The Causes of Hospital-Treated Acute Lower Respiratory Tract Infection in Children

Nohynek, Hanna; Eskola, Juhani; Laine, Eija; Halonen, Pekka; Ruutu, Petri; Saikku, Pekka; Kleemola, Marjaana; Leinonen, Maija

doi:10.1001/archpedi.1991.02160060036016

Cited by 72 publications

(72 citation statements)

References 24 publications

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“…These results may corroborate previously reported etiological rates; in previous studies, the rate has been reported as 43% to 85% (14)(15)(16)(17)(18)(19)(20).…”

Section: Resultssupporting

confidence: 93%

Identification of respiratory viral infection agents by multiplex real-time PCR among children hospitalized for community-acquired pneumonia in Konya province

Sert¹,

Keşli²,

Odabaş³

et al. 2012

Turk Hij Den Biyol Derg

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“…These results may corroborate previously reported etiological rates; in previous studies, the rate has been reported as 43% to 85% (14)(15)(16)(17)(18)(19)(20).…”

Section: Resultssupporting

confidence: 93%

Identification of respiratory viral infection agents by multiplex real-time PCR among children hospitalized for community-acquired pneumonia in Konya province

Sert¹,

Keşli²,

Odabaş³

et al. 2012

Turk Hij Den Biyol Derg

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“…In the present study, the positivity of hemocultures was 38.5% (30 cases). Mixed lower respiratory tract infections are not uncommon, varying from 16 to 30%, especially in children under two years old 18,23,35 . Hence, the data of the present work appears to correspond to the etiologic patterns described by these authors.…”

Section: Discussionmentioning

confidence: 99%

Incidence of respiratory viruses in preterm infants submitted to mechanical ventilation

Diniz

Vieira

Ceccon

et al. 2005

Rev. Inst. Med. trop. S. Paulo

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The objectives of this study were to determine the incidence of infection by respiratory viruses in preterm infants submitted to mechanical ventilation, and to evaluate the clinical, laboratory and radiological patterns of viral infections among hospitalized infants in the neonatal intensive care unit (NICU) with any kind of acute respiratory failure. Seventy-eight preterm infants were studied from November 2000 to September 2002. The newborns were classified into two groups: with viral infection (Group I) and without viral infection (Group II). Respiratory viruses were diagnosed in 23 preterm infants (29.5%); the most frequent was respiratory syncytial virus (RSV) (14.1%), followed by influenza A virus (10.2%). Rhinorrhea, wheezing, vomiting and diarrhea, pneumonia, atelectasis, and interstitial infiltrate were significantly more frequent in newborns with nosocomial viral infection. There was a correlation between nosocomial viral infection and low values of C-reactive protein. Two patients with mixed infection from Group I died during the hospital stay. In conclusion, RSV was the most frequent virus in these patients. It was observed that, although the majority of viral lower respiratory tract infections had a favorable course, some patients presented a serious and prolonged clinical manifestation, especially when there was concomitant bacterial or fungal infection.

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“…Nohynek et al 86 , utilizando métodos de diagnóstico convencionais e sorológicos em 135 crianças finlandesas hospitalizadas por pneumonia, verificaram que em 25% dos casos houve identificação de um agente bacteriano, e em 25% um agente viral, sendo que em 20% dos casos a infecção foi mista. Houve identificação do agente etiológico em 70% dos casos.…”

Section: Etiologia Das Pneumonias Agudas Adquiridas Na Comunidade (Paunclassified

Diagnóstico etiológico das pneumonias: uma visão crítica

Rodrigues

Filho

Bush

2002

J. Pediatr. (Rio J.)

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Objetivo: revisar a literatura quanto ao diagnóstico etiológico das pneumonias agudas na faixa etária pediátrica. Fonte dos dados: revisão sistemática das citações do Medline e do Lilacs.Síntese dos dados: a utilização dos novos métodos diagnósticos, particularmente as técnicas imunológicas e a reação em cadeia da polimerase, de uso ainda incipiente no Brasil, tem se mostrado importante para a investigação epidemiológica e para a melhora no diagnóstico específico em termos de sensibilidade, especificidade e rapidez de resultados, com finalidade de orientação terapêutica adequada. A revisão dos estudos epidemiológicos das pneumonias agudas adquiridas na comunidade mostrou que o Streptococcus pneumoniae continua sendo o agente bacteriano mais importante, em todas as faixas etárias, tanto nos países desenvolvidos quanto nos em desenvolvimento. A resistência desse agente à penicilina e às cefalosporinas tem aumentado progressivamente em todos os continentes e tem-se constituído em um fator de preocupação. Os agentes de pneumonias atípicas, Mycoplasma pneumoniae e Chlamydia pneumoniae mostram-se, atualmente, como agentes importantes de pneumonias agudas adquiridas na comunidade, particularmente em crianças acima de 4 a 5 anos de idade, correspondendo, em países desenvolvidos, a cerca de até um terço dos casos. No entanto, ainda não está definida a sua importância epidemiológica nos países em desenvolvimento. O vírus respiratório sincicial é um agente freqüente de pneumonias agudas adquiridas na comunidade, pode determinar quadros mais graves, particularmente nos lactentes e crianças menores, sendo muito importante a sua investigação em crianças hospitalizadas por doença do trato respiratório inferior. A utilização das novas vacinas conjugadas contra Streptococcus pneumoniae e Haemophilus influenzae tipo b tiveram um impacto importante na morbidade e mortalidade das infecções causadas por esse agentes.Conclusões: a monitorização microbiológica e antimicrobiana deve ser um trabalho dinâmico e contínuo, e a procura e o desenvolvimento de novas vacinas, particularmente contra o VRS, poderá causar um grande impacto na prevenção das pneumonias agudas na infância.J Pediatr (Rio J) 2002; 78 (Supl.2): S129-S140: pneumonia, pneumopatias, diagnóstico. AbstractObjectives: to search literature related to the etiological diagnosis of acute pneumonia in children. Sources: systematic review of Medline and Lilacs databases.Summary of the findings: the use of new diagnostic methods such as immunological techniques and polymerase chain reaction has proven invaluable for specific diagnosis and epidemiological investigation, showing adequate sensitivity, specificity and promptness of results, with the aim of guiding therapy properly. Review of epidemiological studies of community acquired pneumonia showed that Streptococcus pneumoniae is still one of the most significant etiologic agents in all age groups, in developing and industrialized countries. Resistance of this agent to penicillin and cephalosporins is increasing in all continents...

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The Causes of Hospital-Treated Acute Lower Respiratory Tract Infection in Children

Cited by 72 publications

References 24 publications

Identification of respiratory viral infection agents by multiplex real-time PCR among children hospitalized for community-acquired pneumonia in Konya province

Identification of respiratory viral infection agents by multiplex real-time PCR among children hospitalized for community-acquired pneumonia in Konya province

Incidence of respiratory viruses in preterm infants submitted to mechanical ventilation

Diagnóstico etiológico das pneumonias: uma visão crítica

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