The Burden of Mucosal Barrier Injury Laboratory-confirmed Bloodstream Infection Among Hematology, Oncology and Stem Cell Transplant Patients

Establishing nationally representative central line-associated bloodstream infection surveillance data for paediatric patients in Greece

“…This underscores the importance of preventing MBI-LCBI in this vulnerable group of patients. In neutropenic oncology patients, MBI-LCBI frequently involves translocation of oral and gastrointestinal flora into the bloodstream, and may be prevented using oral care bundles [23]. Higher CLABSI rates in our paediatric population were noted compared to ECDC data on adult ICUs from 15 European countries.…”

Bacterial bloodstream infections in the allogeneic hematopoietic cell transplant patient: new considerations for a persistent nemesis

“…5 This distinction may contribute to further reduction in true CLABSI rates in this population 15,[142][143][144] and may provide an opportunity for identification of risk factors specific to MBI-LCBI in HCT patients, enabling more targeted prevention strategies, distinct from current CLABSI prevention strategies. Abbreviations: BSI = bloodstream infection; CLABSI = central line-associated bloodstream infection; ICU = intensive care unit; IQR = interquartile range; MBI-LCBI = mucosal barrier injury laboratory-confirmed bloodstream infection.…”

“…11 Inherent to this distinction is emerging evidence showing that improved CVC maintenance is effective at reducing CLABSI rates, [12][13][14] but not in preventing MBI-LCBIs. 15 CLABSI and MBI-LCBI are terms utilized by the NHSN for BSI surveillance. To augment this the Infectious Disease Society of America (IDSA) produced guidelines for the detection of bacteremia in patients with CVCs utilizing the term 'catheterrelated bloodstream infection' (CRBSI).…”

Low Incidence of Central Venous Catheter–Related Bloodstream Infections in Stem Cell Transplant Patients in Eastern India Despite High Community Burden of Multidrug-Resistant Pathogens

“…A total of 19 BSIs were associated with mucosal barrier injury (MBI-LCBI: mucosal barrier injury-laboratory-confirmed bloodstream infection). 7 Thus, 17 BSIs were associated with central-line infection, with a CLABSI rate of 1.48 per 1,000 catheter days. In addition, 7 (4%) lines were removed for various reasons (eg, exit-site infection, tip migration, fracture of the line).…”