The CCND1 G870A Gene Polymorphism and Brain Tumor Risk: a Meta-analysis

Qin, Lingyan; Zhao, Ligang; Xu, Chunli; Li, Ping; Yang, Zuozhang; Mo, Wuning

doi:10.7314/apjcp.2014.15.8.3607

Cited by 13 publications

(12 citation statements)

References 31 publications

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“…However, in children, females were more affected. A systematic review by Qin et al (2014) has shown that genetic DOI:http://dx.doi.org/10.7314/APJCP.2014.15.22…”

Section: Discussionmentioning

confidence: 99%

Brief Descriptive Epidemiology of Primary Malignant Brain Tumors from North-East India

Krishnatreya¹,

Kataki²,

Sharma³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Brain tumors are a mixed group of neoplasms that originate from the intracranial tissues and the meninges with degrees of malignancy varying greatly from benign to aggressive. Not much is known about the epidemiology of primary malignant brain tumors (PMBTs) in our population in North-East India. In this analysis, an attempt was made to identify the age groups, gender distribution, topography and different histological types of PMBT with data from a hospital cancer registry. A total of 231 cases of PMBT were identified and included for the present analysis. Our analysis has shown that most of PMBT occur at 20-60 years of age, with a male to female ratio of 2.3:1. Some 70.5% of cases occurred in cerebral lobes except for the occipital lobe, and astrocytic tumors were the most common broad histological type. In our population the prevalence of PMBT is 1% of all cancers, mostly affecting young and middle aged patients. As brain tumors are rare, so case-control analytic epidemiological studies will be required to establish the risk factors prevalent in our population.

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“…However, in children, females were more affected. A systematic review by Qin et al (2014) has shown that genetic DOI:http://dx.doi.org/10.7314/APJCP.2014.15.22…”

Section: Discussionmentioning

confidence: 99%

Brief Descriptive Epidemiology of Primary Malignant Brain Tumors from North-East India

Krishnatreya¹,

Kataki²,

Sharma³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Hai Lin 1 , Lian Fang 1, 2 , Dong Lin 3 * at codon 241 in exon 4 resulting in the elevated mRNA alternative splicing, which leads to an altered protein having a longer half-life (Qin et al, 2014). Carries of CCND1 A allele may have a longer half-life and bypass the G1/S checkpoint more easily than the G allele, and is crucial in the carcinogenesis and development of brain tumors (Zeybek et al, 2013).…”

Section: Association Of Cyclin D1 Variants With Head and Neck Cancer mentioning

confidence: 99%

Association of Cyclin D1 Variants with Head and Neck Cancer Susceptibility: Evidence from a Meta-analysis

Lin

Lian²,

Lin³

2014

Asian Pacific Journal of Cancer Prevention

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“…Cyclin D1 encoded by the CCND1 gene is a key positive regulatory protein of the G1/S phase in the cell cycle. Variations of CCND1 have been detected in many cancers and CCND1 rs9344 polymorphism has been frequently reported to be related with several cancers including NPC [17–20]. One study found that the G allele of CCND1 rs9344 polymorphism was associated with a decreased risk of developing NPC [21].…”

Section: Introductionmentioning

confidence: 99%

The impacts of single nucleotide polymorphisms in genes of cell cycle and NF-κB pathways on the efficacy and acute toxicities of radiotherapy in patients with nasopharyngeal carcinoma

Guo

Huang

et al. 2017

Oncotarget

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Radiotherapy is one of the primary choices for the treatment of nasopharyngeal carcinoma (NPC) and may result in severe radiotoxicities on normal tissues. Single nucleotide polymorphisms (SNPs) in genes of cell cycle and NF-κB pathways have been linked with the prognoses of various cancers. The aim of this study was to explore whether SNPs of genes involved in cell cycle and NF-κB pathways are associated with responses to radiotherapy in NPC patients. We selected 3 SNPs in cell cycle pathway and 5 SNPs in NF-κB pathway and genotyped them in 154 NPC patients treated with radiotherapy. Multivariate logistic regression was used to determine the association of these 8 SNPs with the responses to radiotherapy. We observed that cyclin-dependent kinase inhibitor gene CDKN2A rs3088440 was significantly related with a poorer treatment efficacy on the primary tumor and cervical lymph node after radiotherapy, and also with a decreased risk of grade 3–4 acute radiation-induced myelosuppression. In some subgroups, cyclin D1 gene CCND1 rs9344 and inhibitor of κB kinase gene IKBKB rs12676482 were related with the grade 3–4 acute radiation-induced myelosuppression, and CCND1 rs9344 was also associated with grade 3–4 acute radiation-induced oral mucositis. The current results reveal that SNPs in genes of cell cycle pathwayand NF-κB pathway have the potential to predict the clinical responses to radiotherapy for NPC patients.

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The CCND1 G870A Gene Polymorphism and Brain Tumor Risk: a Meta-analysis

Cited by 13 publications

References 31 publications

Brief Descriptive Epidemiology of Primary Malignant Brain Tumors from North-East India

Brief Descriptive Epidemiology of Primary Malignant Brain Tumors from North-East India

Association of Cyclin D1 Variants with Head and Neck Cancer Susceptibility: Evidence from a Meta-analysis

The impacts of single nucleotide polymorphisms in genes of cell cycle and NF-κB pathways on the efficacy and acute toxicities of radiotherapy in patients with nasopharyngeal carcinoma

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