The blood changes in anaphylactic shock in the dog

Dean, H. R.; Webb, Robyn

doi:10.1002/path.1700270107

Cited by 21 publications

(6 citation statements)

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“…The leukopenia that followed the platelet antigen-antibody reaction has been shown to be characteristic of many types of in vivo immune reactions (16,21,22). In the four patients studied, the rate and magnitude of the reduction in the leukocyte count was roughly proportional to the rate at which Cr51-labeled platelets were destroyed, suggesting that leukocytes were directly affected by sensitized platelets.…”

Section: Resultsmentioning

confidence: 99%

Platelet Sequestration in Man. II. Immunological and Clinical Studies*

Aster¹,

Jandl²

1964

J. Clin. Invest.

136

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The mechanisms of platelet destruction and their sites of sequestration in disease states are poorly understood. Although recent studies have emphasized the importance of platelet isoantibodies in certain clinical situations (1-3), little is known of the effects of antibodies on platelets in vivo. In conditions such as idiopathic thrombocytopenic purpura, there is debate as to whether immune mechanisms are involved, and sites of platelet sequestration are unknown.The availability of a method for labeling platelets with Cr5' that allows most of the transfused platelets to remain viable and reduces the initial deposition of nonviable platelets in the liver and spleen (4) permits study of some of these aspects of platelet pathophysiology. We investigated the survival and sites of sequestration of platelets exposed to isoantibodies in vivo. Included in this paper are observations of pyrogenic reactions after immune platelet destruction. Studies in patients with idiopathic thrombocytopenic purpura and other platelet disorders are also described. MethodsPreparation and transfusion of Cr51-!abeled "citrate platelets" and determination of the percentage of platelet survival were as described in the preceding report (4). In "extracting" Cr51-labeled platelets from blood samples taken from thrombocytopenic persons, nonradioactive platelets were added to the platelet-rich plasma to facilitate recovery of platelet Cr51. For isologous transfusions, only platelets from donors compatible with the recipients' ABO and Rh blood types were used.Methods of scintillation scanning over organs to evaluate sites of platelet sequestration have been described

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Section: Resultsmentioning

confidence: 99%

Platelet Sequestration in Man. II. Immunological and Clinical Studies*

Aster¹,

Jandl²

1964

J. Clin. Invest.

136

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“…Actual red cell lysis by the immune mechanism appears to be required for the febrile response as well as for the leukopenic response. The reinjection of soluble bacterial (23) and nonbacterial (53) antigens has been shown to produce fever as well as leukopenia (20)(21)(22)(23). Therefore the association of both fever and leukopenia with actual lysis by immune mechanisms suggests that both reactions are caused by the release into the blood stream of antigen-antibody complexes from hemolyzing red cells.…”

Section: Leukopenia During Immune Hemolysismentioning

confidence: 99%

“…Indeed it is well established that the injection into sensitized animals of noncellular antigens provokes leukopenia (20)(21)(22)(23) and often thrombocytopenia (24) much as does the injection of bacterial extracts ("pyrogens" or "endotoxins") into normal animals, including man (25)(26)(27)(28)(29)(30).…”

Section: Leukopenia During Immune Hemolysismentioning

confidence: 99%

The Destruction of Red Cells by Antibodies in Man. II. Pyrogenic, Leukocytic and Dermal Responses to Immune Hemolysis1

Jandl¹,

Tomlinson²

1958

J. Clin. Invest.

105

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“…Finally, the liberation of histamine (or H-substance) will not suffice as an explanation of all symptoms, and it is assumed that other humoral intermediaries (heparine, acetylcholine) are also active.In anaphylactic shock (in animals) there occurs a sudden change in the permeability of the capillaries and in the tone of the smooth muscles in various organs; this rapidly involves changes in the blood pressure, respiration and the chemical and cytological composition of the blood.For example, there may be a greater or smaller fall in the blood pressure (7), haemoconcentration, together with a decrease in the number of leucocytes and thrombocytes (5,6,8,9, 12,20, 21,22,28,29), and the coagulation time is prolonged (up to It should be observed, however, that in anaphylactic shock the symptoms may vary considerably from one kind of animal to another, just as in man the allergic shock has no uniform symptomatology.…”

mentioning

confidence: 99%

“…For example, there may be a greater or smaller fall in the blood pressure (7), haemoconcentration, together with a decrease in the number of leucocytes and thrombocytes (5,6,8,9, 12,20, 21,22,28,29), and the coagulation time is prolonged (up to…”

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confidence: 99%

Blood Examinations in Hay Fever Patients During Acute Allergic Shock

Castberg¹,

Schwartz²

1948

Allergy

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Allergic shock in tnan comes unexpectedly in most cases, or at any rate under conditions prohibiting exact examination of the composition of the blood while the shock lasts; as a result, our knowledge of any changes there may be in the state of the blood during allergic shock rests upon a relatively slender foundation.In animals, anaphylactic shock is generally considered to be analogous to allergic shock in man; the pathogenesis is assumed to be the same in both reactions: an antigen-antibody reaction liberates a histamine-like substance which thereupon induces the local and general symptoms (4, 6). It should be observed, however, that in anaphylactic shock the symptoms may vary considerably from one kind of animal to another, just as in man the allergic shock has no uniform symptomatology. Finally, the liberation of histamine (or H-substance) will not suffice as an explanation of all symptoms, and it is assumed that other humoral intermediaries (heparine, acetylcholine) are also active.In anaphylactic shock (in animals) there occurs a sudden change in the permeability of the capillaries and in the tone of the smooth muscles in various organs; this rapidly involves changes in the blood pressure, respiration and the chemical and cytological composition of the blood.For example, there may be a greater or smaller fall in the blood pressure (7), haemoconcentration, together with a decrease in the number of leucocytes and thrombocytes (5,6,8,9, 12,20, 21,22,28,29), and the coagulation time is prolonged (up to

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The blood changes in anaphylactic shock in the dog

Cited by 21 publications

References 0 publications

Platelet Sequestration in Man. II. Immunological and Clinical Studies*

Platelet Sequestration in Man. II. Immunological and Clinical Studies*

The Destruction of Red Cells by Antibodies in Man. II. Pyrogenic, Leukocytic and Dermal Responses to Immune Hemolysis1

Blood Examinations in Hay Fever Patients During Acute Allergic Shock

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