The Burden of Influenza: a Complex Problem

Gordon, Aubree; Reingold, Arthur

doi:10.1007/s40471-018-0136-1

Cited by 82 publications

(70 citation statements)

References 53 publications

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“…(1) Strengthening surveillance. The most effective approach to tracking the changes in influenza viruses is facility-based surveillance in the outpatient or hospital (Gordon and Reingold, 2018). The clinical and demographic data of all the cases, including outcome and specimens from the samples of those who meet the case definition(s), need to be reported.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological features and trends of influenza incidence in mainland China: A population-based surveillance study from 2005 to 2015

Sun

Cong

et al. 2019

International Journal of Infectious Diseases

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To investigate epidemiological features and trends of influenza incidence with 1,173,640 cases in mainland China from 2005 to 2015. Methods: Incidence and mortality data for influenza from 2005 to 2015 were provided by the data-center of China public health science and covered a population of about 1.3 billion people from 31 provinces and regions in mainland China. Joinpoint regression and exploratory spatial data analyses were used to examine the incidence trends from 2005 to 2015. Results: The first upsurge in influenza cases occurred in 2009, and the highest incidence of influenza occurred in 2014 (15.9045 cases/100,000 people). The average incidence per year from 2009 to 2015 was threefold higher than that from 2005 to 2008 (10.5308 vs 3.4589 cases/100,000 people; incidence rate ratio = 3.0446). The joinpoint regression results showed that there was an increasing influenza incidence trend from 2005 to 2015 (annual change in percentage = 13.6%, 95%CI 2.2-26.3, p = 0.0236). The seasonal pattern analysis showed that influenza typically occurred in winter and spring during each monitoring year, peaking from November to March the next year. Conclusions: This study will help governments to make valuable decisions in allocating scarce resources and providing strategies to limit the spread of influenza.

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Section: Discussionmentioning

confidence: 99%

Epidemiological features and trends of influenza incidence in mainland China: A population-based surveillance study from 2005 to 2015

Sun

Cong

et al. 2019

International Journal of Infectious Diseases

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“…It is not surprising, indeed, as flu with its flock of non‐specific symptoms is hard to diagnose and flu diagnostic tests are not used in daily emergency management. A recent literature review shows that flu‐resulting mortality is due not to a primary influenza illness but more accurately to co‐morbidity exacerbation and secondary infections …”

Section: Discussionmentioning

confidence: 99%

“…According to Vestergaard et al, this daily excess may vary in between +25% and +50% at the peak of the epidemic. The upper respiratory infection, as flu, have dyspnoea as main symptom . Thus, in the field, we noticed a recrudescence of dyspnoea during the winter virus season (WVS).…”

Section: Introductionmentioning

confidence: 92%

Winter virus season impact on acute dyspnoea in the emergency department

Christiaens

Charpentier

Houzé-Cerfon

et al. 2019

Clinical Respiratory J

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Objective:To compare the epidemiology of dyspnoea presented to emergency departments (EDs) during and of winter virus season (WVS). Methods: This is a monocentric retrospective cohort study. All patients attending to the ED of the Rangueil University Hospital (Toulouse, France) for dyspnoea in September 2016 (off WVS period) and January 2017 (during WVS period) were included. The primary endpoint was the final diagnosis. The patients' medical profiles, care duration, seriousness and futures were studied as secondary endpoints. Results: A total of 395 patients were studied: 125 patients during off-peak influenza season and 270 patients during the peak influenza season. The incidence of patients attending because of dyspnoea increased significantly during WVS (4.2% of ED presentations during the off WVS period versus 8.4% during the WVS period, P < 0.001). Patients attending the ED because of dyspnoea during WVS period were significantly older with more extensive medical backgrounds and more serious diseases. Most of those patients were hospitalized (54%), and largely in the geriatrics department. Conclusion: The incidence of patients attending because of dyspnoea doubled during the WVS period, with patients who were older and had more complex histories. This time-consuming population largely requires hospitalization and may be one of the causes of the emergency department's overcrowding during epidemics. K E Y W O R D S dyspnoea, emergency department, epidemiology, Upper respiratory infection

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“…Seasonal Influenza has been long recognized as a vital cause of morbidity and mortality in humans for years [1]. In 2017 the World Health Organization (WHO) estimated that seasonal influenza was associated with all-cause mortality in about 250,000-500,000 deaths annually [2].…”

Section: Introductionmentioning

confidence: 99%

Cost Effectiveness and Budget Impact Analyses of Influenza Vaccination for Prisoners in Thailand: An Application of System Dynamic Modelling

Suphanchaimat

Doung-ngern

Ploddi

et al. 2020

IJERPH

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Influenza outbreaks in Thai prisons were increasing in number every year and to address this, the Thai Ministry of Public Health (MOPH) initiated a policy to promote vaccination for prisoners. The objective of this study was to assess the cost effectiveness and budget impact of the influenza vaccination policy for prisoners in Thailand. The study obtained data from the Division of Epidemiology, Department of Disease Control (DDC), MOPH. Deterministic system dynamic modelling was exercised to estimate the financial implication of the vaccination programme in comparison with routine outbreak control. The incremental cost-effectiveness ratio (ICER) was calculated via a DDC perspective. The reproductive number was estimated at 1.4. A total of 143 prisons across the country (375,763 prisoners) were analysed. In non-vaccination circumstances, the total healthcare cost amounted to 174.8 million Baht (US$ 5.6 million). Should all prisoners be vaccinated, the total healthcare cost would reduce to 90.9 million Baht (US$ 2.9 million), and 46.8 million Baht (US$ 1.5 million) of this is related to the vaccination. The ICER of vaccination (compared with routine outbreak control) varied between 39,738.0 to 61,688.3 Baht per disability-adjusted life year (DALY) averted (US$ 1281.9–1989.9). Should the vaccination cover 30% of the prisoners, the ICER would be equal to 46,866.8 Baht (US$ 1511.8) per DALY averted with the budget burden amounted to Baht (US$ 4.8 million). The vaccination programme would become more cost-effective if the routine outbreak control was intensified. In summary, the vaccination programme was a cost-effective measure to halt influenza outbreak amongst prisoners. Further primary studies that aim to assess the actual impact of the programme are recommended.

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The Burden of Influenza: a Complex Problem

Cited by 82 publications

References 53 publications

Epidemiological features and trends of influenza incidence in mainland China: A population-based surveillance study from 2005 to 2015

Epidemiological features and trends of influenza incidence in mainland China: A population-based surveillance study from 2005 to 2015

Winter virus season impact on acute dyspnoea in the emergency department

Cost Effectiveness and Budget Impact Analyses of Influenza Vaccination for Prisoners in Thailand: An Application of System Dynamic Modelling

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