The C825T Polymorphism in the G-protein Beta 3 Subunit Gene in Chinese Patients with Preeclampsia

He, Guolin; Liu, Xinghui; Fan, Ping; Liu, Rui; Huang, Yi; Wang, Xiaosu; Li, Qin; Wang, Hongmei; Liu, Yu; Liu, Bingwen; Bai, Huai

doi:10.1080/10641950802366245

Cited by 5 publications

(9 citation statements)

References 28 publications

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“…Previous reports on the association between the rs5443 and preeclampsia have been conflicting. [8][9][10] Our present study, which is much larger than these previous reports, does not support an association between preeclampsia and this polymorphism in a Norwegian population.…”

Section: Discussioncontrasting

confidence: 99%

Single Nucleotide Polymorphisms in G Protein Signaling Pathway Genes in Preeclampsia

et al. 2013

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Preeclampsia is a pregnancy specific disorder and a risk factor for later cardiovascular disease. The cause and detailed pathophysiology remains unknown. G protein signaling is involved in a variety of physiological processes, including blood pressure regulation. We assessed whether distributions of 3 single nucleotide polymorphisms in genes coding for components of G protein signaling pathways that have been associated with hypertension differ between women with preeclampsia and normotensive pregnant women; the G protein β3 subunit gene ( GNB3 ) C825T polymorphism (rs5443), the angiotensin II type 1 receptor gene ( AGTR1 ) 3′UTR A1166C polymorphism (rs5186), and the regulator of G protein signaling 2 gene ( RGS2 ) 3′UTR C1114G polymorphism (rs4606). Two separate Norwegian study populations were used; a large population based study and a smaller, but clinically well-described pregnancy biobank. A descriptive study of 43 women with eclampsia was additionally included. In the population-based study, an increased odds of preeclampsia (odds ratio, 1.21; [95% confidence interval, 1.05–1.40]; P =0.009) and recurrent preeclampsia (odds ratio, 1.43; [95% confidence interval, 1.06–1.92];, P =0.017) was found in women carrying the rs4606 CG or GG genotype. In early-onset preeclamptic patients with decidual spiral artery biopsies available (n=24), the rs4606 CG or GG genotype was more frequent in those with acute atherosis (resembling early stage of atherosclerosis) compared with those without: odds ratio, 15.0; (95% confidence interval, 2.02–111.2); P =0.004. No association was found between preeclampsia and the rs5443 or the rs5186. The genotype distribution in eclamptic women was not different from preeclamptic women. In conclusion, RGS2 rs4606 may affect the risk and progression of preeclampsia.

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Section: Discussioncontrasting

confidence: 99%

Single Nucleotide Polymorphisms in G Protein Signaling Pathway Genes in Preeclampsia

et al. 2013

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“…A familial predisposition to PE has been documented, and both men and women who were the offspring of a pregnancy complicated by PE are significantly more likely to have a pregnancy complicated by PE (Esplin et al, 2001). Although a genetic susceptibility to PE has been established with both maternal and fetal genes and a number of association studies have been performed, the results are inconsistent, and the causative genes involved in PE have yet to be identified (He et al, 2009;Tan et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Meta analysis of angiotensin-converting enzyme I/D polymorphism as a risk factor for preeclampsia in Chinese women

Zhong

Wang²,

Hong³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. Preeclampsia affects 3-8% of pregnancies and is a major cause of maternal and perinatal morbidity and mortality worldwide. Inappropriate activation of the renin-angiotensin system may play a role in the development of preeclampsia. An insertion/ deletion polymorphism in the angiotensin-converting enzyme gene (ACE-I/D) has been associated with differences in ACE activity. However, there are controversies in reports on the association of ACE-I/D with preeclampsia. Data were analyzed using Review Manager Version 5.0 and a random effects model was applied irrespective of between studies heterogeneity, which was evaluated via sensitivity and subgroup analyses. Publication bias was evaluated using the fail-safe number. A systematic search was performed based on published case control studies up to October 1, 2011, and 11 studies were included, involving 800 patients and 949 controls. Significant association of the ACE D allele with increase risk of preeclampsia was found (odds ratio = 1.93, 95% confidence interval = 1.19-3.12; P = 0.008). Sensitivity analysis showed that no individual study had an undue influence on the ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 11 (3): 2268-2276 (2012) Angiotensin-converting enzyme polymorphism and preeclampsia 2269 summary odds ratios for all contrasts. An analysis stratified by study size showed an attenuated odds ratio towards a null effect as study size increased. Based on our meta-analysis, we suggest that the D allele of the ACE gene is related with increased risk for preeclampsia in the Chinese population. Considering the potential existence of small study bias, further research should be performed with a larger dataset.

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“…Ultimately, eight studies from seven publications were included in the meta‐analysis (Figure 1). 18,19,25‐29 …”

Section: Resultsmentioning

confidence: 99%

“…Among the eight studies, five were reported before 2010 18,19,25,26 and three after 2010. [27][28][29] Five studies were written in English, 18,19,26,27 two in Russian, 28,29 and one in Chinese. 25 The participants were from Europe, 19,[27][28][29] Asia, 25,26 and North America.…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

Meta‐analysis of the genetic association between maternal GNB3 C825T polymorphism and risk of pre‐eclampsia

Song

Huang

Zhou

et al. 2021

Intl J Gynecology & Obste

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Background The relationship between the C825T polymorphism of GNB3 (encoding G‐protein β3 subunit) and pre‐eclampsia risk is unclear. Objective To systematically explore the association between GNB3 C825T and pre‐eclampsia. Search strategy PubMed, EMBASE, Google Scholar, and Chinese National Knowledge Infrastructure (CNKI) databases were searched to September 1, 2020, using keywords including “GNB3 C825T” and “pre‐eclampsia”. Selection criteria Case–control and cohort studies investigating the relationship between GNB3 C825T polymorphism and pre‐eclampsia were included. Data collection and analysis Two reviewers collected the data independently and calculate odds ratios (ORs) with 95% confidence intervals (CIs). Main results The meta‐analysis involved eight studies from seven publications, including 2071 cases and 3419 controls. Overall analysis showed that GNB3 C825T was associated with increased pre‐eclampsia risk in the recessive model (OR, 1.21; 95% CI, 1.01–1.44; P = 0.04). Subgroup analysis stratified by Hardy–Weinberg equilibrium revealed a relationship between GNB3 C825T and increased risk of pre‐eclampsia in the allelic (OR, 1.66; 95% CI, 1.34–2.05; P < 0.001), homozygous (OR, 2.12, 95% CI, 1.04–4.32; P = 0.04), dominant (OR, 1.91; 95% CI, 1.18–3.11; P = 0.009), and recessive (OR, 1.70; 95% CI, 1.03–2.81; P = 0.04) models. Conclusions Maternal GNB3 C825T polymorphism seems to be a risk factor for pre‐eclampsia.

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The C825T Polymorphism in the G-protein Beta 3 Subunit Gene in Chinese Patients with Preeclampsia

Abstract: Our work does not provide evidence in favor of GNB3 C825T being a candidate gene for conferring genetic susceptibility to preeclampsia in a South West Chinese population.

Cited by 5 publications

References 28 publications

Single Nucleotide Polymorphisms in G Protein Signaling Pathway Genes in Preeclampsia

Single Nucleotide Polymorphisms in G Protein Signaling Pathway Genes in Preeclampsia

Meta analysis of angiotensin-converting enzyme I/D polymorphism as a risk factor for preeclampsia in Chinese women

Meta‐analysis of the genetic association between maternal GNB3 C825T polymorphism and risk of pre‐eclampsia

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