The brain and gastrointestinal cholecystokinin receptor family; structure and functional expression

Expression of peptide receptors in human endocrine tumours of the pancreas.

“…26 Receptors for cholecystokinin can be classified into two subtypes, cholecystokinin-A and cholecystokinin-B. A recent study using in situ hybridisation showed that the gastrin receptor is identical to the 27 cholecystokinin-B receptor. The present study is the first to show cholecystokinin-B (gastrin) receptors in human VIPomas with high affinity and binding capacity.…”

The peripheral cholecystokinin receptors

“…4) [177]. In addition, when the cDNA encoding pancreatic CCK-A receptor was expressed in COS-7 cells, CCK binding revealed two affinity classes of sites, as in pancreatic acini [178]. The general mechanism by which the two affinity states of a receptor are regulated by guanine-nucleotide-binding regulatory protein(s) and the role of this process in receptor signalling has been clarified for other receptors [179].…”

Differential Expression of Gastrin, Cholecystokinin-A and Cholecystokinin-B Receptor mRNA in Human Pancreatic Cancer Cell Lines

“…CCK-AR in the pancreas control enzyme secretion and growth, while CCK-BR in the gastric gland control gastric acid secretion and growth of the acid-producing mucosa (6)(7)(8)(9). CCK-AR is highly selective with a higher af nity for sulphated CCK-8 than gastrin, whereas CCK-BR bind C-terminally amidated gastrin-17 and related peptides with the same af nity as CCK-8, thereby inducing signal transduction (1)(2)(3)(4). Both types of receptor are known to signal by coupling to G proteins and stimulating phospholipas e C, tyrosine phosphorylation , mitogen-activated kinases and jun kinases (reviewed in 10) and to have growth-stimulating effects.…”

“…T wo types of receptor for gastrin and cholecystokinin (CCK) have been cloned and identi ed (1)(2)(3)(4). CCK-A receptors (CCK-AR) are expressed in the pancreas, the gallbladder and parts of the brain, while CCK-B receptors (CCK-BR) occur in gastric glands and in most of the brain (1)(2)(3)(4)(5).…”

“…CCK-A receptors (CCK-AR) are expressed in the pancreas, the gallbladder and parts of the brain, while CCK-B receptors (CCK-BR) occur in gastric glands and in most of the brain (1)(2)(3)(4)(5). CCK-AR in the pancreas control enzyme secretion and growth, while CCK-BR in the gastric gland control gastric acid secretion and growth of the acid-producing mucosa (6)(7)(8)(9).…”