The CB2 cannabinoid receptor regulates human sperm cell motility

Agirregoitia, Ekaitz; Carracedo, Arkaitz; Subirán, Nerea; Valdivia, Asier; Agirregoitia, Naiara; Peralta, Laura; Velasco, Guillermo; Irazusta, Jon

doi:10.1016/j.fertnstert.2009.01.153

Cited by 70 publications

(72 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Here, these receptors are present in the postacrosomal region, midpiece, and tail of spermatozoa [46]. CB2 receptors were also found to be present on Sertoli cells [49].…”

Section: The Cannabinoid Receptorsmentioning

confidence: 72%

“…In the male reproductive system, they are located in the testis, prostate, and vas deferens [44,45]. In humans, CB1 receptors are also expressed on the plasma membrane of the acrosomal region, midpiece, and on the tail of spermatozoa [46]. Rossato et al [47] on the other hand showed the CB1 receptor to be only present in the sperm head and midpiece, but not the tail.…”

Section: The Cannabinoid Receptorsmentioning

confidence: 99%

“…Initially, there was lack of clarity regarding the presence of CB2 receptors in spermatozoa, but a study conducted by Agirregoita et al confirmed the presence of the CB2 receptor in human spermatozoa [46].…”

Section: The Cannabinoid Receptorsmentioning

confidence: 99%

“…CB1 has been localized to the plasma membrane of the acrosomal region, midpiece, and tail of the spermatozoon, while CB2 receptors are mostly localized in the postacrosomal region as well as midpiece and tail [46,47,64]. The transporters as well as enzymes responsible for synthesis and hydrolysis of endocannabinoids have also been identified in the male gametes of various species, including humans.…”

Section: Ecs and Sperm Functionmentioning

confidence: 99%

“…[23] AEA can also move back into the cell via the EMT. Once outside, it can act on both CB1 and CB2 receptors [46]. Activation of these receptors modulates the motility of spermatozoa.…”

Section: Ecs and Sperm Functionmentioning

confidence: 99%

See 4 more Smart Citations

Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility

Plessis

Agarwal

Syriac

2015

J Assist Reprod Genet

126

View full text Add to dashboard Cite

Marijuana has the highest consumption rate among all of the illicit drugs used in the USA, and its popularity as both a recreational and medicinal drug is increasing especially among men of reproductive age. Male factor infertility is on the increase, and the exposure to the cannabinoid compounds released by marijuana could be a contributing cause. The endocannabinoid system (ECS) is deeply involved in the complex regulation of male reproduction through the endogenous release of endocannabinoids and binding to cannabinoid receptors. Disturbing the delicate balance of the ECS due to marijuana use can negatively impact reproductive potential. Various in vivo and in vitro studies have reported on the empirical role that marijuana plays in disrupting the hypothalamus-pituitary-gonadal axis, spermatogenesis, and sperm function such as motility, capacitation, and the acrosome reaction. In this review, we highlight the latest evidence regarding the effect of marijuana use on male fertility and also provide a detailed insight into the ECS and its significance in the male reproductive system.

show abstract

“…Here, these receptors are present in the postacrosomal region, midpiece, and tail of spermatozoa [46]. CB2 receptors were also found to be present on Sertoli cells [49].…”

Section: The Cannabinoid Receptorsmentioning

confidence: 72%

Section: The Cannabinoid Receptorsmentioning

confidence: 99%

Section: The Cannabinoid Receptorsmentioning

confidence: 99%

Section: Ecs and Sperm Functionmentioning

confidence: 99%

“…[23] AEA can also move back into the cell via the EMT. Once outside, it can act on both CB1 and CB2 receptors [46]. Activation of these receptors modulates the motility of spermatozoa.…”

Section: Ecs and Sperm Functionmentioning

confidence: 99%

See 3 more Smart Citations

Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility

Plessis

Agarwal

Syriac

2015

J Assist Reprod Genet

126

View full text Add to dashboard Cite

show abstract

Disorders of Male Reproductive Endocrinology

Carroll¹

2018

Clinical Reproductive Science

View full text Add to dashboard Cite

The effects of cannabidiol on male reproductive system: A literature review

Carvalho

Andersen

Mazaro-Costa

2019

J of Applied Toxicology

View full text Add to dashboard Cite

Cannabidiol (CBD) is one of the most abundant phytocannabinoids present in the plant Cannabis sativa (marijuana). There have been several studies of CBD in the last few decades, mainly focused on its neuroprotective properties, particularly after the identification of the endocannabinoid system and its participation in the central nervous system. On the other hand, the peripheral effects of CBD, particularly on reproductive physiology, were also evidenced. A narrative review was conducted using the PubMed database to identify studies that analyzed the pharmacological effects of CBD on the male reproductive system of vertebrates and invertebrates. Thirty‐two citations (in vivo and in vitro) were identified. Among the vertebrates, the studies were carried out with men, monkeys, rats and mice. Studies with invertebrates are centered exclusively on the sea urchin. The CBD treatment periods include mostly acute and subacute evaluations. Exposure to CBD is associated with a reduction in mammalian testis size, the number of germ and Sertoli cells in spermatogenesis, fertilization rates, and plasma concentrations of hypothalamic, pituitary and gonadal hormones. Moreover, chronic doses of CBD have impaired sexual behavior in mice. From the studies identified in this review, it is possible to conclude that CBD has negative effects on the reproductive system of males. However, knowledge is still limited, and additional research is required to elucidate fully the mechanisms of action, as well as the reversibility of CBD effects on the reproductive system.

show abstract

The CB2 cannabinoid receptor regulates human sperm cell motility

Cited by 70 publications

References 52 publications

Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility

Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility

Disorders of Male Reproductive Endocrinology

The effects of cannabidiol on male reproductive system: A literature review

Contact Info

Product

Resources

About