The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

Roy, Natalie; Deveraux, Quinn L.; Takahashi, Ryōsuke; Salvesen, Guy S.; Reed, John C.

doi:10.1093/emboj/16.23.6914

Cited by 1,170 publications

(835 citation statements)

References 67 publications

Supporting

Mentioning

791

Contrasting

Unclassified

Order By: Relevance

“…Similar anti-sense studies, or use of dominant-negative mutants (T34A), have confirmed a role for survivin in conferring apoptotic resistance in prostate cancer [31,32]. In the case of c-IAP2, reports have indicated an association between higher expression levels of c-IAP2 and more aggressive disease, consistent with the documented function of this anti-apoptotic protein as a suppressor of caspases [28].…”

Section: Discussionmentioning

confidence: 54%

“…The activity of caspases-3, -7, and -9 is often further regulated by inhibitor of apoptosis protein (IAP) family members (i.e., c-IAP1 [cellular inhibitor of apoptosis protein 1], c-IAP2, XIAP [X-linked inhibitor of apoptosis protein] and survivin) [27,28]. To date, most studies of this family of proteins have focussed on the expression of survivin.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The multikinase inhibitor sorafenib induces caspase-dependent apoptosis in PC-3 prostate cancer cells

Huang¹,

Chen²,

Zhang³

et al. 2010

Asian J Androl

View full text Add to dashboard Cite

The present study investigated the effects of the multikinase inhibitor sorafenib on androgen-independent cancer cells viability and intracellular signaling. Human androgen-independent PC-3 prostate cancer cells were treated with sorafenib. At concentration that suppresses extracellular signal-regulated kinase phosphorylation, sorafenib treatment reduced the mitochondrial transmembrane potential. Sorafenib also down-modulated the levels of myeloid cell leukemia 1, survivin and cellular inhibitor of apoptosis protein 2. Sorafenib induced caspase-3 cleavage and the mitochondrial release of cytochrome c. However, no nuclear translocation of apoptosis inducing factor was detected after treatment and the pan-caspase inhibitor Z-VAD-FMK had an obvious protective effect against the drug. In conclusion, sorafenib induces apoptosis through a caspase-dependent mechanism with down-regulated antiapoptotic proteins in androgen-independent prostate cancer cells in vitro.

show abstract

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

The multikinase inhibitor sorafenib induces caspase-dependent apoptosis in PC-3 prostate cancer cells

Huang¹,

Chen²,

Zhang³

et al. 2010

Asian J Androl

View full text Add to dashboard Cite

show abstract

“…3,4 API2 is a member of the IAP (inhibitor of apoptosis) gene family, and is essential for the suppression of apoptosis. 5 MALT1, a novel gene, may be involved in NF kappa B activation, 6 however, its biological function is not fully elucidated. Recent data have shown that API2-MALT1 fusion leads to an increased inhibition of apoptosis, which thereby helps MALT lymphomas to survive.…”

mentioning

confidence: 99%

Immunoglobulin VH gene analysis in gastric MALT lymphomas

et al. 2007

View full text Add to dashboard Cite

The majority of gastric mucosa-associated lymphoid tissue (MALT) lymphomas are successfully treated with Helicobacter pylori eradication alone. However, certain subsets of these tumors are resistant to the eradication treatment. As API2-MALT1 fusion is a feature of one of these subsets, we divided gastric MALT lymphomas into three groups: eradication-responsive and API2-MALT1 fusion-negative (Group A), eradication-resistant and fusion-negative (Group B), and eradication-resistant and fusion-positive (Group C). To characterize further gastric MALT lymphomas, we analyzed VH genes, which do not change in the course of tumor progression, by extensive subcloning of the monoclonal PCR products of 45 cases. VH3-23 and VH3-30 were preferentially used in Group A tumors (14/23 cases, 61%) as compared with Group B (1/10 cases, 10%, P ¼ 0.0094) and Group C (2/ 12 cases, 17%, P ¼ 0.017). Tumors of Groups B and C used variegated VH fragments, and no dominant VH fragments were noted. Somatic mutation was detected in most of the cases. Ongoing mutation was detected in 3/45 cases (7%), when assessed according to strict criteria for a confirmed mutation. These findings suggest that inflammation-dependent tumors (Group A) may be derived from a highly restricted, probably H. pyloriassociated, B cell subset and may not often progress to those that are inflammation-independent (Groups B and C). Although considered to be common in this tumor, ongoing mutation may be infrequent when assessed by strict criteria. Keywords: gastric MALT lymphoma; helicobacter pylori; eradication; immunoglobulin heavy chain variable genes; API2-MALT1 fusion gene Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) is a distinct low-grade lymphoma, which is typically localized long term at the site of origin. 1 A preexisting chronic inflammation, such as Helicobacter pylori gastritis, Hashimoto's thyroiditis, or Sjogren's syndrome is considered to influence significantly its development. 1 The etiological link between gastric MALT lymphoma and H. pylori gastritis has arisen from the fact that the majority of gastric MALT lymphomas (approximately 70% of cases) show complete regression on eradication of H. pylori alone. 2 API2-MALT1 fusion, cloned from t(11;18)(q21;q21), is a gene alteration specific to MALT lymphomas. 3,4 API2 is a member of the IAP (inhibitor of apoptosis) gene family, and is essential for the suppression of apoptosis. 5 MALT1, a novel

show abstract

“…BIRs contain a highly conserved arrangement of cysteine and histidine residues that belong to a putative zinc-binding fold. BIRs mediate the interactions between IAPs and various other proteins, including caspases and IBM proteins (Roy et al, 1997;Vucic et al, 1997;Salvesen and Duckett, 2002). BIRs also mediate the formation of IAP homodimers, the apparent functional form of these proteins (Hozak et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Alternative splicing generates multiple transcripts of the inhibitor of apoptosis protein 1 in Aedes and Culex spp. mosquitoes

Beck

Blair

Black

et al. 2007

Insect Biochemistry and Molecular Biology

View full text Add to dashboard Cite

We determined the sequences of cDNA encoding Inhibitor of Apoptosis Protein 1 (IAP1) homologues from Aedes triseriatus, Ae. albopictus, Ae. aegypti, Culex pipiens and Cx. tarsalis. The cDNAs encode translation products that share ≥84% sequence similarity. The IAP1 mRNA of each mosquito species exists as 3 to 5 distinct variants due to the presence of heterogeneous sequences at the distal end of their 5'UTRs. Partial genomic sequencing upstream of the 5' end of the Ae. triseriatus IAP1 gene, and analysis of the Ae. aegypti genomic sequence, suggest that these mRNA variants are generated by alternative splicing. Each IAP1 mRNA variant from Ae. triseriatus and Cx. pipiens was detected by RT-PCR in all mosquito life-stages and adult tissues examined, and the relative concentration of each Ae. triseriatus IAP mRNA variant in various tissues was determined.

show abstract

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

Cited by 1,170 publications

References 67 publications

The multikinase inhibitor sorafenib induces caspase-dependent apoptosis in PC-3 prostate cancer cells

The multikinase inhibitor sorafenib induces caspase-dependent apoptosis in PC-3 prostate cancer cells

Immunoglobulin VH gene analysis in gastric MALT lymphomas

Alternative splicing generates multiple transcripts of the inhibitor of apoptosis protein 1 in Aedes and Culex spp. mosquitoes

Contact Info

Product

Resources

About