2024
DOI: 10.21203/rs.3.rs-3948492/v1
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The Causal Relationship Between Blood Cell Indices and 28-Day Mortality in Sepsis: A Bidirectional Mendelian Randomization Analysis

Tao Zeng,
Yina Sun,
Shuru Chen
et al.

Abstract: Background: Despite emerging evidence linking blood cell indices (BCIs) to sepsis mortality, the inconsistency of observational studies obscures the clarity of these associations. This study aims to clarify the causal influence of BCIs on 28-day mortality rates in sepsis patients. Methods Utilizing univariable and multivariable Mendelian randomization (MR) analyses, we examined the impact of BCIs on sepsis mortality by analyzing data from extensive genome-wide association studies. The inverse-variance weighted… Show more

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