The Case ∣ A Caucasian male with dark skin, black urine, and acute kidney injury

Santos, Arvin L; Ibrahim, Garad; Mount, Sharon L.; Thomas, Christian A.; Weise, W

doi:10.1038/ki.2009.388

Cited by 4 publications

(5 citation statements)

References 4 publications

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“…Likewise, black urine is an extremely rare entity that has been rarely discussed. Black urine, termed melanuria, is an uncommon finding in patients with disseminated melanoma [5] . In our case, other causes of dark urine such as gross haematuria, alkaptonuria, porphyria and rhabdomyolysis were either ruled out or were considered highly unlikely given the above findings.…”

Section: Discussionmentioning

confidence: 99%

“…In our case, other causes of dark urine such as gross haematuria, alkaptonuria, porphyria and rhabdomyolysis were either ruled out or were considered highly unlikely given the above findings. In melanuria, as well as in black pleural effusion, the urine is yellow and darkens as the colourless melanin precursors oxidize in the presence of air [5] .…”

Section: Discussionmentioning

confidence: 99%

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Black Urine and Black Pleural Fluid: A Distinctive Presentation of Metastatic Melanoma

Mishe'el

Ziv

Bisharat

2016

European Journal of Case Reports in Internal Medicine

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Metastatic melanoma is an uncommon clinical entity which can have an unusual presentation. We describe a patient with metastatic melanoma who presented with diffuse melanosis cutis, black urine and black pleural effusion. Very few medical conditions can cause black discoloration of body fluids, so this should prompt physicians to search for a number of potential underlying causes. LEARNING POINTS• Diffuse melanosis cutis is a rare presentation of metastatic melanoma.• Malignant melanoma with thoracic metastases can cause a black pleural effusion.• Physicians should be aware of potential causes of black discoloration of body fluids. KEYWORDS Melanoma; pleural effusion; diffuse melanosis cutis; black urine. INTRODUCTIONMalignant melanoma is the most serious of the skin cancers and has shown an increasing incidence over the past 30 years

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Black Urine and Black Pleural Fluid: A Distinctive Presentation of Metastatic Melanoma

Mishe'el

Ziv

Bisharat

2016

European Journal of Case Reports in Internal Medicine

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“…Santos, et al also reported a patient with metastatic melanoma to the liver and diffuse melanosis, who presented in renal failure with melanuria. However, the etiology of the acute kidney injury in this case was determined to be due to hepatorenal syndrome given the absence of proteinuria, no red or white cells in the urine, low urine sodium, and lack of improvement with volume expansion [8].…”

Section: Discussionmentioning

confidence: 87%

Two Rare Mechanisms for Acute Anuric Renal Failure in a Patient with Metastatic Malignant Melanoma - A Case Report

D¹,

J²,

M³

et al. 2019

J Clin Nephrol Ren Care

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This case report examines two rare mechanisms of acute renal failure in a patient with metastatic melanoma treated with high-dose vitamin C. The first is oxalate nephropathy, which is an uncommon but known complication of highdose vitamin C therapy in naturopathic medicine. The second is due to melanuria and renal melanosis, which has been described in metastatic melanoma; however, acute renal failure requiring renal replacement therapy has not been reported previously.

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“…There are multiple mechanisms that produce black urine in malignant melanoma. During production of melanin from tyrosine, an intermediate metabolite, 5 : 6 dihydroxy-indole, and other phenolic metabolites of melanogens contribute to the black color [47, 48]. It can also occur due to melanin precursors like dopamine undergoing autooxidation on contact with air to form melanin [49].…”

Section: Black Urinementioning

confidence: 99%

Urine Bag as a Modern Day Matula

Viswanathan

2013

ISRN Nephrology

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Since time immemorial uroscopic analysis has been a staple of diagnostic medicine. It received prominence during the middle ages with the introduction of the matula. Urinary discoloration is generally due to changes in urochrome concentration associated with the presence of other endogenous or exogenous pigments. Observation of urine colors has received less attention due to the advances made in urinalysis. A gamut of urine colors can be seen in urine bags of hospitalized patients that may give clue to presence of infections, medications, poisons, and hemolysis. Although worrisome to the patient, urine discoloration is mostly benign and resolves with removal of the offending agent. Twelve urine bags with discolored urine (and their predisposing causes) have been shown as examples. Urine colors (blue-green, yellow, orange, pink, red, brown, black, white, and purple) and their etiologies have been reviewed following a literature search in these databases: Pubmed, EBSCO, Science Direct, Proquest, Google Scholar, Springer, and Ovid.

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The Case ∣ A Caucasian male with dark skin, black urine, and acute kidney injury

Cited by 4 publications

References 4 publications

Black Urine and Black Pleural Fluid: A Distinctive Presentation of Metastatic Melanoma

Black Urine and Black Pleural Fluid: A Distinctive Presentation of Metastatic Melanoma

Two Rare Mechanisms for Acute Anuric Renal Failure in a Patient with Metastatic Malignant Melanoma - A Case Report

Urine Bag as a Modern Day Matula

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