The Cardiac Atlas Project: Development of a Framework Integrating Cardiac Images and Models

Backhaus, Michael; Britten, Randall; Chung, Jae Do; Cowan, Brett R.; Fonseca, Carissa G.; Medrano-Gracia, Pau; Tao, Wenchao; Young, Alistair A.

doi:10.1007/978-3-642-15835-3_6

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…Recent advances in machine learning algorithms are providing encouraging results that indicate that entirely automated analysis of cardiac function may be available even within the initial phases of the UK Biobank imaging enhancements [39]. The Cardiac Atlas Project combined images and results from MESA and the Jackson Heart Study to enable meta-analyses of probabilistic cardiac shape and function patterns [40,41]. This could be extended to the larger number of participants in UK Biobank.…”

Section: Reviewmentioning

confidence: 99%

Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches

Petersen

Matthews

Bamberg

et al. 2013

Journal of Cardiovascular Magnetic Resonance

217

183

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UK Biobank is a prospective cohort study with 500,000 participants aged 40 to 69. Recently an enhanced imaging study received funding. Cardiovascular magnetic resonance (CMR) will be part of a multi-organ, multi-modality imaging visit in 3–4 dedicated UK Biobank imaging centres that will acquire and store imaging data from 100,000 participants (subject to successful piloting). In each of UK Biobank’s dedicated bespoke imaging centres, it is proposed that 15–20 participants will undergo a 2 to 3 hour visit per day, seven days a week over a period of 5–6 years. The imaging modalities will include brain MRI at 3 Tesla, CMR and abdominal MRI at 1.5 Tesla, carotid ultrasound and DEXA scans using carefully selected protocols. We reviewed the rationale, challenges and proposed approaches for concise phenotyping using CMR on such a large scale. Here, we discuss the benefits of this imaging study and review existing and planned population based cardiovascular imaging in prospective cohort studies. We will evaluate the CMR protocol, feasibility, process optimisation and costs. Procedures for incidental findings, quality control and data processing and analysis are also presented. As is the case for all other data in the UK Biobank resource, this database of images and related information will be made available through UK Biobank’s Access Procedures to researchers (irrespective of their country of origin and whether they are academic or commercial) for health-related research that is in the public interest.

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Section: Reviewmentioning

confidence: 99%

Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches

Petersen

Matthews

Bamberg

et al. 2013

Journal of Cardiovascular Magnetic Resonance

217

183

View full text Add to dashboard Cite

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The Cardiac Atlas Project: Rationale, Design and Procedures

Fonseca¹,

Backhaus

Chung

et al. 2010

Statistical Atlases and Computational Models of the Heart

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Computational modeling of the human atrial anatomy and electrophysiology

Dössel

Krueger

Weber

et al. 2012

Med Biol Eng Comput

127

122

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This review article gives a comprehensive survey of the progress made in computational modeling of the human atria during the last 10 years. Modeling the anatomy has emerged from simple "peanut"-like structures to very detailed models including atrial wall and fiber direction. Electrophysiological models started with just two cellular models in 1998. Today, five models exist considering e.g. details of intracellular compartments and atrial heterogeneity. On the pathological side, modeling atrial remodeling and fibrotic tissue are the other important aspects. The bridge to data that are measured in the catheter laboratory and on the body surface (ECG) is under construction. Every measurement can be used either for model personalization or for validation. Potential clinical applications are briefly outlined and future research perspectives are suggested.

show abstract

The Cardiac Atlas Project: Development of a Framework Integrating Cardiac Images and Models

Cited by 4 publications

References 9 publications

Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches

Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches

The Cardiac Atlas Project: Rationale, Design and Procedures

Computational modeling of the human atrial anatomy and electrophysiology

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