The changes of Lp-PLA2 in patients with gestational diabetes and its clinical significance

Wang, Guohua; Jun, Jin Hyun; Liu, Yaqiong; Fuyan, Yang; Shi, Dan; Zhang, Yi; Zhao, Yimei; Wang, Yang

doi:10.1097/md.0000000000026786

Cited by 6 publications

(5 citation statements)

References 27 publications

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“…This increased fatty acid β-oxidation produced a large amount of acetyl-CoA, thus leading to a significant increase in TC synthesis and a decrease in HDL-C synthesis. 25,26 These findings were consistent with what we have found regarding the changes in lipid profiles in patients with GDM (Table 1). We further investigated the relationship between ATG7 levels and TG levels, LDL-C levels, TC levels, and HDL-C levels in patients with GDM.…”

Section: Discussionsupporting

confidence: 91%

“…This decreased lipoprotein lipase activity reduced TG degradation and increased TG levels and LDL-C levels in the blood. 25 , 26 However, there was higher fatty acid β-oxidation activity in patients with GDM than in patients without GDM. This increased fatty acid β-oxidation produced a large amount of acetyl-CoA, thus leading to a significant increase in TC synthesis and a decrease in HDL-C synthesis.…”

Section: Discussionmentioning

confidence: 98%

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Lower ATG7 Levels are Associated with a Higher Risk of Gestational Diabetes Mellitus: A Cross-Sectional Study

Lu¹,

Ma²,

Deng³

et al. 2022

DMSO

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Objective This study aimed to investigate ATG7 levels in pregnant women with and without gestational diabetes mellitus (GDM) and explore the potential associations between ATG7 levels and GDM. Methods This was a cross-sectional study conducted in a large tertiary hospital in Chengdu, China. The ATG7 levels in pregnant women at between 24 and 28 weeks of gestation with (n=84) and without GDM (n=649) were measured by using an ELISA kit. Glucose, HbA1c, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were measured by an automatic biochemistry analyser. The homeostasis model assessment of insulin resistance (HOMA-IR) and insulin secretion (HOMA-β) were calculated according to published formulas. The associations of ATG7 levels with laboratory parameters, GDM, and insulin resistance were evaluated using correlation analysis or a regression model. Results The ATG7 levels were significantly lower in pregnant women with GDM than in those without GDM. The correlation analyses found that ATG7 levels correlated positively with HOMA-β but correlated negatively with HOMA-IR, oral glucose tolerance test (OGTT) glucose levels, TGs, and LDL-C. There were no significant correlations between ATG7 levels and HbA1c, HDL-C, or TC. After adjusting for potential confounders, lower ATG7 levels were shown to be associated with a higher risk of GDM. Furthermore, multiple linear regression analyses showed that ATG7 levels were negatively associated with insulin resistance. Conclusion ATG7 levels are significantly lower in pregnant women with GDM than in those without GDM, and lower ATG7 levels are associated with a higher risk of GDM. ATG7 levels were negatively associated with insulin resistance. Autophagy deficiency, which is caused by lower ATG7 levels, may be the underlying mechanism that mediates insulin resistance in the development of GDM.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 98%

Lower ATG7 Levels are Associated with a Higher Risk of Gestational Diabetes Mellitus: A Cross-Sectional Study

Lu¹,

Ma²,

Deng³

et al. 2022

DMSO

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“…Previous studies suggested that copper is tightly associated with liver cirrhosis and development of HCC, and with the survival of HCC patients [19,25,46]. To investigate the role of copper metabolism in HCC, we searched GSEA website online with the keyword "copper" and identified 14 copper metabolismrelated pathways containing 134 unique genes (Supplementary Tables 2, 3).…”

Section: Distinct Features Of Hcc In Copper Metabolismrelated Pathwaysmentioning

confidence: 99%

“…Except for its aforementioned functions under physiological processes, copper also involves in the tumorigenesis and development of HCC. An early study indicated that copper contents correlated with liver cirrhosis and HCC, and serum Cu levels might be helpful in detecting HCC [25]. Besides, high level of serum copper was associated with shorter survival of HCC patients [19,26].…”

