The central hypotensive effect induced by α2-adrenergic receptor stimulation is dependent on endothelial nitric oxide synthase

Feldman, Josiane; Fellmann, Lyne; Bousquet, Pascal

doi:10.1097/hjh.0b013e3282f7cbab

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…Therefore, all above results suggested that serum NO may play an important role in improving arterial oxygenation in ventilated lung. It is reported that Dex can induce vasodilation through activation NO synthase (NOS) [ 37 , 38 ]. In the current study, Dex significantly increased serum NO concentration, concomitant with decreased shunt fraction and increased PaO2, which indicates that Dex may have induced vasodilation in the ventilated lung by enhancing NO release.…”

Section: Discussionmentioning

confidence: 99%

Intravenous Infusion of Dexmedetomidine Combined Isoflurane Inhalation Reduces Oxidative Stress and Potentiates Hypoxia Pulmonary Vasoconstriction during One‐Lung Ventilation in Patients

Xia

Yin

et al. 2015

Mediators of Inflammation

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Inhalation anesthetic isoflurane inhibits hypoxia pulmonary vasoconstriction (HPV), while dexmedetomidine (Dex) could reduce the dose of isoflurane inhalation and potentiate HPV, but the mechanism is unclear. Inhibition of reactive oxygen species (ROS) production can favor HPV during one-lung ventilation (OLV). Similarly, nitric oxide (NO), an important endothelium-derived vasodilator in lung circulation, can decrease the regional pulmonary vascular resistance of ventilated lung and reduce intrapulmonary shunting. We hypothesized that Dex may augment HPV and improve oxygenation during OLV through inhibiting oxidative stress and increasing NO release. Patients undergoing OLV during elective thoracic surgery were randomly allocated to either isoflurane + saline (NISO, n = 24) or isoflurane + dexmedetomidine (DISO, n = 25) group. Anesthesia was maintained with intravenous remifentanil and inhalational isoflurane (1.0–2.0%), with concomitant infusion of dexmedetomidine 0.7 μgkg−1h−1 in DISO and saline 0.25 mL kg−1h−1 in NISO group. Hemodynamic variables or depth of anesthesia did not significantly differ between groups. Administration of Dex significantly reduced Qs/Qt and increased PaO2 after OLV, accompanied with reduced lipid peroxidation product malondialdehyde and higher levels of SOD activity as well as serum NO (all P < 0.05 DISO versus NISO). In conclusion, reducing oxidative stress and increasing NO release during OLV may represent a mechanism whereby Dex potentiates HPV.

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Section: Discussionmentioning

confidence: 99%

Intravenous Infusion of Dexmedetomidine Combined Isoflurane Inhalation Reduces Oxidative Stress and Potentiates Hypoxia Pulmonary Vasoconstriction during One‐Lung Ventilation in Patients

Xia

Yin

et al. 2015

Mediators of Inflammation

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“…In hypertensive o-3 fatty acid-deficient rats at 36 weeks, there was a significant down regulation of a 2A adrenergic receptor and b 1 adrenergic x-3 Fatty acid deficiency and hypertension DP Begg et al receptor genes compared with both sufficient groups. Importantly, the central pre-synaptic a 2A adrenergic receptor agonists are known to produce hypotension, 42 and a 2A adrenergic receptorÀ/À mice are hypertensive, 43 and unresponsive to the action of a 2 agonists. 44 Conversely, central administration of a b adrenergic receptor antagonist produces a potent hypotensive effect.…”

Section: Discussionmentioning

confidence: 99%

Hypothalamic gene expression in ω-3 PUFA-deficient male rats before, and following, development of hypertension

