The characterization and prognostic significance of right ventricular glucose metabolism in non-ischemic dilated cardiomyopathy

Abstract

Increased RV FDG uptake was associated with RV dysfunction and may be a prognostic predictor of all-cause mortality or heart transplantation in patients with DCM.

Positron emission tomography: An additional prognostic tool in dilated cardiomyopathy?

“…21 demonstrates that increased RV glucose metabolism is a common feature in patients with idiopathic DCM and confirms the relationship of RV 18 F-FDG uptake with the severity of RV dysfunction already documented in HF. Importantly, this study extends previous results by demonstrating the adverse prognostic role of relative increase of glucose metabolism in the RV as compared with the LV underlying the importance of biventricular functional and metabolic changes in these patients.…”

Dioxygen and Metabolism; Dangerous Liaisons in Cardiac Function and Disease

“…Additional data demonstrated that the metabolic switch is still preserved 6–8 weeks after TAC in mice (Kolwicz et al, 2012 ; Pereira et al, 2013 , 2014 ), and this has been also validated in other animal models of pressure overload or volume overload or HF in rats, rabbits and dogs (Taegtmeyer and Overturf, 1988 ; Allard et al, 1994 ; Christe and Rodgers, 1994 ; Christian et al, 1998 ; Labinskyy et al, 2007 ). Another study, this time in patients suffering from non-ischemic DCM, right ventricle glucose uptake had been monitored by PET imaging (using the radioactive isotope [ 18 F] fluodeoxyglucose) (Wang L. et al, 2016 ). Conclusions of these experiments demonstrated a correlation between increased right ventricle glucose uptake and dysfunction (Wang L. et al, 2016 ).…”

“…Another study, this time in patients suffering from non-ischemic DCM, right ventricle glucose uptake had been monitored by PET imaging (using the radioactive isotope [ 18 F] fluodeoxyglucose) (Wang L. et al, 2016 ). Conclusions of these experiments demonstrated a correlation between increased right ventricle glucose uptake and dysfunction (Wang L. et al, 2016 ). In addition, a recent paper established the metabolomics profile of non-ischemic HF in patients (Mueller-Hennessen et al, 2017 ).…”

Perspective and future direction of intraventricular mechanical dyssynchrony assessment

“…24 Increased RV FDG uptake is associated with RV dysfunction (Figure 3) and may be a prognostic predictor of all-cause mortality or heart transplantation in patients with dilated cardiomyopathy. 25 There is a significant correlation between RVEF and RV FDG uptake; in patients with a cRVSUV (correct RV standard uptake value) [ 7.01, heart transplantation is more frequent. Furthermore, there is a good correlation between RV dysfunction, RV FDG uptake, and severe pulmonary hypertension (mean pulmonary artery pressure C 40 c Figure 1.…”

“…mmHg, or an RV systolic pressure C 50 mmHg); and severe pulmonary hypertension has a poor prognosis. 24,25 Thus, RV performance in patients of pulmonary hypertension requires optimal assessment; and RV dyssynchrony measured by phase analysis of FDG-PET is significantly related to RV dysfunction. 26 Figure 2.…”