The chemical constituents from red alga Gymnogongrus flabelliformis Harv.

Yuan, Zhihang; Han, Lijun; Su, Hua; Shi, Dongxia; Sun, Jie; Li, Shuai; Jiangong, Shi

doi:10.1007/s00343-008-0190-5

Cited by 9 publications

(6 citation statements)

References 3 publications

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“…97°(CHCl 3 , c = 1.0), lit (Nagasawa et al 1969;Yuan et al 2008 Table 1. The NMR data were in agreement with cholest-4-en-3-one which was reported in the literature (Nagasawa et al 1969;Chiang et al 2007).…”

Section: Biotransformation Products Of Cholesterol By G Neofelifaecismentioning

confidence: 98%

Efficient biotransformation of cholesterol to androsta-1,4-diene-3,17-dione by a newly isolated actinomycete Gordonia neofelifaecis

Liu

Chen

et al. 2010

World J Microbiol Biotechnol

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A newly isolated actinomycete, Gordonia neofelifaecis (NRRL B-59395) from the faeces of Neofelis nebulosa, was used to selectively degrade the side-chain of cholesterol. The intermediates were purified and characterized. Quantitative analysis of the accumulated metabolites from cholesterol side-chain cleavage was conducted during the biotransformation. The results showed that the profile of accumulated intermediates was different from those of other reported microorganisms. Among the five metabolites, androsta-1,4-diene-3,17-dione (ADD) was the main product of the side-chain degradation, with a high conversion rate (87.2%), indicating its potential for industrial production of ADD. At the end of transformation, the substrate cholesterol was completely consumed. The effect of some factors on the bioconversion was also investigated. To our best knowledge, this is the first report regarding cholesterol side-chain cleavage using bacteria belonging to Gordonia.

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Section: Biotransformation Products Of Cholesterol By G Neofelifaecismentioning

confidence: 98%

Efficient biotransformation of cholesterol to androsta-1,4-diene-3,17-dione by a newly isolated actinomycete Gordonia neofelifaecis

Liu

Chen

et al. 2010

World J Microbiol Biotechnol

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“…As known, phenol and bromophenols are biologically active compounds [1][2][3][4][5][6][7][8][9][10][11][12][13]20,21]. Besides their biological importance, bromophenols are also useful for chemical purposes for instance they are used as precursors in synthetic organic chemistry [30].…”

Section: Synthesismentioning

confidence: 99%

“…The antioxidant properties of bromophenols 1, 13-17, and 19 were investigated using different antioxidant assays. The Fe 3+ -Fe 2+ reducing power of bromophenols 1, 13-17, and 19 was measured by the direct reduction of Fe 3+ (CN − ) 6 to Fe 2+ (CN − ) 6 , and was determined by measuring absorbance that resulted from the formation of the Perl's Prussian blue complex following the addition of excess ferric ions (Fe 3+ ). This method is based on the reduction of (Fe 3+ ) ferricyanide in stoichiometric excess relative to the antioxidants [32].…”

Section: Antioxidant Propertiesmentioning

confidence: 99%

“…2,2' ,3,3'-Tetrabromo-4,4' ,5,5'-tetrahydroxydiphenylmethane (1) and 3-bromo-4-(2,3-dibromo-4,5-dihydroxybenzyl)-5-methoxymethylpyrocatechol (2) were first isolated in 1977 [3]. Since then they have been obtained from different sources many times [4][5][6][7][8][9][10]. Compounds 1 and 2 exhibit important biological activities such as enzyme inhibition, cytotoxicity, feeding deterrent, and anti-microbial activities [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Since then they have been obtained from different sources many times [4][5][6][7][8][9][10]. Compounds 1 and 2 exhibit important biological activities such as enzyme inhibition, cytotoxicity, feeding deterrent, and anti-microbial activities [4][5][6][7][8][9]. It was reported that bromophenol 1 extracted from red algae is an inhibitor of protein tyrosine phosphatase, and it can be used to treat and prevent diabetes mellitus and obesity [11][12][13] (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and antioxidant properties of diphenylmethane derivative bromophenols including a natural product

Balaydın

Gülçın

Menzek

et al. 2010

Journal of Enzyme Inhibition and Medicinal Chemistry

122

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Bromination of bis(3,4-dimethoxyphenyl)methanone (5) gave four products (6-9) with mono, di, tri, and tetra Br under different conditions. Reduction and demethylation reactions of product 9 with tetra Br were performed, consecutively and a natural product, 5,5'-methylene bis(3,4-dibrombenzene-1,2-diol) (1), was obtained with a 53% yield. Five derivatives, (13-17) (bromophenols), of 1 were also synthesised. The antioxidant and radical scavenging activities of bromophenols 1 and 13-17 were determined by employing various in vitro assays such as 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH(*)), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid (ABTS(*+)), N,N-dimethyl-p-phenylenediamine dihydrochloride radical cation (DMPD(*+)), and superoxide anion radical (O(2)(*-)) scavenging, reducing ability determination by the Fe(3+)-Fe(2+) and Cu(2+)-Cu(+) cupric reducing antioxidant capacity (CUPRAC) transformation methods, hydrogen peroxide scavenging, and ferrous ion (Fe(2+)) chelating activities. Moreover, these activities were compared to those of synthetic standard antioxidant compounds such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol, and trolox. The results showed that the synthesised bromophenols had effective antioxidant power.

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Chemical constituents from the antitumor fraction of Trachyrhamphus serratus

Wang

Nie

et al. 2011

Chem Nat Compd

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The chemical constituents from red alga Gymnogongrus flabelliformis Harv.

Cited by 9 publications

References 3 publications

Efficient biotransformation of cholesterol to androsta-1,4-diene-3,17-dione by a newly isolated actinomycete Gordonia neofelifaecis

Efficient biotransformation of cholesterol to androsta-1,4-diene-3,17-dione by a newly isolated actinomycete Gordonia neofelifaecis

Synthesis and antioxidant properties of diphenylmethane derivative bromophenols including a natural product

Chemical constituents from the antitumor fraction of Trachyrhamphus serratus

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