The capnellenes revisited: New structures and new biological activity

Morris, Linda A.; Jaspars, Marcel; Adamson, Katy; Woods, Samantha; Wallace, Heather M.

doi:10.1016/s0040-4020(98)00784-4

Cited by 24 publications

(37 citation statements)

References 8 publications

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“…The NMR data of 6 (for 13 C-NMR, see Table 3 in Exper. Part) were in agreement with those reported in [16].…”

supporting

confidence: 92%

“…These data are in agreement with our results for compounds 6 and 7. Monohydroxycapnellene 8 and monoacetoxycapnellene 9 were effective against K-562 and A-2780 cell lines [16].…”

mentioning

confidence: 96%

“…The soft corals of the family Nephtheidae, order Alcyonacea, are known for their content of sesquiterpenes and particularly capnellenes [11 -16]. Hydroxy-and acetoxycapnellenes, and precapnelladiene have been isolated before from the soft coral Capnella imbricata [15] [16].Capnell-9(12)-ene-8b,10a-diol (6), capnell-9(12)-ene-8b-ol (8), and 3b-acetoxycapnell-9(12)-ene-8b,10a,14-triol (9) have been tested against the cancer cell lines HL-60, K-562 (human leukemia), G-402 (human renal leiomyoblastoma), MCF-7 (human breast carcinoma), A-2780 (human adenocarcinoma), and HT-115 (human colon carcinoma) [16]. Compound 6 was antiproliferative and cytotoxic in all cell lines tested with IC 50 values in the range of 0.7 -93 mm.…”

mentioning

confidence: 99%

“…Capnell-9(12)-ene-8b,10a-diol (6), capnell-9(12)-ene-8b-ol (8), and 3b-acetoxycapnell-9(12)-ene-8b,10a,14-triol (9) have been tested against the cancer cell lines HL-60, K-562 (human leukemia), G-402 (human renal leiomyoblastoma), MCF-7 (human breast carcinoma), A-2780 (human adenocarcinoma), and HT-115 (human colon carcinoma) [16]. Compound 6 was antiproliferative and cytotoxic in all cell lines tested with IC 50 values in the range of 0.7 -93 mm.…”

mentioning

confidence: 99%

“…Part [17]. Dihydroxycapnellene 6 showed against the cell lines HL-60, K-562, G-402, MCF-7, and HT-115 a higher activity than monohydroxycapnellene 8 [16]. The monoacetoxycapnellene 9 exhibited a lower activity against the HL-60, K-562, and A-2780 cells compared with 6 and 8.…”

mentioning

confidence: 99%

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Capnellenes from the Soft Coral Dendronephthya rubeola

Grote

Hänel

Dahse

et al. 2008

Chemistry & Biodiversity

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Four new acetoxycapnellenes 1-4, the first epoxyprecapnellene 5, along with the known dihydroxycapnellene 6 and monoacetoxycapnellene 7, have been isolated from the soft coral Dendronephthya rubeola. The structures were determined primarily by NMR spectroscopy. The compounds 6 and 7 showed a good antiproliferative activity against the cell line L-929 (murine fibroblasts) and a good cytotoxic activity against the HeLa (human cervix carcinoma) cell line. Compound 6 strongly inhibits the interaction of the oncogenic transcription factor Myc with its partner protein Max. Myc/Max-Interaction inhibitors are therapeutically interesting compounds in oncology.

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“…The NMR data of 6 (for 13 C-NMR, see Table 3 in Exper. Part) were in agreement with those reported in [16].…”

supporting

confidence: 92%

“…These data are in agreement with our results for compounds 6 and 7. Monohydroxycapnellene 8 and monoacetoxycapnellene 9 were effective against K-562 and A-2780 cell lines [16].…”

mentioning

confidence: 96%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Capnellenes from the Soft Coral Dendronephthya rubeola

Grote

Hänel

Dahse

et al. 2008

Chemistry & Biodiversity

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Cnidaria and Ctenophora–1

Kornprobst

2014

Encyclopedia of Marine Natural Products

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The article contains sections titled: General Introduction Simplified Classification of Cnidaria Hermatypic and Ahermatypic Corals: Coral Bleaching General Information on Metabolites of Cnidaria Membrane Constituents and Secondary Metabolites of Octocorallia (Anthozoa) Prostaglandins and Prostanoids Phospholipid Fatty Acids, Glycolipids, and Other Lipidic Derivatives General Remarks on the Sterols of Octocorallia Gorgosterol and Other Cyclopropane‐Containing Sterols 19‐Oxygenated‐ and 19‐ nor ‐Steroids Polyoxygenated Steroids Sterones and Chlorinated Sterones Sulfur‐Containing Steroids Cyclized Side‐Chain Sterols Secosterols Sterosides, Pregnane, and nor ‐Pregnane Derivatives Sesquiterpenic Hydrocarbons Halogen‐, Nitrogen‐, and Sulfur‐Containing Sesquiterpenes Sesquiterpenes with Original Carbon Skeletons Examples of Sesquiterpenes with a Classical Carbon Skeleton General Account of Diterpenes Linear and Monocyclic Diterpenes General Information on Bicyclic Diterpenes Chlorinated Diterpenes Other examples of Briarane Derivatives Nitrogen‐Containing Diterpenes of Cladiellane/Eunicellane: Eleutherobin and Analogs, Labiatamides Other Examples of Cladiellane/Eunicellane Diterpenes Diterpenes of Serrulatane and Other Bicyclic Carbon Skeletons Bicyclic C 5 /C 11 Diterpenes Bicyclic Diterpenes Containing a Cyclopropane Some Other Examples of Bicyclic Diterpenes General Account of Tricyclic Diterpenes Pseudopterosins, Other Amphilectane Derivatives and Analogs Other Examples of Tricyclic and Tetracyclic Diterpenes Comments on the Origin of Terpenes Non‐Terpenic Nitrogenous Derivatives of Octocorallia Uncommon Sulfur‐Containing Compounds

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Cnidaria and Ctenophora–2

Kornprobst

2014

Encyclopedia of Marine Natural Products

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The article contains sections titled: Membrane Constituents and Secondary Metabolites of Hexacorallia (Anthozoa) Fatty Acids, Oxylipins, and Acetylenic Derivatives Sterols and Ecdysteroids Terpenes Carotenoids of Sea Anemones Aromatic Derivatives Ceramides and Lipidic α‐Amino Acids Examples of Nitrogenous Pigments: Zoanthoxanthins and Calliactine Palytoxins ( PTXs ) Mycosporines Betaines, Phosphobetaines, Purines, and Other Nitrogen‐Containing Derivatives Zoanthamine Alkaloids Cytolysins, Neuropeptides, and Other Venoms of Sea Anemones Venoms and Other Metabolites of Medusozoa Some Data on the Cubozoa and Other Jellyfish Bioluminescence of Jellyfish and Other Cnidaria Some Results on the Secondary Metabolites of Other Hydrozoa Ctenophora

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The capnellenes revisited: New structures and new biological activity

Cited by 24 publications

References 8 publications

Capnellenes from the Soft Coral Dendronephthya rubeola

Capnellenes from the Soft Coral Dendronephthya rubeola

Cnidaria and Ctenophora–1

Cnidaria and Ctenophora–2

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