The Master Minimum Equipment List (MMEL) is an important technical manual for civil aircraft to meet release conditions and achieve release with failures, and it is also a key reference manual for airlines to develop the minimum equipment list. This paper firstly elaborates the relationship between PMMEL, MMEL and MEL, initially studies the system safety assessment process, and focuses on the logical relationship between system safety and PMMEL project development by detailing the role of system safety assessment FHA, FMEA and FTA in the development and analysis process of PMMEL during the aircraft development phase, to ensure the PMMEL work and The logical relationship between system safety and PMMEL project development is discussed to ensure the close integration between PMMEL work and civil aircraft development, to provide theoretical basis for manufacturers to fully consider the design of PMMEL in the development phase, and then to improve the capability of the developed aircraft with failure release.