The Brain laryngeal mask

Bailie, R. W.; Barnett, M. J.; Fraser, John F.

doi:10.1111/j.1365-2044.1991.tb09543.x

Cited by 19 publications

(1 citation statement)

References 6 publications

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“…The ability of polymers to selectively recognize and bind molecular and macromolecular species in gastrointestinal fluids offers the possibility to discover and develop a new class of therapeutic agents that can selectively sequester and remove detrimental species from the GI tract. Furthermore, the synthetic methods developed to incorporate multiple copies of various ligands along the polymer chain can lead to "multivalent" interaction with complementary targets with extremely high binding constants compared to what can be achieved with low molecular weight drugs (7).…”

Section: Introductionmentioning

confidence: 99%

(Bio)polymeric Hydrogels as Therapeutic Agents

Dhal

Gianolio

Miller

2011

Journal of Macromolecular Science, Part A

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Hydrogels derived from both natural and synthetic polymers have gained significant scientific attention in recent years for their potential use as biomedical materials to treat human diseases. While a great deal of research efforts have been directed towards investigating polymeric hydrogels as matrices for drug delivery systems, examples of such hydrogels exhibiting intrinsic therapeutic properties are relatively less common. Characteristics of synthetic and natural polymers such as high molecular weight, diverse molecular architecture, chemical compositions, and modulated molecular weight distribution are unique to polymers. These characteristics of polymers can be utilized to discover a new generation of drugs and medical devices. For example, polymeric hydrogels can be restricted to the gastrointestinal tract, where they can selectively recognize, bind, and remove the targeted disease-causing substances from the body without causing any systemic toxicity that are associated with traditional small molecule drugs. Similarly hydrogels can be implanted at specific locations (such as knee and abdomen) to impart localized therapeutic benefits. The present article provides an overview of certain recent developments in the design and synthesis of functional hydrogels that have led to several polymer derived drugs and biomedical devices. Some of these examples include FDA-approved marketed products.

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Section: Introductionmentioning

confidence: 99%

(Bio)polymeric Hydrogels as Therapeutic Agents

Dhal

Gianolio

Miller

2011

Journal of Macromolecular Science, Part A

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The laryngeal mask airway: its features, effects and role

1994

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The laryngeal mask airway was designed as a new concept in airway management and has been gaining a firm position in anaesthetic practice. Numerous articles and letters about the device have been published in the last decade, but few large controlled trials have been performed. Despite widespread use, the definitive role of the laryngeal mask has yet to be established. In some situations, such as after failed tracheal intubation or in anaesthesia for patients undergoing laparoscopic or oral surgery, its use is controversial. There are a number of unresolved issues, for example the effect of the laryngeal mask on regurgitation and whether or not cricoid pressure prevents placement of the mask. We review the techniques of insertion, details of misplacement, and complications associated with the use of the laryngeal mask. We discuss the features and physiological effects of the device, including the changes in intra-cuff pressure during anaesthesia and effects on blood pressure, heart rate and intra-ocular pressure. We then attempt to clarify the role of the laryngeal mask in airway management during anaesthesia, based on the current knowledge, by discussing the advantages and disadvantages as well as the indications and contraindications of its use. Lastly we describe the use of the laryngeal mask in circumstances other than airway maintenance during anaesthesia: fibreoptic bronchoscopy, tracheal intubation through the mask and its use in cardiopulmonary resuscitation.

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