The Changing Microbial Epidemiology in Cystic Fibrosis

Abstract

SUMMARY Infection of the airways remains the primary cause of morbidity and mortality in persons with cystic fibrosis (CF). This review describes salient features of the epidemiologies of microbial species that are involved in respiratory tract infection in CF. The apparently expanding spectrum of species causing infection in CF and recent changes in the incidences and prevalences of infection due to specific bacterial, fungal, and viral species are described. The challenges inherent in tracking and interpreting rates of infection in this patient population are discussed.

Changing Epidemiology of the Respiratory Bacteriology of Patients With Cystic Fibrosis

“…Others have also reported changing trends in CF microbiology. The most common Burkholderia species has changed from B cenocepacia to B multivorans in both the United States 5 and the United Kingdom. 6 Increases in MRSA, [7][8][9] A xylosoxidans, 8,10,11 and S maltophilia 8,9,12 have also been reported.…”

Le microbiome pulmonaire en 2015

“…Cette colonisation et l'infection broncho-pulmonaire qui en résulte restent le problème majeur pour la surveillance et le traitement de cette maladie géné-tique touchant tous les continents [21]. L'infection est généralement chronique.…”

“…L'infection est généralement chronique. Les exacerbations pulmonaires aiguës intercurrentes détériorent progressivement la fonction respiratoire conditionnant en grande partie le pronostic vital des patients [21]. Aujourd'hui encore, le suivi de ces colonisations/infections est réa-lisé essentiellement par les méthodes conventionnelles (examen direct et cultures microbiologiques).…”

RND-4 efflux transporter gene deletion in Burkholderia cenocepacia J2315: a proteomic analysis

“…It has also been reported as a cause of bacteraemia [2]. Up to 8% of patients are colonized by Bcc for months or even years.…”