The Celution^®System: Automated Processing of Adipose-Derived Regenerative Cells in a Functionally Closed System

Uncultured adipose-derived regenerative cells (ADRCs) seeded in collagen scaffold improves dermal regeneration, enhancing early vascularization and structural organization following thermal burns

“…favoring tissue repair and regeneration [8][9][10][11][12][13][14][15]31,32]. In this study, we found that seeding uncultured ADRCs onto CBM increased local vascularization of the wound bed tissue, both beneath and within the CBM itself.…”

“…The SVF is a heterogeneous cell population that contains endothelial cells, fibroblasts, smooth muscle cells, macrophages and adiposederived stem cells [8,9]. Clinical-grade SVF has been referred to as Adipose Derived Regenerative Cells (ADRCs) [10]. A number of preclinical studies have shown that ADRCs have the capacity to promote angiogenesis and to modulate inflammation.…”

Adipose-Derived Regenerative Cell Therapy for Burn Wound Healing: A Comparison of Two Delivery Methods

“…8,9 We have referred to clinical grade SVF as adipose-derived regenerative cells (ADRCs). 10,11 Studies in renal and cardiovascular injury models have described a beneficial role of ADRCs during repair that appears to be mediated, at least in part, by modulation of the inflammatory response and/or promoting tissue vascularization and matrix deposition. This activity arises from the ability of ADRCs to secrete proangiogenic factors and/or differentiate toward lineage-committed cells.…”

Advanced Technologies in Dermatology

“…Cytori Therapeutics, Inc. also proposes a device for autologous cell therapy using fractions of cells sourced from fatty tissue (ADRCs). Adipose tissue is a good source of stem cells, but the sine qua non condition for the use of The Celution ® System is the minimal amount of fatty tissue of 200 g. In our experience, the whole sourcing and transformation process takes about 2.5 h even though Fraser and associates cites 1.5 h [28], the equivalent of the transformation of the framework in our device. Our Center uses this system as liposuction is a noninvasive procedure while the amount of sourced stem cells and regenerative cells does not require a long cell culturing process.…”

“…A series of methods for the treatment of scars exist, yet neither one of them is fully effective. Since the use of one single method provokes a rapid relapse of the illness, a combined therapeutic approach is usually administered, allowing for a good cosmetic effect [28]. The combined therapeutic approach employing cryotherapy alone or combined with the use of steroids is one of the leading ways of scar treatment.…”