The Brain Research Africa Initiative (BRAIN)

Njamnshi, Alfred K.; Ahidjo, Nene; Annoni, Jean Marie; Chabwine, Joëlle Nsimire; Hachinski, Vladimir; Ngarka, Leonard; Njamnshi, Alfred Kongnyu; Njamnshi, Wepnyu Yembe; Perrig, Stephen; Sztajzel, Roman

doi:10.1016/s1474-4422(23)00164-3

Cited by 5 publications

(4 citation statements)

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“…This approach is vital to advocate for action, policy development, and support in the region regarding the importance and urgency of the diagnosis and management of AD and related dementias, as was recently declared in Nairobi during the LMIC conference on dementia [ 36 ]. Examples of networks and partnerships established by the Africa Dementia Consortium, Africa Biofluid Brain Biobank (A4B), and the Brain Research Africa Initiative (BRAIN) can be very useful in this regard [ 99 ].…”

Section: Requirements Before Implementing Circulating Biomarkers In L...mentioning

confidence: 99%

Circulating Biomarkers for Alzheimer’s Disease: Unlocking the Diagnostic Potential in Low- and Middle-Income Countries, Focusing on Africa

Nwamekang Belinga,

Espourteille,

Wepnyu Njamnshi

et al. 2024

Neurodegener Dis

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Background: Alzheimer's disease (AD) is emerging as a significant public health challenge in Africa, with predictions indicating a tripling in incidence by 2050. The diagnosis of AD on the African continent is notably difficult, leading to late detection that severely limits treatment options and significantly impacts the quality of life for patients and their families. Summary: This review focuses on the potential of high-sensitivity specific blood biomarkers as promising tools for improving AD diagnosis and management globally, particularly in Africa. These advances are particularly pertinent in the continent, where access to medical and technical resources is often limited. Key Messages: Identifying precise, sensitive, and specific blood biomarkers could contribute to the biological characterization and management of Alzheimer's disease in Africa. Such advances promise to improve patient care and pave the way for new regional opportunities in pharmaceutical research and drug trials on the continent for Alzheimer's disease.

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Section: Requirements Before Implementing Circulating Biomarkers In L...mentioning

confidence: 99%

Circulating Biomarkers for Alzheimer’s Disease: Unlocking the Diagnostic Potential in Low- and Middle-Income Countries, Focusing on Africa

Nwamekang Belinga,

Espourteille,

Wepnyu Njamnshi

et al. 2024

Neurodegener Dis

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“…The African Partnership for Chronic Disease Research (APCDR) is an initiative exploring Africa’s determinants and burdens of chronic disease [ 8 ]. Although its scope is not exclusively limited to brain research, the APCDR’s focus encompasses conditions that impact the brain, such as stroke, epilepsy, and neurodegenerative diseases.…”

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confidence: 99%

“…Although its scope is not exclusively limited to brain research, the APCDR’s focus encompasses conditions that impact the brain, such as stroke, epilepsy, and neurodegenerative diseases. The Institute of Cognitive Neuroscience at the University of Nigeria is dedicated to studying cognitive neuroscience, with a particular emphasis on investigating the neural mechanisms underlying information processing and cognitive functions unique to African populations [ 8 ]. The researchers investigate various subjects, including but not limited to language processing, perception, attention, and memory.…”

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confidence: 99%

“…The researchers investigate various subjects, including but not limited to language processing, perception, attention, and memory. The H3Africa Initiative is a collaborative endeavor that involves several African nations and focuses on human heredity and health in Africa [ 8 ]. Although not exclusively centered on neuroscience, the objective is to employ genomics to comprehend the genetic foundation of illnesses that are widespread in Africa, such as neurological disorders, and to establish customized healthcare strategies for African communities.…”

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confidence: 99%

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Strengthening Brain Research in Africa

Aborode,

Idowu,

Tundealao

et al. 2023

Journal of Alzheimer's Disease Reports

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This paper explores the emerging field of neuroscience in Africa, considering the unique genetic diversity, socio-cultural determinants, and health inequalities in the continent. It presents numerous brain research initiatives, such as ABDRN, AMARI, APCDR, and H3Africa, aimed at understanding genetic and environmental factors influencing brain disorders in Africa. Despite numerous challenges like the brain drain phenomenon, inadequate infrastructure, and scarce research expertise, significant progress has been achieved. The paper proposes solutions, including international collaboration, capacity-building efforts, and policies to promote neuroscience research, to enhance the understanding of brain function and address brain-related health issues within the African context.

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