The Chinese medicine babaodan suppresses LPS-induced sepsis by inhibiting NLRP3-mediated inflammasome activation

Li, Yufei; Sheng, Hongda; Qian, Jing; Wáng, Yì

doi:10.1016/j.jep.2022.115205

Cited by 17 publications

(6 citation statements)

References 35 publications

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“…After LPS induction, the expressions of major proinflammatory and apoptosis factors were significantly increased, and MGV significantly reduced the release of proinflammatory factors. Multiple studies have shown that bioactive compounds or their metabolites in various herbs can inhibit the progression of LPS ( Fu et al, 2021 ; Li et al, 2022b ). In the LPS-stimulated RAW264.7 cell inflammation model, MGV effectively improved LPS-induced inflammatory responses by inhibiting the production of prostaglandin E2 and the expression of cyclooxygenase-2 ( Li et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Mogroside V ameliorates broiler pulmonary inflammation via modulating lung microbiota and rectifying Th17/Treg dysregulation in lipopolysaccharides-induced lung injury

Li,

Shen,

Wang

et al. 2023

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Mogroside V ameliorates broiler pulmonary inflammation via modulating lung microbiota and rectifying Th17/Treg dysregulation in lipopolysaccharides-induced lung injury

Li,

Shen,

Wang

et al. 2023

Poultry Science

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“…Related to this, the probiotic Lactobacillus rhamnosus reduced sepsis mortality by rebalancing metabolic bile acid profiles [94]. Babaodan, a natural preparation, appeared to alter NF-κB and NLRP3 (NLR family pyrin domain containing 3) inflammasome complex assembly to limit LPS-induced sepsis [95]. The beneficial actions of Babaodan were believed to be due, in part, to bile acids.…”

Section: Gut Origin Of Sepsismentioning

confidence: 99%

Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases

Shi

Jin

Huang

2023

Cells

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The intestinal barrier is a precisely regulated semi-permeable physiological structure that absorbs nutrients and protects the internal environment from infiltration of pathological molecules and microorganisms. Bile acids are small molecules synthesized from cholesterol in the liver, secreted into the duodenum, and transformed to secondary or tertiary bile acids by the gut microbiota. Bile acids interact with bile acid receptors (BARs) or gut microbiota, which plays a key role in maintaining the homeostasis of the intestinal barrier. In this review, we summarize and discuss the recent studies on bile acid disorder associated with intestinal barrier dysfunction and related diseases. We focus on the roles of bile acids, BARs, and gut microbiota in triggering intestinal barrier dysfunction. Insights for the future prevention and treatment of intestinal barrier dysfunction and related diseases are provided.

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“…Bile acids and other regulatory molecules have been shown to induce the activation of the NLRP3 inflammasome ( 153 ). This causes the secretion of IL-1β, thus leading to transinflammatory liver injury and playing a role in reactive cholangiocyte inflammation in patients with PSC ( 154 ).…”

Section: Inflammasomes and Pyroptosis In Aildsmentioning

confidence: 99%

Inflammasome and pyroptosis in autoimmune liver diseases

et al. 2023

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Autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and IgG4-related sclerosing cholangitis (IgG4-SC) are the four main forms of autoimmune liver diseases (AILDs), which are all defined by an aberrant immune system attack on the liver. Most previous studies have shown that apoptosis and necrosis are the two major modes of hepatocyte death in AILDs. Recent studies have reported that inflammasome-mediated pyroptosis is critical for the inflammatory response and severity of liver injury in AILDs. This review summarizes our present understanding of inflammasome activation and function, as well as the connections among inflammasomes, pyroptosis, and AILDs, thus highlighting the shared features across the four disease models and gaps in our knowledge. In addition, we summarize the correlation among NLRP3 inflammasome activation in the liver-gut axis, liver injury, and intestinal barrier disruption in PBC and PSC. We summarize the differences in microbial and metabolic characteristics between PSC and IgG4-SC, and highlight the uniqueness of IgG4-SC. We explore the different roles of NLRP3 in acute and chronic cholestatic liver injury, as well as the complex and controversial crosstalk between various types of cell death in AILDs. We also discuss the most up-to-date developments in inflammasome- and pyroptosis-targeted medicines for autoimmune liver disorders.

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The Chinese medicine babaodan suppresses LPS-induced sepsis by inhibiting NLRP3-mediated inflammasome activation

Cited by 17 publications

References 35 publications

Mogroside V ameliorates broiler pulmonary inflammation via modulating lung microbiota and rectifying Th17/Treg dysregulation in lipopolysaccharides-induced lung injury

Mogroside V ameliorates broiler pulmonary inflammation via modulating lung microbiota and rectifying Th17/Treg dysregulation in lipopolysaccharides-induced lung injury

Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases

Inflammasome and pyroptosis in autoimmune liver diseases

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