The Central Nervous System and Atherogenesis: Interrelationships

Effects of corticotropin-releasing hormone (CRH) on endothelin-1 and NO release, mediated by CRH receptor subtype R2: A potential link between stress and endothelial dysfunction?

“…References to a link of central networks with endothelial function were first made by Gutstein and Wu [14]. Electric stimulation of the hypothalamus resulted in coronary endothelial damage and denudation, proliferation of smooth muscle cells, and coronary vasospasm; the pathophysiological mechanisms remain unknown.…”