The cell cycle in the small intestine transplanted beneath the kidney capsule in syngenic mice

Rowiński, J; Kucharczyk, Kazimierz; Boniecka, Teresa

doi:10.1007/bf00221125

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…However, Huggins and those after focused their attention on heterologous bone formation along the wall of the cyst, and did not address the details of epithelialization 11–13 . On the other hand, other hollow organs were also observed to form cysts and epithelialize 14–18 . To date, a comprehensive study of these observations has not been carried out, and their potential usefulness for regenerative medicine has not been appreciated.…”

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confidence: 99%

Transplantation of the urinary bladder and other organs in the subcutaneous tissue induces cyst formation and epithelialization: its potential usefulness in regenerative medicine

Sawada

Esaki

Sheng

et al. 2004

Wound Repair Regeneration

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Certain hollow organs are known to form cysts when heterologously transplanted. In order to examine the usefulness of the phenomenon for regenerative medicine, rat urinary bladders and other organs were allo-transplanted under the subcutaneous tissue of the back. These transplanted tissues very often formed cysts covered with epithelia. The epithelia covered an area about twice the original size. In the case of the urinary bladder, the epithelium started moving from the edge of the transplants around day 3 after the operation, and as time proceeded, the tela submucosa and tunica muscularis also moved to encircle the epithelium, and formed the wall of the cyst. The basal laminae were formed under the newly expanded epithelium slightly behind the leading tip. All of the organs tested had the capability of cyst formation and epithelialization, although their rate differed between organs. The results are discussed with reference to the potential use of cyst formation for regenerating damaged organs.

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mentioning

confidence: 99%

Transplantation of the urinary bladder and other organs in the subcutaneous tissue induces cyst formation and epithelialization: its potential usefulness in regenerative medicine

Sawada

Esaki

Sheng

et al. 2004

Wound Repair Regeneration

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The Role of the Pineal Gland in Neural Control of Cell Proliferation in Healthy and Malignant Tissue

Callaghan¹

2001

The Pineal Gland and Cancer

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Cell kinetics of the marine spongeHalisarca caeruleareveal rapid cell turnover and shedding

Goeij

Kluijver

Duyl

et al. 2009

Journal of Experimental Biology

115

174

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SUMMARYThis study reveals the peculiar in vivo cell kinetics and cell turnover of the marine sponge Halisarca caerulea under steady-state conditions. The tropical coral reef sponge shows an extremely high proliferation activity, a short cell cycle duration and massive cell shedding. Cell turnover is predominantly confined to a single cell population, i.e. the choanocytes, and in this process apoptosis only plays a minor role. To our knowledge, such fast cell kinetics under steady-state conditions, with high turnover by shedding in the absence of apoptosis, has not been observed previously in any other multicellular organism. The duration of the cell cycle in vivo resembles that of unicellular organisms in culture. Morphological and histochemical studies demonstrate compartmentalization of choanocytes in the sponge tissue, which corresponds well with its remarkable cellular kinetics. Coral reef cavity sponges, like H. caerulea, inhabit low nutrient tropical waters, forcing these organisms to filter large volumes of water and to capture the few nutrients efficiently. Under these oligotrophic conditions, a high cell turnover may be considered as a very useful strategy, preventing permanent damage to the sponge by environmental stress. Halisarca caerulea maintains its body mass and keeps its food uptake system up to date by constantly renewing its filter system. We conclude that studies on cell kinetics and functional morphology provide new and essential information on the growth characteristics and the regulation of sponge growth in vivo as well as in vitro and the role of choanocytes in tissue homeostasis.

show abstract

The cell cycle in the small intestine transplanted beneath the kidney capsule in syngenic mice

Cited by 3 publications

References 6 publications

Transplantation of the urinary bladder and other organs in the subcutaneous tissue induces cyst formation and epithelialization: its potential usefulness in regenerative medicine

Transplantation of the urinary bladder and other organs in the subcutaneous tissue induces cyst formation and epithelialization: its potential usefulness in regenerative medicine

The Role of the Pineal Gland in Neural Control of Cell Proliferation in Healthy and Malignant Tissue

Cell kinetics of the marine spongeHalisarca caeruleareveal rapid cell turnover and shedding

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