2013
DOI: 10.1182/blood-2012-09-435057
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The CD300 molecules: an emerging family of regulators of the immune system

Abstract: The CD300 family of molecules modulates a broad and diverse array of immune cell processes via their paired activating and inhibitory receptor functions. The description that CD300 molecules are able to recognize lipids, such as extracellular ceramide, phosphatidylserine, and phosphatidylethanolamine, that are exposed on the outer leaflet of the plasma membrane of dead and activated cells has opened a new field of research. Through their binding to lipids and other ligands, this family of receptors is poised t… Show more

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Cited by 196 publications
(284 citation statements)
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“…Q6SJQ7) is a member of the CD300 family, which modulates a broad and diverse array of immune-cell processes via paired activating and inhibitory receptors (17). CD300lf is an inhibitory receptor, and their paired activating receptor is CD300ld.…”
Section: Resultsmentioning
confidence: 99%
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“…Q6SJQ7) is a member of the CD300 family, which modulates a broad and diverse array of immune-cell processes via paired activating and inhibitory receptors (17). CD300lf is an inhibitory receptor, and their paired activating receptor is CD300ld.…”
Section: Resultsmentioning
confidence: 99%
“…CD300lf and CD300ld work together as paired receptors, probably recognizing the same ligand as they work in opposite ways to maintain cellular homeostasis (17). The expression of CD300lf and CD300ld is restricted to granulocytes, bone-marrow mast cells, and dendritic cells.…”
Section: Discussionmentioning
confidence: 99%
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“…30 The human CD300 receptors are type I transmembrane proteins with single IgV-like extracellular domains that are mainly expressed by myeloid cells. [31][32][33] The orthologous mouse family has a variety of names, including CMRF-like molecules (CLM), 31,32,34 but for simplicity in this report we use the human nomenclature for both species. Mouse CD300f (CLM-1) possesses both activating and inhibitory signaling potentials for regulation of AC engulfment upon PS recognition.…”
mentioning
confidence: 99%
“…20 CD300b has a short intracellular tail and gains activation potential by association with DNAX activating protein of 12 kDa (DAP12) or DAP10 adaptor molecules. 21 CD300b is predominantly expressed on myeloid cells, including neutrophils, macrophages and mast cells.…”
mentioning
confidence: 99%