Section: Introductionmentioning

confidence: 99%

Copper metabolism-related risk score identifies hepatocellular carcinoma subtypes and SLC27A5 as a potential regulator of cuproptosis

Li,

Wang,

Guo

et al. 2023

Aging

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Aims: Dysregulated copper metabolism has been noticed in many types of cancer including hepatocellular carcinoma (HCC); however, a comprehensive understanding about this dysregulation still remains unclear in HCC. Methods: A set of bioinformatic tools was integrated to analyze the expression and prognostic significance of copper metabolism-related genes. A related risk score, termed as CMscore, was developed via univariate Cox regression, least absolute shrinkage and selection operator (LASSO) Cox regression and multivariate Cox regression. Pathway enrichment analyses and tumor immune cell infiltration were further investigated in CMscore stratified HCC patients. Weighted correlation network analysis (WGCNA) was used to identify potential regulator of cuproptosis. Results: Copper metabolism was dysregulated in HCC. HCC patients in the high-CMscore group showed a significantly lower overall survival (OS) and enriched in most cancer-related pathways. Besides, HCC patients with high CMscore had higher expression of pro-tumor immune infiltrates and immune checkpoints. Moreover, cancer patients with high CMscore from two large cohorts exhibited significantly prolonged survival time after immunotherapy. WGCNA and subsequently correlation analysis revealed that SLC27A5 might be a potential regulator of cuproptosis in HCC. In vitro experiments revealed that SLC27A5 inhibited cell proliferation and migration of HCC cells and could upregulate FDX1, the key regulator of cuproptosis. Significance: The CMscore is helpful in clustering HCC patients with distinct prognosis, gene mutation signatures, and sensitivity to immunotherapy. SLC27A5 might serve as a potential target in the induction of cuproptosis in HCC.

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“…It has been shown that higher serum copper levels are associated with poorer survival in liver cancer [10]. According to previous research, liver copper content is closely associated Ivyspring International Publisher with hepatocellular carcinoma [11], The metabolism of copper affects the microenvironment of tumors as well. Hepatocellular carcinoma (HCC) still lacks a clear understanding of the mechanisms that cause cuproptosis.…”

Section: Introductionmentioning

confidence: 98%

Development and Validation of the novel Cuproptosis- and Immune-related Signature for Predicting Prognosis in Hepatocellular Carcinoma

Zhang,

Sui,

Zhong

et al. 2024

J. Cancer

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Background : Hepatocellular carcinoma often results in late-stage diagnosis, leading to decreased treatment success. To improve prognosis, this study integrates cuproptosis with immune risk scoring models for HCC patients. Method: We identified differentially expressed genes connected to cuproptosis and immune responses using Pearson correlation. A risk signature was then constructed via LASSO regression, and its robustness was validated in the International Cancer Genome Consortium dataset. Additionally, qPCR confirmed findings in tumor and normal tissues. Results : Eight genes emerged as key prognostic markers from the 110 differentially expressed genes linked to cuproptosis and immunity. A risk-scoring model was developed using gene expression, effectively categorizing patients into low- or high-risk groups. Validated in the ICGC dataset, high-risk patients had significantly reduced survival times. Multivariate Cox regression affirmed the risk signature's independent predictive capability. A clinical nomogram based on the risk signature was generated. Notably, low-risk patients might benefit more from immune checkpoint inhibitors. qPCR and western blotting results substantiated our bioinformatics findings. Conclusions : The genetic risk signature linked to cuproptosis and immunity holds potential as a vital prognostic biomarker for Hepatocellular carcinoma, providing avenues for tailored therapeutic strategies.

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The changes of Lp-PLA2 in patients with gestational diabetes and its clinical significance

Cited by 6 publications

References 27 publications

Lower ATG7 Levels are Associated with a Higher Risk of Gestational Diabetes Mellitus: A Cross-Sectional Study

Lower ATG7 Levels are Associated with a Higher Risk of Gestational Diabetes Mellitus: A Cross-Sectional Study

Copper metabolism-related risk score identifies hepatocellular carcinoma subtypes and SLC27A5 as a potential regulator of cuproptosis

Development and Validation of the novel Cuproptosis- and Immune-related Signature for Predicting Prognosis in Hepatocellular Carcinoma

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