническим бактериальным простатитом (ХБП). Цель настоящего исследования-оценить в условиях опытов in vitro бактериостатические свойства лекарственного препарата ПростаНорм ® в отношении уропатогенов, выделенных из клинического материала у пациентов с уроинфекцией (преимущественно с ХП).

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The Biological Activities of Hypericum Perforatuml

Cited by 25 publications

References 26 publications

Outstanding Antibacterial Activity of Hypericum rochelii—Comparison of the Antimicrobial Effects of Extracts and Fractions from Four Hypericum Species Growing in Bulgaria with a Focus on Prenylated Phloroglucinols

Outstanding Antibacterial Activity of Hypericum rochelii—Comparison of the Antimicrobial Effects of Extracts and Fractions from Four Hypericum Species Growing in Bulgaria with a Focus on Prenylated Phloroglucinols

Promising Herbs as Alternatives for Women with Symptoms of Menopause: A Review

Antimicrobial Activity of Prostanorm® Against the Uropathogens Isolated From Patients With Chronic Prostatitis

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