The CHCHD2-CHCHD10 protein complex is modulated by mitochondrial dysfunction and alters lipid homeostasis in the mouse brain
Jule Gerlach,
Paola Pireddu,
Xiaoqun Zhang
et al.
Abstract:The highly conserved CHCHD2 and CHCHD10 are small mitochondrial proteins residing in the intermembrane space. Recently, mutations in theCHCHD2andCHCHD10genes have been linked to severe disorders, including Parkinson’s disease and amyotrophic lateral sclerosis. In cultured cells, a small fraction of CHCHD2 and CHCHD10 oligomerize to form a high molecular weight complex of unknown function. Here, we generated a whole-bodyChchd2knockout mouse to investigate thein vivorole of CHCHD2 and its protein complex. We sho… Show more
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