The Chinese Herb Codonopsis pilosula Isolate Isorhapontigenin protects against oxidative stress injury by inhibiting the activation of PI3K/Akt signaling pathway

Abstract

We investigated the effects of the Chinese herb Codonopsis pilosula isolate isorhapontigenin on antioxidant factor and the PI3K/Serine/Akt signaling pathway in Parkinson's disease. This research was, therefore, carried out to explore a possible protective mechanism of isorhamnetin in Parkinson's disease. The results support that isorhapontigenin could effectively inhibit isorhapontigenin restored myeloperoxidase + induced reduction of antioxidant levels. Also, 1-Methyl-4-phenylpyridine up-regulated the expression of phosphorylated-Akt, phosphorylated-PI3K, and phosphorylated mammalian target of rapamycin, while isorhapontigenin inhibited the expression of phosphorylated-Akt, phosphorylated-PI3K, and phosphorylated-mammalian target of rapamycin. Furthermore, LY294002 improved the antioxidant effect of isorhapontigenin in PC12 cells, and insulin-like growth factor 1 inhibited the antioxidant effect of isorhapontigenin in PC12 cells. Our results support the finding that isorhamnetin enhanced the antioxidant effect induced by 1-Methyl-4-phenylpyridine in PC12 cells by suppressing the activation of the PI3K/Akt signaling pathway.

A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

“…Finally, CP can improve cognitive function, delay nerve aging, and protect nerve cells. It prevents and treats neurological diseases such as Alzheimer’s disease (AD) ( Zhi et al, 2023 ; Xie et al, 2024 ) and Parkinson’s ( Gu et al, 2020 ). CP and its active ingredients may improve the brain environment through antioxidant, anti-inflammatory, anti-neural cell apoptosis, etc., and promote the survival and functional recovery of nerve cells ( Hu et al, 2021 ; Chen H. et al, 2024 ; Xie et al, 2024 ), thus protecting the nervous system’s health and slowing down the development of neurological diseases.…”