This paper analyses the digital ecosystem (DES), entrepreneurial ecosystem (EES) and economic development (ED) indicators as key determinants of digital technology entrepreneurship (DTE) across the globe. The correlation matrix depicts an important relationship between DTE, DES, EES and ED. Further, the partial least squares structural equation modelling (PLS‐SEM) results show that DES and EES have a favourable and significant influence on the establishment of digital technology entrepreneurship (DTE) globally. However, the ED, though, has a positive and significant impact on EES and DES, not directly impacting DTE. The study is useful to various stakeholders such as entrepreneurs, funding agencies, policymakers and researchers in their decision‐making process.