et al. 2011

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Dietary deficiency of ω-3 fatty acids (ω-3 DEF) produces hypertension in later life. This study examined the effect of ω-3 DEF on blood pressure and hypothalamic gene expression in young rats, before the development of hypertension, and in older rats following the onset of hypertension. Animals were fed experimental diets that were deficient in ω-3 fatty acids, sufficient in short-chain ω-3 fatty acids or sufficient in short- and long-chain ω-3 fatty acids, from the prenatal period until 10 or 36 weeks-of-age. There was no difference in blood pressure between groups at 10 weeks-of-age; however, at 36 weeks-of-age ω-3 DEF animals were hypertensive in relation to sufficient groups. At 10 weeks, expression of angiotensin-II(1A) receptors and dopamine D(3) receptors were significantly increased in the hypothalamic tissue of ω-3 DEF animals. In contrast, at 36 weeks, α(2a) and β(1) adrenergic receptor expression was significantly reduced in the ω-3 DEF group. Brain docosahexaenoic acid was significantly lower in ω-3 DEF group compared with sufficient groups. This study demonstrates that dietary ω-3 DEF causes changes both in the expression of key genes involved in central blood pressure regulation and in blood pressure. The data may indicate that hypertension resulting from ω-3 DEF is mediated by the central adrenergic system.

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“…According to Kirihara et al ( 42 ), following the administration of MMB, a reduction in blood pressure was observed until the 20 min mark, after which it stabilized during anesthesia. MMB, acting as an alpha2-adrenergic receptor agonist, is known to decrease blood pressure ( 43 ). However, Kirihara et al ( 42 ) noted a significant increase in systolic blood pressure at 10 min post-administration in the MMB group compared to the KX group.…”

Section: Discussionmentioning

confidence: 99%

Effect of experimental periodontitis on cardiac functions: a comprehensive study using echocardiography, hemodynamic analysis, and histopathological evaluation in a rat model

Elhaieg,

Farag,

Elfadadny

et al. 2023

Front. Vet. Sci.

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IntroductionPeriodontitis is a prevalent and severe dental condition characterized by the gradual degradation of the bone surrounding the teeth. Over the past two decades, numerous epidemiological investigations have suggested a potential link between periodontitis and cardiovascular disease. However, the complex mechanistic relationship between oral health issues and cardiovascular disorders remains unclear.AimThis study aimed to explore comprehensively the cardiac function through various methods, including conventional echocardiography, intraventricular pressure gradient (IVPG) analysis, speckle tracking echocardiography (STE), and hemodynamics analysis.MethodsLigature-induced periodontitis was established in a group of rats while the second group served as sham. The successful establishment of the periodontitis model was confirmed through staining and radiographic examination of the affected mandibles.ResultsX-ray films and methylene blue staining revealed alveolar bone resorption in the affected first molar in the model rats, confirming the successful induction of periodontitis. The rats with periodontitis displayed a decrease in ejection fraction compared to the sham group, accompanied by a decrease in mid-to-apical IVPG and mid IVPG. Lower values of strain rate were recorded in the apical segment of the septum, the middle segment of the septum, and the basal segment of the lateral free wall in the periodontitis group, which was associated with histopathological examination showing some degree of myocardial tissue damage. Conversely, rats with periodontitis showed an increase in heart rate, end-systolic volume, and arterial elastance when compared to the sham rats. However, they also exhibited a decrease in stroke work, stroke volume, cardiac output, and end-systolic pressure.ConclusionThis study suggests that experimental periodontitis may lead to cardiac dysfunction especially compromised systolic function and myocardial relaxation, potentially indicating an increased risk of cardiovascular events in clinical periodontitis cases. The comprehensive assessment of cardiac function, hemodynamics, and histopathological evaluation underscores the profound impact of periodontitis on heart functions within this specific experimental model.

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The central hypotensive effect induced by α2-adrenergic receptor stimulation is dependent on endothelial nitric oxide synthase

Cited by 4 publications

References 18 publications

Intravenous Infusion of Dexmedetomidine Combined Isoflurane Inhalation Reduces Oxidative Stress and Potentiates Hypoxia Pulmonary Vasoconstriction during One‐Lung Ventilation in Patients

Intravenous Infusion of Dexmedetomidine Combined Isoflurane Inhalation Reduces Oxidative Stress and Potentiates Hypoxia Pulmonary Vasoconstriction during One‐Lung Ventilation in Patients

Hypothalamic gene expression in ω-3 PUFA-deficient male rats before, and following, development of hypertension

Effect of experimental periodontitis on cardiac functions: a comprehensive study using echocardiography, hemodynamic analysis, and histopathological evaluation in a rat model

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